{"id":"https://openalex.org/W771997611","doi":null,"title":"Combining heterogeneous sources of data for the reverse-engineering of gene regulatory networks","display_name":"Combining heterogeneous sources of data for the reverse-engineering of gene regulatory networks","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W771997611","mag":"771997611"},"language":"en","primary_location":{"id":"pmh:oai:bura.brunel.ac.uk:2438/4203","doi":null,"is_oa":true,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/4203","pdf_url":"https://bura.brunel.ac.uk/bitstream/2438/4203/1/FulltextThesis.pdf","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://bura.brunel.ac.uk/bitstream/2438/4203/1/FulltextThesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004730348","display_name":"Emma Steele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emma Steele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004730348"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.9309999942779541},{"id":"https://openalex.org/keywords/reverse-engineering","display_name":"reverse engineering","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bayesian-networks","display_name":"Bayesian networks","score":0.902999997138977},{"id":"https://openalex.org/keywords/gene-expression-microarrays","display_name":"gene expression microarrays","score":0.6859999895095825},{"id":"https://openalex.org/keywords/multi-dataset-integration","display_name":"multi-dataset integration","score":0.5879999995231628},{"id":"https://openalex.org/keywords/network-learning","display_name":"network learning","score":0.36800000071525574},{"id":"https://openalex.org/keywords/data-heterogeneity","display_name":"data heterogeneity","score":0.4950000047683716},{"id":"https://openalex.org/keywords/network-robustness","display_name":"network robustness","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C207850805","wikidata":"https://www.wikidata.org/wiki/Q269608","display_name":"Reverse engineering","level":2,"score":0.7452462911605835},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6308184266090393},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6153203845024109},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5562143325805664},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5538806915283203},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.4803413152694702},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.44658970832824707},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38624969124794006},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3653850555419922},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33207178115844727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2521584630012512},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19937163591384888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18154603242874146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09822911024093628},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:bura.brunel.ac.uk:2438/4203","doi":null,"is_oa":true,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/4203","pdf_url":"https://bura.brunel.ac.uk/bitstream/2438/4203/1/FulltextThesis.pdf","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/963600","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/963600","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:771997611","doi":null,"is_oa":false,"landing_page_url":"https://bura.brunel.ac.uk/bitstream/2438/4203/1/FulltextThesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bura.brunel.ac.uk:2438/4203","doi":null,"is_oa":true,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/4203","pdf_url":"https://bura.brunel.ac.uk/bitstream/2438/4203/1/FulltextThesis.pdf","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W771997611.pdf","grobid_xml":"https://content.openalex.org/works/W771997611.grobid-xml"},"referenced_works_count":147,"referenced_works":["https://openalex.org/W89551800","https://openalex.org/W291356173","https://openalex.org/W376961572","https://openalex.org/W957639803","https://openalex.org/W1482401268","https://openalex.org/W1484965326","https://openalex.org/W1491494711","https://openalex.org/W1514437925","https://openalex.org/W1529149406","https://openalex.org/W1531743498","https://openalex.org/W1554745858","https://openalex.org/W1556472699","https://openalex.org/W1583942422","https://openalex.org/W1588313728","https://openalex.org/W1590398161","https://openalex.org/W1601753016","https://openalex.org/W1603903339","https://openalex.org/W1604959358","https://openalex.org/W1626295059","https://openalex.org/W1631749243","https://openalex.org/W1650504959","https://openalex.org/W1739940154","https://openalex.org/W1753000577","https://openalex.org/W1826153834","https://openalex.org/W1851422093","https://openalex.org/W1896341954","https://openalex.org/W1967411964","https://openalex.org/W1971224531","https://openalex.org/W1976208596","https://openalex.org/W1978319180","https://openalex.org/W1981307375","https://openalex.org/W1981933378","https://openalex.org/W1989371635","https://openalex.org/W1990275499","https://openalex.org/W1990987722","https://openalex.org/W1992794281","https://openalex.org/W1995945562","https://openalex.org/W2003170555","https://openalex.org/W2007945980","https://openalex.org/W2010637767","https://openalex.org/W2013444425","https://openalex.org/W2022441134","https://openalex.org/W2024081693","https://openalex.org/W2025803032","