{"id":"https://openalex.org/W772053929","doi":null,"title":"Age-related changes in prefrontal cortex function: links between sleep EEG and cognition","display_name":"Age-related changes in prefrontal cortex function: links between sleep EEG and cognition","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W772053929","mag":"772053929"},"language":"en","primary_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/8545","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/8545","pdf_url":"https://dspace.lboro.ac.uk/2134/8545","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.lboro.ac.uk/2134/8545","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005900286","display_name":"Clare E. Webb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Clare E. Webb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005900286"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.8539999723434448},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9649999737739563},{"id":"https://openalex.org/keywords/slow-wave-activity","display_name":"slow-wave activity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sleep-eeg","display_name":"sleep EEG","score":0.7350000143051147},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.8989999890327454},{"id":"https://openalex.org/keywords/social-cognition","display_name":"social cognition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ventromedial-prefrontal-cortex","display_name":"ventromedial prefrontal cortex","score":1.0},{"id":"https://openalex.org/keywords/tower-of-london","display_name":"Tower of London","score":0.6449999809265137},{"id":"https://openalex.org/keywords/verbal-fluency","display_name":"verbal fluency","score":0.9430000185966492},{"id":"https://openalex.org/keywords/emotional-prosody","display_name":"emotional prosody","score":0.9200000166893005},{"id":"https://openalex.org/keywords/healthy-older-adults","display_name":"healthy older adults","score":0.5299999713897705},{"id":"https://openalex.org/keywords/sleep-spindles","display_name":"sleep spindles","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7133033275604248},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.7053489685058594},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6825454235076904},{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.4988727569580078},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.4471292793750763},{"id":"https://openalex.org/C2780508717","wikidata":"https://www.wikidata.org/wiki/Q72788","display_name":"Dorsolateral prefrontal cortex","level":4,"score":0.43042275309562683},{"id":"https://openalex.org/C86658582","wikidata":"https://www.wikidata.org/wiki/Q1432778","display_name":"Social cognition","level":3,"score":0.4212311804294586},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.4191582202911377},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.40272149443626404},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3740403652191162},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.33016276359558105},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.309002548456192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14245149493217468}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.lboro.ac.uk:2134/8545","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/8545","pdf_url":"https://dspace.lboro.ac.uk/2134/8545","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:figshare.com:article/9607991","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Age-related_changes_in_prefrontal_cortex_function_links_between_sleep_EEG_and_cognition/9607991","pdf_url":null,"source":{"id":"https://openalex.org/S4306402585","display_name":"Loughborough University Research Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:772053929","doi":null,"is_oa":false,"landing_page_url":"https://repository.lboro.ac.uk/articles/Age-related_changes_in_prefrontal_cortex_function_links_between_sleep_EEG_and_cognition/9607991/files/17254484.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/8545","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/8545","pdf_url":"https://dspace.lboro.ac.uk/2134/8545","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W772053929.pdf","grobid_xml":"https://content.openalex.org/works/W772053929.