{"id":"https://openalex.org/W772488069","doi":null,"title":"Combined tandem mass spectrometry and ion mobility spectrometry in proteome analyses","display_name":"Combined tandem mass spectrometry and ion mobility spectrometry in proteome analyses","publication_year":2013,"publication_date":"2013-01-29","ids":{"openalex":"https://openalex.org/W772488069","mag":"772488069"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb","pdf_url":"https://pure.manchester.ac.uk/ws/files/54530161/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.manchester.ac.uk/ws/files/54530161/FULL_TEXT.PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081499704","display_name":"Ross Chawner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ross Chawner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081499704"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.08219999819993973,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.8769999742507935},{"id":"https://openalex.org/keywords/ion-mobility-spectrometry","display_name":"ion mobility spectrometry","score":0.9869999885559082},{"id":"https://openalex.org/keywords/collision-cross-sections","display_name":"collision cross sections","score":0.6480000019073486},{"id":"https://openalex.org/keywords/qconcat","display_name":"QconCAT","score":0.6510000228881836},{"id":"https://openalex.org/keywords/peptide-fragmentation","display_name":"peptide fragmentation","score":0.6179999709129333},{"id":"https://openalex.org/keywords/collision-induced-dissociation","display_name":"collision-induced dissociation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/electron-transfer-dissociation","display_name":"electron transfer dissociation","score":1.0},{"id":"https://openalex.org/keywords/basic-residues","display_name":"basic residues","score":0.5059999823570251},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.7850000262260437},{"id":"https://openalex.org/keywords/carboxypeptidase-b","display_name":"carboxypeptidase B","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C15213710","wikidata":"https://www.wikidata.org/wiki/Q904207","display_name":"Ion-mobility spectrometry","level":3,"score":0.7426053285598755},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.7394214868545532},{"id":"https://openalex.org/C112979427","wikidata":"https://www.wikidata.org/wiki/Q4949102","display_name":"Bottom-up proteomics","level":5,"score":0.7345170974731445},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7286427021026611},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6545124650001526},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6527841091156006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6219044923782349},{"id":"https://openalex.org/C48000682","wikidata":"https://www.wikidata.org/wiki/Q5227411","display_name":"Database search engine","level":3,"score":0.511235237121582},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.49744895100593567},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4938236176967621},{"id":"https://openalex.org/C86153913","wikidata":"https://www.wikidata.org/wiki/Q7682439","display_name":"Tandem mass tag","level":5,"score":0.43494218587875366},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4274289309978485},{"id":"https://openalex.org/C176107965","wikidata":"https://www.wikidata.org/wiki/Q3710336","display_name":"Collision-induced dissociation","level":4,"score":0.41251951456069946},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4039642810821533},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.394923597574234},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3430691659450531},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.27214545011520386},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20259538292884827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1759483814239502},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16069120168685913},{"id":"https://openalex.org/C97854310","wikidata":"https://www.wikidata.org/wiki/Q19541","display_name":"Search engine","level":2,"score":0.13186892867088318},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11690601706504822},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb","pdf_url":"https://pure.manchester.ac.uk/ws/files/54530161/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},{"id":"mag:772488069","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568642","pdf_url":null,"source":{"id":"https://openalex.org/S4306532718","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2013.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2013.","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb","pdf_url":"https://pure.manchester.ac.uk/ws/files/54530161/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W772488069.pdf","grobid_xml":"https://content.openalex.org/works/W772488069.