{"id":"https://openalex.org/W77262767","doi":null,"title":"A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms.","display_name":"A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms.","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W77262767","mag":"77262767","pmid":"https://pubmed.ncbi.nlm.nih.gov/9251681"},"language":"en","primary_location":{"id":"pmid:9251681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9251681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064790156","display_name":"Nico van Belzen","orcid":"https://orcid.org/0000-0002-6540-0676","observed_orcids":["https://orcid.org/0000-0002-6540-0676"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N van Belzen","raw_affiliation_strings":["Department of Pathology, Erasmus University Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Erasmus University Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005487497","display_name":"Winand N.M. Dinjens","orcid":"https://orcid.org/0000-0002-9298-8380","observed_orcids":["https://orcid.org/0000-0002-9298-8380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W N Dinjens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012819090","display_name":"M P Diesveld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M P Diesveld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041964946","display_name":"Nicole A. Groen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Groen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085447752","display_name":"A C van der Made","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C van der Made","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Nozawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nozawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Vlietstra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Vlietstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026981971","display_name":"Jan Trapman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Trapman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088115842","display_name":"Fred T. Bosman","orcid":"https://orcid.org/0000-0002-1652-6977","observed_orcids":["https://orcid.org/0000-0002-1652-6977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F T Bosman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.202,"has_fulltext":false,"cited_by_count":253,"citation_normalized_percentile":{"value":0.9593213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"77","issue":"1","first_page":"85","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.13490000367164612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drg1","display_name":"DRG1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/colorectal-neoplasms","display_name":"colorectal neoplasia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/colon-adenoma","display_name":"colonic adenoma","score":0.7429999709129333},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5289999842643738},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7049999833106995},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.5770000219345093},{"id":"https://openalex.org/keywords/placental-membranes","display_name":"placental membranes","score":0.5009999871253967},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4269999861717224},{"id":"https://openalex.org/keywords/cell-shedding","display_name":"cell shedding","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7483790516853333},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6086576581001282},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5634811520576477},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.48249006271362305},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4527159631252289},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4342220723628998},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41923969984054565},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3560464382171631},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3261677026748657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07969388365745544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07704567909240723}],"mesh":[{"descriptor_ui":"D000099259","descriptor_name":"N-myc Downstream-Regulated Gene 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:9251681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9251681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/3efa17d5-67d5-4d51-b3c6-5ba3899cad28","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/3efa17d5-67d5-4d51-b3c6-5ba3899cad28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Belzen, N, Dinjens, W, Diesveld, MPG, Groen, NA, van der Made, A, Nozawa, Y, Vlietstra, RJ, Trapman, J & Bosman, FT 1997, 'A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms', Laboratory Investigation, vol. 77, no. 1, pp. 85-92.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/3efa17d5-67d5-4d51-b3c6-5ba3899cad28","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/3efa17d5-67d5-4d51-b3c6-5ba3899cad28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Laboratory Investigation, 77(1), 85 - 92. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:77262767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9251681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1605281376","https://openalex.org/W2298627975","https://openalex.org/W2100037910","https://openalex.org/W2073694547","https://openalex.org/W2008971584","https://openalex.org/W2037004149","https://openalex.org/W2101904652","https://openalex.org/W2355247477","https://openalex.org/W2079068568","https://openalex.org/W2120850855"],"abstract_inverted_index":{"To":[0],"identify":[1],"new":[2],"molecular":[3,118],"markers":[4],"for":[5],"differentiation":[6,24,65],"of":[7,25,53,66,77,98,108,120,165,188,211],"normal":[8,142,176],"and":[9,57,73,132,137,153,185,209],"neoplastic":[10],"colon":[11,28,68,91,143,151,177,215],"epithelium,":[12],"we":[13,38],"have":[14],"studied":[15],"changes":[16],"in":[17,22,63,80,90,129,150,169,175,182],"gene":[18,45],"expression":[19,147],"during":[20,62,204],"the":[21,26,67,166,183,194,214],"vitro":[23,64],"HT29-D4":[27,72],"carcinoma":[29,69,84,92],"cell":[30,70],"line.":[31],"Using":[32],"a":[33,40,51,96,113,116,163],"modified":[34],"differential":[35],"display":[36],"procedure,":[37],"cloned":[39],"novel":[41],"cDNA,":[42],"designated":[43],"differentiation-related":[44],"1":[46],"(Drg1).":[47],"Drg1":[48,78,88,102,123,145,160,178,199],"mRNA":[49,124,146],"has":[50],"length":[52],"approximately":[54,60],"3":[55],"kb":[56],"is":[58,94,125,148,180,201],"induced":[59],"20-fold":[61],"lines":[71],"Caco-2.":[74],"The":[75,101],"absence":[76],"induction":[79],"growth-inhibited":[81],"A431":[82],"epidermoid":[83],"cells":[85,93,191,212],"indicates":[86],"that":[87,111,174,192,198],"up-regulation":[89],"not":[95],"result":[97],"decreased":[99,149],"proliferation.":[100],"cDNA":[103],"contains":[104],"an":[105],"open-reading":[106],"frame":[107],"1182":[109],"bp":[110],"encodes":[112],"protein":[114,161,179,200],"with":[115],"predicted":[117],"weight":[119],"43":[121],"kd.":[122],"expressed":[126,181,202],"most":[127],"prominently":[128],"placental":[130],"membranes":[131,187],"prostate,":[133],"kidney,":[134],"small":[135],"intestine,":[136],"ovary":[138],"tissues.":[139],"Compared":[140],"to":[141],"mucosa,":[144],"adenomas":[152],"adenocarcinomas.":[154],"An":[155],"antiserum":[156],"raised":[157],"against":[158],"recombinant":[159],"detected":[162],"band":[164],"expected":[167],"size":[168],"Western":[170],"blots.":[171],"Immunohistochemistry":[172],"showed":[173],"cytoplasm":[184],"basolateral":[186],"surface":[189],"epithelial":[190],"border":[193],"gut":[195],"lumen,":[196],"indicating":[197],"late":[203],"differentiation,":[205],"just":[206],"before":[207],"apoptosis":[208],"shedding":[210],"into":[213],"lumen.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
