{"id":"https://openalex.org/W771346764","doi":null,"title":"Characterization and in vitro/in vivo dissolution of nab-paclitaxel nanoparticles","display_name":"Characterization and in vitro/in vivo dissolution of nab-paclitaxel nanoparticles","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W771346764","mag":"771346764"},"language":"en","primary_location":{"id":"mag:771346764","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/68/9_Supplement/5624.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112516025","display_name":"Neil P. Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166201","display_name":"Abraxis (United States)","ror":"https://ror.org/05r1gew95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Desai","raw_affiliation_strings":["Abraxis BioScience, Inc., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abraxis BioScience, Inc., Los Angeles, CA","institution_ids":["https://openalex.org/I4210166201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110297083","display_name":"Tapas De","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166201","display_name":"Abraxis (United States)","ror":"https://ror.org/05r1gew95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. K. De","raw_affiliation_strings":["Abraxis BioScience, Inc., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abraxis BioScience, Inc., Los Angeles, CA","institution_ids":["https://openalex.org/I4210166201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026694235","display_name":"Sherry Ci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166201","display_name":"Abraxis (United States)","ror":"https://ror.org/05r1gew95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry Ci","raw_affiliation_strings":["Abraxis BioScience, Inc., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abraxis BioScience, Inc., Los Angeles, CA","institution_ids":["https://openalex.org/I4210166201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110400575","display_name":"Leslie G. Louie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166201","display_name":"Abraxis (United States)","ror":"https://ror.org/05r1gew95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Louie","raw_affiliation_strings":["Abraxis BioScience, Inc., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abraxis BioScience, Inc., Los Angeles, CA","institution_ids":["https://openalex.org/I4210166201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059615305","display_name":"Vuong N. Trieu","orcid":"https://orcid.org/0000-0002-6675-0811","observed_orcids":["https://orcid.org/0000-0002-6675-0811"]},"institutions":[{"id":"https://openalex.org/I4210166201","display_name":"Abraxis (United States)","ror":"https://ror.org/05r1gew95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vuong Trieu","raw_affiliation_strings":["Abraxis BioScience, Inc., Los Angeles, CA"],"raw_orcid":"https://orcid.org/0000-0002-6675-0811","affiliations":[{"raw_affiliation_string":"Abraxis BioScience, Inc., Los Angeles, CA","institution_ids":["https://openalex.org/I4210166201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210166201"],"apc_list":null,"apc_paid":null,"fwci":0.2857,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55886214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"68","issue":null,"first_page":"5624","last_page":"5624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nanoparticle-dissolution","display_name":"nanoparticle dissolution","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pig-plasma","display_name":"pig plasma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.5759999752044678},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/minipig-model","display_name":"minipig model","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.8546742796897888},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6323437690734863},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.5790352821350098},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5612704753875732},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4909208416938782},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4866257607936859},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4300300180912018},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.39305737614631653},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36077338457107544},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3259480595588684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20615875720977783},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.17102524638175964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14159277081489563},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11115679144859314},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08132496476173401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06755203008651733},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:771346764","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/68/9_Supplement/5624.