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W81015993","https://openalex.org/W140808601","https://openalex.org/W197066864","https://openalex.org/W224070021","https://openalex.org/W586038166","https://openalex.org/W597766098","https://openalex.org/W1483126227","https://openalex.org/W1506869888","https://openalex.org/W1581387623","https://openalex.org/W1669563091","https://openalex.org/W1803658430","https://openalex.org/W1894134410","https://openalex.org/W1949141612","https://openalex.org/W1963859198","https://openalex.org/W1963945289","https://openalex.org/W1964407963","https://openalex.org/W1966555477","https://openalex.org/W1972709709","https://openalex.org/W1972852256","https://openalex.org/W1976725440","https://openalex.org/W1979101473","https://openalex.org/W1980095609","https://openalex.org/W1981628905","https://openalex.org/W1981639421","https://openalex.org/W1982311385","https://openalex.org/W1983805449","https://openalex.org/W1984137210","https://openalex.org/W1985564834","https://openalex.org/W1990139401","https://openalex.org/W1993303421","https://openalex.org/W1993315944","https://openalex.org/W1998704662","https://openalex.org/W2001254306","https://openalex.org/W2002115762","https://openalex.org/W2004973167","https://openalex.org/W2007683684","https://openalex.org/W2010801637","https://openalex.org/W2015661251","https://openalex.org/W2016801911","https://openalex.org/W2018285732","https://openalex.org/W2020389720","https://openalex.org/W2023802411","https://openalex.org/W2024655460","https://openalex.org/W2024707067","https://openalex.org/W2030517173","https://openalex.org/W2030934487","https://openalex.org/W2033997139","https://openalex.org/W2037358606","https://openalex.org/W2039752037","https://openalex.org/W2039845328","https://openalex.org/W2039850497","https://openalex.org/W2039991528","https://openalex.org/W2044071327","https://openalex.org/W2046140606","https://openalex.org/W2046602920","https://openalex.org/W2046717384","https://openalex.org/W2049061256","https://openalex.org/W2049369164","https://openalex.org/W2050304075","https://openalex.org/W2052471278","https://openalex.org/W2052610531","https://openalex.org/W2054468491","https://openalex.org/W2056709908","https://openalex.org/W2057662645","https://openalex.org/W2059148040","https://openalex.org/W2060823697","https://openalex.org/W2062596993","https://openalex.org/W2063681496","https://openalex.org/W2063805389","https://openalex.org/W2064777227","https://openalex.org/W2065433216","https://openalex.org/W2065445243","https://openalex.org/W2065483608","https://openalex.org/W2069114469","https://openalex.org/W2069947117","https://openalex.org/W2071394381","https://openalex.org/W2072646528","https://openalex.org/W2086415200","https://openalex.org/W2088470848","https://openalex.org/W2089030269","https://openalex.org/W2089054882","https://openalex.org/W2091359807","https://openalex.org/W2092170200","https://openalex.org/W2093532727","https://openalex.org/W2094768330","https://openalex.org/W2096937559","https://openalex.org/W2097617006","https://openalex.org/W2097653838","https://openalex.org/W2100484765","https://openalex.org/W2102585585","https://openalex.org/W2102988123","https://openalex.org/W2105234237","https://openalex.org/W2115404859","https://openalex.org/W2117800611","https://openalex.org/W2118009979","https://openalex.org/W2122639307","https://openalex.org/W2122738260","https://openalex.org/W2124599396","https://openalex.org/W2127430146","https://openalex.org/W2134551595","https://openalex.org/W2135784895","https://openalex.org/W2136170254","https://openalex.org/W2139119363","https://openalex.org/W2139602820","https://openalex.org/W2140295384","https://openalex.org/W2142004577","https://openalex.org/W2146091097","https://openalex.org/W2146288322","https://openalex.org/W2147954876","https://openalex.org/W2148491653","https://openalex.org/W2151137320","https://openalex.org/W2156102858","https://openalex.org/W2160068480","https://openalex.org/W2168147286","https://openalex.org/W2168502576","https://openalex.org/W2169731332","https://openalex.org/W2170131944","https://openalex.org/W2171305047","https://openalex.org/W2171776652","https://openalex.org/W2174944216","https://openalex.org/W2243700762","https://openalex.org/W2291694241","https://openalex.org/W2294320660","https://openalex.org/W2317543039","https://openalex.org/W2396228192","https://openalex.org/W2409720701","https://openalex.org/W2409868986","https://openalex.org/W2894865365","https://openalex.org/W3009610618","https://openalex.org/W3033503549","https://openalex.org/W3095205711","https://openalex.org/W4293077719"],"related_works":["https://openalex.org/W2891934397","https://openalex.org/W6907697936","https://openalex.org/W7036052087","https://openalex.org/W6998472544","https://openalex.org