{"id":"https://openalex.org/W77037165","doi":null,"title":"Movements of cultured corneal epithelial cells and stromal fibroblasts in electric fields.","display_name":"Movements of cultured corneal epithelial cells and stromal fibroblasts in electric fields.","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W77037165","mag":"77037165","pmid":"https://pubmed.ncbi.nlm.nih.gov/2242993"},"language":"en","primary_location":{"id":"pmid:2242993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2242993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059503929","display_name":"H. Kaz Soong","orcid":"https://orcid.org/0000-0002-2941-6910","observed_orcids":["https://orcid.org/0000-0002-2941-6910"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H K Soong","raw_affiliation_strings":["Department of Ophthalmology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005907020","display_name":"William C. Parkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W C Parkinson","raw_affiliation_strings":["Department of Ophthalmology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009304913","display_name":"Shamik Bafna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Bafna","raw_affiliation_strings":["Department of Ophthalmology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017479215","display_name":"Gregory L. Sulik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G L Sulik","raw_affiliation_strings":["Department of Ophthalmology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104280720","display_name":"Siying Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S C Huang","raw_affiliation_strings":["Department of Ophthalmology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9017,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.6856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"11","first_page":"2278","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.329800009727478,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.329800009727478,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.07410000264644623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galvanotropism","display_name":"galvanotropism","score":0.8259999752044678},{"id":"https://openalex.org/keywords/galvanotaxis","display_name":"galvanotaxis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/electrical-field-stimulation","display_name":"electrical field stimulation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/corneal-stromal-fibroblasts","display_name":"corneal stromal fibroblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-morphology-changes","display_name":"cell shape changes","score":0.5569999814033508},{"id":"https://openalex.org/keywords/lamellipodia","display_name":"lamellipodia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.9120000004768372},{"id":"https://openalex.org/keywords/rabbit-cornea","display_name":"rabbit cornea","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.8721147775650024},{"id":"https://openalex.org/C60799052","wikidata":"https://www.wikidata.org/wiki/Q46221","display_name":"Electric field","level":2,"score":0.6951644420623779},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4837908446788788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4676090478897095},{"id":"https://openalex.org/C109185818","wikidata":"https://www.wikidata.org/wiki/Q3092607","display_name":"Lamellipodium","level":4,"score":0.4608535170555115},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.45002490282058716},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.44150298833847046},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.441329687833786},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.413329154253006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4002046585083008},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34188520908355713},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.3270488381385803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30452823638916016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21357721090316772},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18934699892997742},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13252529501914978},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10985282063484192},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06993749737739563},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010781","descriptor_name":"Photography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2242993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2242993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:77037165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2242993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8444406384","display_name":"RESPONSE OF CORNEAL CELL MOVEMENT IN ELECTRIC FIELDS","funder_award_id":"R03EY008339","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W59461318","https://openalex.org/W175929622","https://openalex.org/W1837918829","https://openalex.org/W1982256640","https://openalex.org/W2006668689","https://openalex.org/W2039900497","https://openalex.org/W2049744505","https://openalex.org/W2125254905","https://openalex.org/W2185472483"],"related_works":["https://openalex.org/W2468231511","https://openalex.org/W2142628305","https://openalex.org/W2010446007","https://openalex.org/W1893720466","https://openalex.org/W2082517806","https://openalex.org/W2110284381","https://openalex.org/W62397964","https://openalex.org/W3172486591","https://openalex.org/W1990804592","https://openalex.org/W2133865929"],"abstract_inverted_index":{"The":[0,57],"effects":[1],"of":[2,12,26,81,110,122,137,142,176],"an":[3,31,78],"externally":[4],"applied":[5,54],"direct-current":[6],"electric":[7,32,55,58,154],"field":[8,59,135,155],"on":[9],"the":[10,53,95,103,119,131,153,174],"movement":[11],"cultured":[13],"rabbit":[14],"corneal":[15,177],"epithelial":[16,35,66,90],"cells":[17,36,67,91,124],"and":[18,37,43,68,73,99,114,125,149],"stromal":[19,38,69,100],"fibroblasts":[20,39,70,101],"were":[21,71,116],"studied.":[22],"After":[23,77],"a":[24],"latency":[25,80],"approximately":[27],"20":[28],"minutes":[29],"in":[30,65,94,102,173],"field,":[33],"both":[34,84,108],"became":[40],"spindle":[41],"shaped":[42],"underwent":[44,128],"galvanotropism":[45],"by":[46,146],"aligning":[47],"their":[48],"long":[49],"axes":[50],"perpendicular":[51],"to":[52,152],"field.":[56],"stimulus":[60],"thresholds":[61],"for":[62],"galvanotropic":[63],"movements":[64],"4V/cm":[72],"6":[74],"V/cm,":[75,140],"respectively.":[76],"additional":[79],"30":[82],"minutes,":[83],"cell":[85,126],"types":[86,109],"manifested":[87],"galvanotaxic":[88,167],"movements:":[89],"commenced":[92],"migration":[93],"cathodal":[96],"(downfield)":[97],"direction":[98],"anodal":[104],"(upfield)":[105],"direction.":[106],"For":[107],"cells,":[111],"ruffled":[112],"membranes":[113],"lamellipodia":[115],"abundant":[117],"at":[118,130],"leading":[120],"edges":[121],"migrating":[123],"processes":[127],"retraction":[129],"trailing":[132],"edges.":[133],"At":[134],"strengths":[136],"above":[138],"10":[139],"evidence":[141],"cellular":[143,147],"damage":[144],"(manifested":[145],"rounding":[148],"detachment),":[150],"attributable":[151],"treatment,":[156],"was":[157],"observed":[158],"after":[159],"4":[160],"hours.":[161],"These":[162],"preliminary":[163],"results":[164],"suggest":[165],"that":[166],"responses":[168],"could":[169],"be":[170],"exploited":[171],"clinically":[172],"enhancement":[175],"wound":[178],"healing.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}