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W35024136","https://openalex.org/W168524622","https://openalex.org/W1495020298","https://openalex.org/W1495926848","https://openalex.org/W1597678601","https://openalex.org/W1964443249","https://openalex.org/W1964895401","https://openalex.org/W1965942536","https://openalex.org/W1966669593","https://openalex.org/W1967287387","https://openalex.org/W1968518360","https://openalex.org/W1969145861","https://openalex.org/W1973753936","https://openalex.org/W1974732006","https://openalex.org/W1974830441","https://openalex.org/W1976591857","https://openalex.org/W1976727092","https://openalex.org/W1980427396","https://openalex.org/W1981080164","https://openalex.org/W1981593008","https://openalex.org/W1982405030","https://openalex.org/W1983335448","https://openalex.org/W1985564713","https://openalex.org/W1985625499","https://openalex.org/W1987918527","https://openalex.org/W1988006519","https://openalex.org/W1988308498","https://openalex.org/W1988614375","https://openalex.org/W1989948422","https://openalex.org/W1991207270","https://openalex.org/W1991437941","https://openalex.org/W1991849760","https://openalex.org/W1992252019","https://openalex.org/W1992275220","https://openalex.org/W1992623021","https://openalex.org/W1995969527","https://openalex.org/W1997237821","https://openalex.org/W1998261260","https://openalex.org/W1998570784","https://openalex.org/W1998692354","https://openalex.org/W2000819512","https://openalex.org/W2003760263","https://openalex.org/W2005716310","https://openalex.org/W2005876244","https://openalex.org/W2007425565","https://openalex.org/W2007845174","https://openalex.org/W2008336716","https://openalex.org/W2010164543","https://openalex.org/W2011137687","https://openalex.org/W2011419273","https://openalex.org/W2015529752","https://openalex.org/W2015788623","https://openalex.org/W2016717705","https://openalex.org/W2018247248","https://openalex.org/W2018307494","https://openalex.org/W2018408953","https://openalex.org/W2019050932","https://openalex.org/W2019812098","https://openalex.org/W2021501656","https://openalex.org/W2022936574","https://openalex.org/W2023096047","https://openalex.org/W2023591265","https://openalex.org/W2026465178","https://openalex.org/W2028445484","https://openalex.org/W2029911396","https://openalex.org/W2031214076","https://openalex.org/W2032194486","https://openalex.org/W2033171034","https://openalex.org/W2035123840","https://openalex.org/W2035459843","https://openalex.org/W2036884292","https://openalex.org/W2037542223","https://openalex.org/W2038554914","https://openalex.org/W2040720717","https://openalex.org/W2041575674","https://openalex.org/W2043732703","https://openalex.org/W2044620987","https://openalex.org/W2045445695","https://openalex.org/W2046308310","https://openalex.org/W2048091951","https://openalex.org/W2048858560","https://openalex.org/W2049166926","https://openalex.org/W2053424081","https://openalex.org/W2053827324","https://openalex.org/W2055934103","https://openalex.org/W2056971323","https://openalex.org/W2057009243","https://openalex.org/W2058526216","https://openalex.org/W2060291571","https://openalex.org/W2062193128","https://openalex.org/W2062429736","https://openalex.org/W2063987819","https://openalex.org/W2073292063","https://openalex.org/W2073401456","https://openalex.org/W2074717965","https://openalex.org/W2076415544","https://openalex.org/W2076818790","https://openalex.org/W2078187264","https://openalex.org/W2079817279","https://openalex.org/W2080442075","https://openalex.org/W2081620687","https://openalex.org/W2083749381","https://openalex.org/W2084428514","https://openalex.org/W2088550407","https://openalex.org/W2090035646","https://openalex.org/W2091375086","https://openalex.org/W2092837835","https://openalex.org/W2094171036","https://openalex.org/W2094898995","https://openalex.org/W2104372768","https://openalex.org/W2111638985","https://openalex.org/W2112947615","https://openalex.org/W2114018152","https://openalex.org/W2115588498","https://openalex.org/W2121612064","https://openalex.org/W2123716593","https://openalex.org/W2125123893","https://openalex.org/W2127456719","https://openalex.org/W2128053367","https://openalex.org/W2128635872","https://openalex.org/W2130706354","https://openalex.org/W2131741443","https://openalex.org/W2143694555","https://openalex.org/W2148352340","https://openalex.org/W2153028657","https://openalex.org/W2154912073","https://openalex.org/W2159308908","https://openalex.org/W2160446865","https://openalex.org/W2161574105","https://openalex.org/W2163153896","https://openalex.org/W2165839612","https://openalex.org/W2170846952","https://openalex.org/W2244786566","https://openalex.org/W2317233863","https://openalex.org/W2324861846","https://openalex.org/W2330891955","https://openalex.org/W2335117233","https://openalex.org/W2478139588"],"related_works":["https://openalex.org/W2133013796","https://openalex.org/W2107672801","https://openalex.org/W2014278111","https://openalex.org/W2404670384","https://openalex.org/W3134110697","https://openalex.org/W2986759583","https://openalex.org/W1965460732","https://openalex.org/W2285098170","https://openalex.org/W3179804029","https://openalex.org/W3195015580"],"abstract_inverted_index":{"Proteomic":[0],"studies":[1,35,318,389],"aim":[2],"to":[3,27,52,73,118,135,145,193,233,277,392,