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3120573232","https://openalex.org/W7203706025","https://openalex.org/W2586286736","https://openalex.org/W3159715360","https://openalex.org/W1530886505","https://openalex.org/W2548947765","https://openalex.org/W2144378910","https://openalex.org/W2060597541","https://openalex.org/W4402894084","https://openalex.org/W2035419569"],"abstract_inverted_index":{"5624":[0],"Background:":[2],"Nab-paclitaxel":[3,71],"(Abraxane\u00ae)":[4],"is":[5,351,362],"a":[6,160,213,303],"nanoparticle":[7,190],"albumin-bound":[8],"injectable":[9],"form":[10],"of":[11,14,162,193,275,282,312,368],"paclitaxel":[12,34,206,276],"free":[13],"toxic":[15],"solvents.":[16],"In":[17,236,270],"preclinical":[18],"and":[19,27,55,65,85,116,181,200,216,263,293,377,384],"clinical":[20],"studies,":[21],"nab-paclitaxel":[22,53,95,154,222,246,283,315,325],"exhibited":[23],"superior":[24],"antitumor":[25],"efficacy":[26],"improved":[28],"safety":[29],"profile":[30],"compared":[31],"to":[32,106,125,210,233,251,380],"cremophor-based":[33],"(Taxol)":[35],"(Desai":[36],"et":[37,44],"al.,":[38,45],"Clinical":[39,47],"Cancer":[40],"Research,":[41],"2006;":[42],"Gradishar":[43],"J":[46],"Oncology,":[48],"2005).":[49],"This":[50],"study":[51,239],"characterized":[52,74],"nanoparticles":[54,72,209,223,247,306,326,335,370],"investigated":[56],"their":[57],"fate":[58],"in":[59,61,66,68,91,99,109,147,175,207,212,255,260,266,277,358],"vitro":[60,92,237],"simulated":[62,110,256],"plasma":[63,111,115,126],"solution":[64],"vivo":[67,148],"pigs.\u2028":[69],"Methods:":[70],"were":[73,177,291,307],"by":[75,127,139,179,186,198],"transmission":[76],"electro":[77],"microscopy":[78],"(TEM),":[79],"dynamic":[80],"laser":[81],"light":[82],"scattering":[83],"(DLS)":[84],"X-ray":[86],"diffraction":[87],"(XRD).":[88],"For":[89,145],"the":[90,146,205,208,241,272,280,299,344,354,365,369,375],"dissolution":[93,149,238,300,355,367],"study,":[94,150,360],"suspension":[96],"(5":[97],"mg/mL":[98],"0.9%":[100],"sodium":[101],"chloride":[102],"solution)":[103],"was":[104,123,137,184,196],"diluted":[105],"different":[107],"concentrations":[108,174,243,274],"(5%":[112],"HSA),":[113],"pig":[114,117,121,261,267],"whole":[118,268],"blood.":[119,269],"The":[120,189],"blood":[122,176,310],"processed":[124],"centrifugation":[128],"at":[129,159,284,317,337],"3000":[130],"rpm":[131],"for":[132],"15":[133],"minutes.":[134,172],"Particle":[135],"size":[136,183,192,231],"measured":[138,185],"DLS":[140],"with":[141,230,333],"Malvern":[142],"Zetasizer":[143],"3000.":[144],"Yucatan":[151],"mini-pigs":[152],"received":[153],"via":[155,374],"ear":[156],"vein":[157],"infusion":[158,281],"dose":[161],"either":[163],"300":[164,285],"mg/m2":[165,286,290],"or":[166,288],"900":[167,289],"mg/m2,":[168],"administered":[169],"over":[170],"30":[171],"Paclitaxel":[173],"determined":[178,197,204,240,357],"HPLC,":[180],"particle":[182],"DLS.\u2028":[187],"Results:":[188],"mean":[191],"130":[194],"nm":[195],"TEM":[199],"DLS.":[201],"XRD":[202],"studies":[203],"be":[211],"non-crystalline,":[214],"amorphous,":[215],"readily":[217],"bioavailable":[218],"state.":[219],"Upon":[220,322],"dilution,":[221],"quickly":[224],"dissociated":[225],"into":[226,329],"soluble":[227,330],"albumin-paclitaxel":[228,331],"complexes":[229,332],"similar":[232],"native":[234],"albumin.":[235],"threshold":[242,356],"below":[244,298,353],"which":[245],"would":[248],"rapidly":[249,327],"dissolve":[250],"be:":[252],"50-60":[253],"\u00b5g/mL":[254,259,265],"plasma,":[257,262],"100":[258],"150":[264],"vivo,":[271],"peak":[273],"circulation":[278],"following":[279],"(MTD)":[287],"10.5":[292],"31.4":[294],"\u00b5g/mL,":[295],"respectively,":[296],"well":[297,352],"threshold.":[301],"As":[302],"result,":[304],"no":[305,334],"detected":[308,336],"from":[309],"samples":[311],"pigs":[313],"receiving":[314],"administration":[316],"any":[318,338],"time":[319,339],"point.\u2028":[320],"Conclusion:":[321],"infusion,":[323],"amorphous":[324],"dissolved":[328],"point":[340],"post":[341],"infusion.":[342],"Since":[343],"previously":[345],"reported":[346],"human":[347],"Cmax":[348],"(23":[349],"\u00b5g/mL)":[350],"this":[359],"it":[361],"believed":[363],"that":[364],"rapid":[366],"can":[371],"facilitate":[372],"transport":[373],"gp60":[376],"SPARC":[378],"pathways":[379],"enhance":[381],"drug":[382],"delivery":[383],"tumor":[385],"targeting.":[386]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}