https://openalex.org/W2034784092","https://openalex.org/W2035450351","https://openalex.org/W2042016758","https://openalex.org/W2044525257","https://openalex.org/W2053126761","https://openalex.org/W2061572799","https://openalex.org/W2061666330","https://openalex.org/W2064802889","https://openalex.org/W2065912508","https://openalex.org/W2069799701","https://openalex.org/W2070678529","https://openalex.org/W2080182143","https://openalex.org/W2081980086","https://openalex.org/W2083079645","https://openalex.org/W2085617857","https://openalex.org/W2090554117","https://openalex.org/W2098453858","https://openalex.org/W2100603120","https://openalex.org/W2102406695","https://openalex.org/W2103014023","https://openalex.org/W2103453943","https://openalex.org/W2104171413","https://openalex.org/W2104877015","https://openalex.org/W2107328434","https://openalex.org/W2107923541","https://openalex.org/W2108420379","https://openalex.org/W2108579152","https://openalex.org/W2109363337","https://openalex.org/W2110280725","https://openalex.org/W2110575115","https://openalex.org/W2112717966","https://openalex.org/W2113677269","https://openalex.org/W2113836695","https://openalex.org/W2115504560","https://openalex.org/W2117625122","https://openalex.org/W2120969766","https://openalex.org/W2121906195","https://openalex.org/W2121995533","https://openalex.org/W2123060905","https://openalex.org/W2124617249","https://openalex.org/W2126602684","https://openalex.org/W2127218421","https://openalex.org/W2128298129","https://openalex.org/W2132561013","https://openalex.org/W2133111499","https://openalex.org/W2136000097","https://openalex.org/W2136549265","https://openalex.org/W2136988691","https://openalex.org/W2137683543","https://openalex.org/W2137883630","https://openalex.org/W2139083403","https://openalex.org/W2139807849","https://openalex.org/W2140176439","https://openalex.org/W2140601463","https://openalex.org/W2141146725","https://openalex.org/W2141842620","https://openalex.org/W2142182986","https://openalex.org/W2142199854","https://openalex.org/W2142305821","https://openalex.org/W2142460132","https://openalex.org/W2142635246","https://openalex.org/W2143891888","https://openalex.org/W2144106004","https://openalex.org/W2144344817","https://openalex.org/W2145394518","https://openalex.org/W2145525243","https://openalex.org/W2146855196","https://openalex.org/W2146856779","https://openalex.org/W2148758061","https://openalex.org/W2149310258","https://openalex.org/W2149579404","https://openalex.org/W2150926065","https://openalex.org/W2152155643","https://openalex.org/W2152205088","https://openalex.org/W2153961603","https://openalex.org/W2153999032","https://openalex.org/W2155205047","https://openalex.org/W2156031219","https://openalex.org/W2157825442","https://openalex.org/W2158292827","https://openalex.org/W2158940923","https://openalex.org/W2159080219","https://openalex.org/W2159203162","https://openalex.org/W2159482845","https://openalex.org/W2160533336","https://openalex.org/W2163296862","https://openalex.org/W2163456090","https://openalex.org/W2165011536","https://openalex.org/W2167155713","https://openalex.org/W2167190345","https://openalex.org/W2168020168","https://openalex.org/W2170524079","https://openalex.org/W2367464035","https://openalex.org/W2504533704","https://openalex.org/W2522519459","https://openalex.org/W2538024783","https://openalex.org/W2611370172","https://openalex.org/W2767905780","https://openalex.org/W2974701791","https://openalex.org/W2979006918","https://openalex.org/W3015571647","https://openalex.org/W3133236490","https://openalex.org/W3149838063"],"related_works":["https://openalex.org/W1487738193","https://openalex.org/W6950317014","https://openalex.org/W2128310384","https://openalex.org/W176951647","https://openalex.org/W4392850779","https://openalex.org/W1511647184","https://openalex.org/W2131550814","https://openalex.org/W2551976455","https://openalex.org/W18177240","https://openalex.org/W2281065435"],"abstract_inverted_index":{"Gene":[0],"Regulatory":[1],"Networks":[2],"(GRNs)":[3],"represent":[4],"how":[5,14],"genes":[6,21,61],"interact":[7],"in":[8,66,87],"various":[9],"cellular":[10],"processes":[11],"by":[12],"describing":[13],"the":[15,24,27,44,56,88,105,116],"expression":[16,25,57,76],"level,":[17],"or":[18],"activity,":[19],"of":[20,26,48,58,60,74,85,90,98,107,118],"can":[22,32],"affect":[23],"other":[28],"genes.Reverseengineering":[29],"GRN":[30,91],"models":[31],"help":[33],"biologists":[34],"understand":[35],"and":[36,42,81,115],"gain":[37],"insight":[38],"into":[39],"genetic":[40],"conditions":[41],"diseases.Recently,":[43],"increasingly":[45],"widespread":[46],"use":[47],"DNA":[49],"microarrays,":[50],"a":[51,82,96,101],"high-throughput":[52],"technology":[53,94],"that":[54],"allows":[55],"thousands":[59],"to":[62,71,110],"be":[63],"measured":[64],"simultaneously":[65],"biological":[67],"experiments,":[68],"has":[69,95],"led":[70],"many":[72],"datasets":[73],"gene":[75],"measurements":[77],"becoming":[78],"publicly":[79],"available":[80],"subsequent":[83],"explosion":[84],"research":[86],"reverse-engineering":[89],"models.However,":[92],"microarray":[93],"number":[97],"limitations":[99],"as":[100],"data":[102],"source":[103],"for":[104],"modelling":[106],"GRNs,":[108],"due":[109],"concerns":[111],"over":[112],"its":[113],"reliability":[114],"reproducibility":[117],"experimental":[119],"results.":[120]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}