/W1982270965","https://openalex.org/W7055681130","https://openalex.org/W6999591379","https://openalex.org/W4393024109","https://openalex.org/W1491919902","https://openalex.org/W2398995288"],"abstract_inverted_index":{"Healthy":[0],"ageing":[1,40,237,260],"has":[2],"been":[3,22],"found":[4,306,318,354],"to":[5,45,68,79,107,178,366],"be":[6],"accompanied":[7],"by":[8],"changes":[9,20,57],"in":[10,25,58,128,286,311,341,355],"slow":[11],"wave":[12],"activity":[13],"(SWA)":[14],"and":[15,54,60,102,115,136,154,167,240,274,299,335,350],"cognitive":[16,39,61,117,145,236],"function.":[17],"Furthermore,":[18],"these":[19],"have":[21],"seen":[23],"predominantly":[24],"the":[26,34,75,87,96,99,179,188,193,206,209,215,244,275,314,320,367],"prefrontal":[27],"cortex":[28],"(PFC)":[29],"compared":[30],"to\\nother":[31],"regions":[32],"of":[33,38,49,52,74,98,156,162,174,199,221,223,235,246,268,288,324],"cortex.":[35],"Current":[36],"theories":[37],"propose":[41],"that\\nthis":[42],"occurs":[43],"due":[44,67],"a":[46,144,253,257],"specified":[47],"deterioration":[48,126],"neuronal":[50],"substrates":[51],"the\\nPFC,":[53],"as":[55,158,160,327],"such,":[56],"SWA":[59,85,345],"function":[62,110,118,149,176,294],"may":[63],"decline":[64],"at\\nsimilar":[65],"rates":[66],"similar":[69,124],"underlying":[70],"aetiology.\\nThe":[71],"main":[72],"aim":[73],"current":[76],"thesis":[77,248],"was":[78,272,280,317,346,364],"explore":[80],"age-related":[81,125,325],"differences":[82,204],"in\\nelectroencephalographic":[83],"(EEG)":[84],"during":[86],"first":[88],"NREM":[89],"period":[90],"and\\ncognitive":[91],"performance":[92,291],"that":[93],"relies":[94],"on":[95,192,218,250,292],"integrity":[97],"PFC:":[100],"executive\\nfunction":[101],"social":[103,116,163],"cognition.":[104],"The":[105,182,265],"extent":[106],"which":[108,363],"executive":[109,293],"(reliant\\non":[111],"dorsolateral":[112],"PFC":[113,121,175],"areas)":[114],"(reliant":[119],"on\\nventromedial":[120],"regions)":[122],"show":[123,241],"was\\ninvestigated":[127],"Study":[129,284,312,342],"1.":[130],"Here,":[131],"16":[132,137],"young":[133,216],"(22.2":[134],"years)":[135],"older":[138,183],"(71.5\\nyears)":[139],"adults":[140],"were":[141,353],"administered":[142],"with":[143,331],"testing":[146],"battery":[147],"including\\nexecutive":[148],"measures:":[150],"Verbal":[151],"Fluency":[152],"(VF)":[153],"Tower":[155],"London\\n(TOL);":[157],"well":[159],"measures":[161,173],"cognition:":[164],"Go/No-go,":[165],"Emotional\\nProsody":[166],"Ekman":[168],"60":[169,229],"Faces.":[170],"Not":[171],"all":[172],"were\\naffected":[177],"same":[180],"extent.":[181],"group":[184,217],"performed":[185,211],"significantly":[186,212],"worse\\non":[187],"TOL,":[189],"but":[190,208],"not":[191,202],"VF":[194,298,334],"test.":[195],"Additionally,":[196],"simple":[197],"aspects":[198],"social\\ncognition":[200],"did":[201],"display":[203],"between":[205],"groups,":[207],"older\\ngroup":[210],"worse":[213],"than":[214],"more":[219],"complex\\naspects":[220],"recognition":[222],"emotion":[224],"from":[225],"facial":[226],"expression":[227],"(Ekman":[228],"Faces)\\nand":[230],"Emotional":[231],"Prosody.\\nAs":[232],"most":[233,321],"studies":[234],"are":[238],"cross-sectional":[239,308],"large":[242],"agerelated\\nchanges,":[243],"remainder":[245],"this":[247,328],"focused":[249],"age-related\\nchanges":[251],"using":[252],"longitudinal":[254],"design":[255],"over":[256,339],"relatively":[258],"small":[259],"period\\n(mean":[261],"=":[262],"6.29":[263],"years).":[264],"average":[266,276],"age":[267,277],"participants":[269],"at":[270,278],"baseline":[271],"67.1\\nyears":[273],"follow-up":[279],"73.4":[281],"years.":[282],"In":[283],"2,":[285],"a\\nsample":[287],"11":[289],"participants,":[290],"tests":[295],"was\\nmeasured":[296],"(TOL,":[297],"Wisconsin":[300],"Card":[301],"Sorting":[302],"Test:":[303],"WCST).":[304],"As":[305],"in\\nthe":[307],"analyses":[309],"reported":[310],"1,":[313],"TOL":[315],"task":[316],"to\\nbe":[319],"sensitive":[322],"indicator":[323],"changes,":[326],"showed":[329],"a\\ndecline":[330],"age;":[332],"whereas,":[333],"WCST":[336],"remained":[337],"stable":[338],"time.\\nFurthermore,":[340],"3,":[343],"localised":[344,365],"recorded":[347],"via":[348],"EEG,":[349],"significant":[351],"declines":[352],"low":[356],"frequency":[357],"delta":[358],"(0.5":[359],"\u2013":[360],"1":[361],"Hz),":[362],"left":[368],"frontal":[369],"region.":[370],"(Continues...).":[371]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}