{"id":"https://openalex.org/W77139702","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.2","title":"Identification of a conserved self-antigen bearing the 2F5 neutralizing epitope of the HIV-1 gp41 Membrane Proximal External Region (105.2)","display_name":"Identification of a conserved self-antigen bearing the 2F5 neutralizing epitope of the HIV-1 gp41 Membrane Proximal External Region (105.2)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W77139702","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.2","mag":"77139702"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.105.2","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.105.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031502585","display_name":"Guang Yang","orcid":"https://orcid.org/0000-0003-4377-1836","observed_orcids":["https://orcid.org/0000-0003-4377-1836"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang Yang","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112887982","display_name":"T. Matt Holl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Holl","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102985039","display_name":"Yang Liu","orcid":"https://orcid.org/0009-0004-5331-5337","observed_orcids":["https://orcid.org/0009-0004-5331-5337"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014493738","display_name":"Xiaozhi Lu","orcid":"https://orcid.org/0000-0002-2517-6331","observed_orcids":["https://orcid.org/0000-0002-2517-6331"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaozhi Lu","raw_affiliation_strings":["Human Vaccine Institute, Duke University , Durham, NC","2Human Vaccine Institute, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Vaccine Institute, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"2Human Vaccine Institute, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067541140","display_name":"Nathan I. Nicely","orcid":"https://orcid.org/0000-0002-0025-2377","observed_orcids":["https://orcid.org/0000-0002-0025-2377"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Nicely","raw_affiliation_strings":["Human Vaccine Institute, Duke University , Durham, NC","2Human Vaccine Institute, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Vaccine Institute, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"2Human Vaccine Institute, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047959968","display_name":"Thomas B. Kepler","orcid":"https://orcid.org/0000-0002-1383-6865","observed_orcids":["https://orcid.org/0000-0002-1383-6865"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Kepler","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Duke University , Durham, NC","Department of Immunology, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC","3Department of Biostatistics and Bioinformatics, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"3Department of Biostatistics and Bioinformatics, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027270152","display_name":"S. Munir Alam","orcid":"https://orcid.org/0000-0003-0941-0703","observed_orcids":["https://orcid.org/0000-0003-0941-0703"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Alam","raw_affiliation_strings":["Human Vaccine Institute, Duke University , Durham, NC","2Human Vaccine Institute, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Vaccine Institute, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"2Human Vaccine Institute, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032122826","display_name":"Hua\u2010Xin Liao","orcid":"https://orcid.org/0000-0002-7871-1334","observed_orcids":["https://orcid.org/0000-0002-7871-1334"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua-xin Liao","raw_affiliation_strings":["Human Vaccine Institute, Duke University , Durham, NC","2Human Vaccine Institute, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Vaccine Institute, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"2Human Vaccine Institute, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025128691","display_name":"Leonard D. Spicer","orcid":"https://orcid.org/0000-0001-5655-0093","observed_orcids":["https://orcid.org/0000-0001-5655-0093"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Spicer","raw_affiliation_strings":["Department of Biochemistry, Duke University , Durham, NC","4Department of Biochemistry, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"4Department of Biochemistry, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051827275","display_name":"Barton F. Haynes","orcid":"https://orcid.org/0000-0002-7643-9023","observed_orcids":["https://orcid.org/0000-0002-7643-9023","https://orcid.org/0000-0002-2847-1854"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barton Haynes","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC","Human Vaccine Institute, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC","2Human Vaccine Institute, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Human Vaccine Institute, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"2Human Vaccine Institute, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065001474","display_name":"Garnett H. Kelsoe","orcid":"https://orcid.org/0000-0002-8770-040X","observed_orcids":["https://orcid.org/0000-0002-8770-040X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garnett Kelsoe","raw_affiliation_strings":["Department