410,449,466],"identify,":[4],"quantify":[5],"and":[6,24,65,132,157,168,248,297,310,319,358,374,436],"characterise":[7],"the":[8,78,86,107,121,173,187,211,225,235,257,266,269,326,339,348,365,383,394,419,424,443,451,464],"full":[9],"complement":[10],"of":[11,22,30,48,59,96,106,124,149,164,175,196,210,217,239,242,251,268,282,289,354,385,400,417,423,434,438,459,470],"proteins":[12],"in":[13,93,199,380],"a":[14,19,37,162,181,240,274,287,432,460],"cell":[15],"or":[16,330],"organism":[17],"under":[18],"defined":[20],"set":[21],"conditions,":[23],"are":[25,88,116,312],"important":[26],"our":[28,147],"understanding":[29,148],"cellular":[31],"mechanisms.":[32],"However,":[33],"such":[34,386],"represent":[36],"major":[38],"analytical":[39],"challenge.":[40],"A":[41],"typical":[42],"proteome":[43],"analysis":[44,353],"involves":[45],"enzyme-mediated":[46],"digestion":[47,290],"complex":[49,57],"protein":[50,97],"mixtures":[51,109],"yield":[53],"an":[54],"even":[55],"more":[56],"mixture":[58],"peptides.":[60],"Combined":[61],"reverse-phase":[62],"liquid":[63],"chromatography":[64],"tandem":[66,125,165],"mass":[67,126,166,351],"spectrometry":[68,167],"is":[69,376,429,447],"then":[70],"traditionally":[71],"utilised":[72,232,315],"ascertain":[74],"sequence":[75,276,453],"information":[76],"from":[77,100,347],"characteristic":[79],"peptide":[80,108,130,158,176,243,275,283,401,440],"sequences.":[81,102,441],"Analytical":[82],"data":[83],"derived":[84,99],"for":[85],"peptides":[87,320,357],"employed":[89],"as":[90],"search":[91],"terms":[92],"database":[94],"searching":[95],"sequences":[98],"gene":[101],"The":[103,140,205,307,415],"extreme":[104],"complexity":[105],"analysed":[110],"means":[111],"that":[112,222,364],"additional":[113],"novel":[114,182],"approaches":[115],"required":[117],"fully":[119],"interrogate":[120],"vast":[122],"number":[123],"spectra":[127],"generated,":[128],"assigning":[129],"identity":[131],"thereby":[133],"helping":[134],"address":[136],"demanding":[137],"biological":[138],"questions.":[139],"research":[141],"reported":[142],"here":[143],"aims":[144],"further":[146],"both":[150,293,355,372],"gas":[151,260,420,444],"phase":[152,261,421,445],"peptide/peptide":[153,219],"fragment":[154,220,367,402],"ion":[155,169,177,221,262,368,403,473],"structure":[156],"fragmentation":[159,280],"behaviour":[160,281],"using":[161,186],"combination":[163,433],"mobility":[170],"measurement.To":[171],"facilitate":[172],"determination":[174,209],"collision":[178,214,236],"cross":[179,215,237],"section,":[180],"standard,":[183],"QCAL-IM,":[184],"produced":[185,245,255,285,321],"QconCAT":[188],"strategy,":[189],"has":[190,302,406],"been":[191,304,408],"developed":[192],"enable":[194],"calibration":[195,226],"drift":[197],"time":[198],"Travelling":[200],"Wave":[201],"Ion":[202],"Mobility":[203],"instruments.":[204],"standard":[206],"facilitates":[207],"empirical":[208],"rotationally":[212],"averaged":[213],"section":[216,238],"any":[218],"lies":[223],"within":[224,273],"range":[227,241],"encompassed.":[228],"QCAL-IM":[229],"was":[230],"subsequently":[231],"determine":[234],"ions":[244,284],"by":[246,286,322,382],"Lys-C":[247,311],"Lys-N":[249],"proteolysis":[250],"?standard?":[252],"proteins.":[253],"Data":[254],"allowed":[256],"effect":[258,416],"upon":[259],"conformation":[263],"through":[264,431],"changing":[265],"location":[267,384],"basic":[270,327,345,387],"residue":[271,428],"lysine":[272,331],"be":[278],"assessed.The":[279],"variety":[288],"regimes":[291],"during":[292,316,371,413],"collision-induced":[294],"dissociation":[295,300],"(CID)":[296],"electron":[298],"transfer":[299],"(ETD)":[301],"also":[303],"extensively":[305],"studied.":[306],"proteases":[308],"trypsin":[309],"those":[313],"typically":[314],"proteomic":[317],"each":[323],"have":[324],"either":[325],"residues":[328,346],"arginine":[329],"at":[332,378,463],"their":[333,359],"carboxy-terminus.":[334],"Secondary":[335],"enzymatic":[336],"treatment":[337],"with":[338],"exoprotease":[340],"carboxypeptidase":[341],"B":[342],"cleaves":[343],"these":[344],"C-terminus.":[349],"Tandem":[350],"spectrometric":[352],"tryptic/Lys-C":[356],"CBPB":[360],"truncated":[361],"analogue":[362],"highlights":[363],"dominant":[366],"series":[369],"observed":[370,452],"CID":[373],"ETD":[375],"determined,":[377],"least":[379],"part,":[381],"residues.Finally,":[388],"were":[390],"undertaken":[391],"investigate":[393],"factors":[395],"which":[396,405],"may":[397],"promote/inhibit":[398],"scrambling":[399,454],"sequence,":[404],"recently":[407],"shown":[409,448],"take":[411],"place":[412],"CID.":[414],"modifying":[418],"basicity":[422,446],"N-terminal":[425],"amino":[426],"acid":[427],"studied":[430],"derivatisation":[435],"synthesis":[437],"alternative":[439],"Increasing":[442],"inhibit":[450],"while":[455],"promoting":[456],"concomitant":[457],"rearrangement/retention":[458],"carboxyl":[461],"oxygen":[462],"C-terminus":[465],"give":[467],"enhanced":[468],"formation":[469],"bn+H2O":[471],"product":[472],"species.":[474]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