of Immunology, Duke University , Durham, NC","1Department of Immunology, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Department of Immunology, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"105.2","last_page":"105.2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/2f5-antibody","display_name":"2F5 antibody","score":0.9129999876022339},{"id":"https://openalex.org/keywords/neutralizing-epitopes","display_name":"neutralizing epitopes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/membrane-proximal-external-region","display_name":"membrane-proximal external region","score":0.8690000176429749},{"id":"https://openalex.org/keywords/gp41","display_name":"gp41","score":0.9729999899864197},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.7820000052452087},{"id":"https://openalex.org/keywords/kynureninase","display_name":"kynureninase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/polyreactive-antibodies","display_name":"polyreactive antibodies","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.8339999914169312},{"id":"https://openalex.org/keywords/epitope-mimicry","display_name":"epitope mimicry","score":0.6959999799728394},{"id":"https://openalex.org/keywords/knock-in-mice","display_name":"knock-in mice","score":0.5759999752044678},{"id":"https://openalex.org/keywords/hiv-1-envelope","display_name":"HIV-1 envelope","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.854981541633606},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.751232922077179},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6347679495811462},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5893969535827637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5598724484443665},{"id":"https://openalex.org/C2776258796","wikidata":"https://www.wikidata.org/wiki/Q5590520","display_name":"Gp41","level":4,"score":0.5480358004570007},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5115278959274292},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.49927186965942383},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44825479388237},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39299774169921875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21545758843421936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16333737969398499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15238383412361145}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.105.2","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.105.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1550553562","https://openalex.org/W2136489732","https://openalex.org/W1027395374","https://openalex.org/W4313386662","https://openalex.org/W2560786168","https://openalex.org/W4313385633","https://openalex.org/W4205772766","https://openalex.org/W2159565850","https://openalex.org/W2139978152","https://openalex.org/W2156841733"],"abstract_inverted_index":{"Abstract":[0],"Accumulating":[1],"evidence":[2],"suggests":[3,198],"that":[4,26,57,77,91,199],"the":[5,44,80,92,135,143],"efficient":[6],"generation":[7],"of":[8,20,30,43,60,70,99,114,131,139,180,188,201,209],"neutralizing":[9,71],"HIV-1":[10,31,81,184],"antibody":[11,94,159],"may":[12,203],"be":[13],"proscribed":[14],"by":[15],"immunological":[16,61,64],"tolerance.":[17,62],"The":[18,157,186],"majority":[19],"monoclonal":[21],"human":[22,104,174],"antibodies,":[23],"including":[24,106],"2F5,":[25],"neutralize":[27],"multiple":[28],"clades":[29],"are":[32,84],"polyreactive":[33],"and":[34,41,103,148,160,170,195],"bind":[35,165],"avidly":[36],"to":[37,183],"mammalian":[38,140],"cells.":[39],"Introduction":[40],"expression":[42,69],"2F5":[45,82,93,145,155,158,181],"VDJ":[46],"rearrangement":[47],"in":[48,52,86],"knock-in":[49],"mice":[50],"results":[51],"a":[53,96,107,111,128,205],"B-cell":[54],"developmental":[55],"blockade":[56],"is":[58,176],"characteristic":[59],"If":[63],"tolerance":[65],"does":[66],"prevent":[67],"regular":[68],"2F5-like":[72],"antibody,":[73],"then":[74],"discrete":[75],"autoantigens":[76],"structurally":[78],"mimic":[79],"epitope":[83,146],"present":[85],"mammals.":[87],"Here,":[88],"we":[89],"demonstrate":[90],"precipitates":[95],"small":[97],"number":[98],"proteins":[100],"from":[101],"mouse":[102],"cells,":[105],"major":[108],"component":[109,130],"with":[110,167],"molecular":[112],"mass":[113],"about":[115],"50":[116,122],"kDa.":[117],"We":[118],"have":[119],"identified":[120],"this":[121,151],"kDa":[123],"protein":[124],"as":[125,190],"kynureninase":[126],"(KYNU),":[127],"conserved":[129,136],"tryptophan":[132],"metabolism.":[133],"Remarkably,":[134],"H3":[137],"domain":[138],"KYNU":[141,166,175,189],"contains":[142],"core":[144],"(ELDKWA),":[147],"mutation":[149],"within":[150],"region":[152],"greatly":[153],"diminishes":[154],"binding.":[156],"its":[161],"inferred,":[162],"unmutated":[163],"precursor":[164],"high":[168],"affinity":[169],"specificity.":[171],"Indeed,":[172],"recombinant":[173],"an":[177],"effective":[178],"inhibitor":[179],"binding":[182],"envelope.":[185],"nature":[187],"autoantigen":[191],"was":[192],"previously":[193],"unknown":[194],"our":[196],"study":[197],"mimicry":[200],"self-antigens":[202],"represent":[204],"general":[206],"evolutionary":[207],"strategy":[208],"viral":[210],"pathogens.":[211]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
