{"id":"https://openalex.org/W770360449","doi":"https://doi.org/10.1042/bj1840303","title":"The stimulus\u2013secretion coupling 4-methyl-2-oxopentanoate-induced insulin release","display_name":"The stimulus\u2013secretion coupling 4-methyl-2-oxopentanoate-induced insulin release","publication_year":1979,"publication_date":"1979-11-15","ids":{"openalex":"https://openalex.org/W770360449","doi":"https://doi.org/10.1042/bj1840303","mag":"770360449","pmid":"https://pubmed.ncbi.nlm.nih.gov/43144","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1161765"},"language":"en","primary_location":{"id":"doi:10.1042/bj1840303","doi":"https://doi.org/10.1042/bj1840303","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1840303","pdf_url":"https://portlandpress.com/biochemj/article-pdf/184/2/303/783293/bj1840303.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/184/2/303/783293/bj1840303.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111609135","display_name":"JOHN C. HUTTON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J C Hutton","raw_affiliation_strings":["Department ofClinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K","Laboratory ofExperimental Medicine, University of Brussels, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofClinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K","institution_ids":["https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Laboratory ofExperimental Medicine, University of Brussels, Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103055230","display_name":"Abdullah Sener","orcid":"https://orcid.org/0000-0003-2718-5423","observed_orcids":["https://orcid.org/0000-0003-2718-5423"]},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Sener","raw_affiliation_strings":["Laboratory ofExperimental Medicine, University of Brussels, Brussels, Belgium","Department ofClinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory ofExperimental Medicine, University of Brussels, Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Department ofClinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020829082","display_name":"Willy Jean Malaisse","orcid":"https://orcid.org/0000-0003-0375-7036","observed_orcids":["https://orcid.org/0000-0003-0375-7036"]},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W J Malaisse","raw_affiliation_strings":["Laboratory ofExperimental Medicine, University of Brussels, Brussels, Belgium","Department ofClinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory ofExperimental Medicine, University of Brussels, Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Department ofClinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, U.K","institution_ids":["https://openalex.org/I4210156194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156194"],"apc_list":null,"apc_paid":null,"fwci":5.0832,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.95099455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"184","issue":"2","first_page":"303","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7760000228881836},{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8980000019073486},{"id":"https://openalex.org/keywords/calcium-uptake","display_name":"calcium uptake","score":0.6930000185966492},{"id":"https://openalex.org/keywords/atp-adp-ratio","display_name":"ATP/ADP ratio","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adenylate-energy-charge","display_name":"energy charge","score":0.734000027179718},{"id":"https://openalex.org/keywords/nad-nadh-ratio","display_name":"NAD+/NADH ratio","score":0.906000018119812},{"id":"https://openalex.org/keywords/nadph-nadp-ratio","display_name":"NADPH/NADP+ ratio","score":0.9179999828338623},{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.6809999942779541},{"id":"https://openalex.org/keywords/ammonium","display_name":"ammonium","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7867686152458191},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5685802698135376},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5485268235206604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5259102582931519},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5228605270385742},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.470826655626297},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44398555159568787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4146736264228821},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39480215311050415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3378170132637024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30136004090309143},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09885391592979431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000643","descriptor_name":"Ammonium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012636","descriptor_name":"Secretory Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014631","descriptor_name":"Valerates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj1840303","doi":"https://doi.org/10.1042/bj1840303","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1840303","pdf_url":"https://portlandpress.com/biochemj/article-pdf/184/2/303/783293/bj1840303.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:43144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1161765","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1161765/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/79431","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/79431","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical journal, 184 (2","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1042/bj1840303","doi":"https://doi.org/10.1042/bj1840303","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1840303","pdf_url":"https://portlandpress.com/biochemj/article-pdf/184/2/303/783293/bj1840303.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320320870","display_name":"European Foundation for the Study of Diabetes","ror":"https://ror.org/05tgz4m05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W770360449.pdf","grobid_xml":"https://content.openalex.org/works/W770360449.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W789371541","https://openalex.org/W1535979687","https://openalex.org/W1569813716","https://openalex.org/W1607256394","https://openalex.org/W1769099734","https://openalex.org/W1885526108","https://openalex.org/W1970643756","https://openalex.org/W1976552734","https://openalex.org/W1981561049","https://openalex.org/W1986273448","https://openalex.org/W1998413052","https://openalex.org/W2020203890","https://openalex.org/W2025709760","https://openalex.org/W2026794546","https://openalex.org/W2052930284","https://openalex.org/W2072594154","https://openalex.org/W2080449286","https://openalex.org/W2091317847","https://openalex.org/W2143369735","https://openalex.org/W2157865424","https://openalex.org/W2164537308","https://openalex.org/W2342001136","https://openalex.org/W2414376778"],"related_works":["https://openalex.org/W1971084723","https://openalex.org/W224839684","https://openalex.org/W1862194997","https://openalex.org/W1966871277","https://openalex.org/W2143369735","https://openalex.org/W2060647366","https://openalex.org/W2172074742","https://openalex.org/W1948107809","https://openalex.org/W1974837721","https://openalex.org/W2164537308"],"abstract_inverted_index":{"1.":[0],"Pancreatic":[1],"islet":[2,95,124,129,143],"insulin":[3,110,147,174],"secretion":[4],"and":[5,25,39,45,57,76,109,114,146,161],"45Ca":[6,107,144],"uptake":[7,108,145],"showed":[8],"similar":[9],"responses":[10,67],"to":[11],"variation":[12],"in":[13,82,123,155,168],"the":[14,92,133,156,169],"extracellular":[15],"concentration":[16,56],"of":[17,41,54,68,91,104,135,159,173],"4-methyl-2-oxopentanoate":[18,55],"with":[19,102],"a":[20,26,30,50,59,119],"threshold":[21],"at":[22,29,62,88],"4":[23],"mM":[24,32],"maximal":[27,60],"response":[28,61],"25":[31,63],"concentration.":[33],"2.":[34],"Islet":[35],"respiration,":[36],"acetoacetate":[37],"production":[38],"rates":[40,134],"substrate":[42],"utilization,":[43],"oxidation":[44,137],"amination":[46],"all":[47],"changed":[48],"as":[49,166],"simple":[51],"hyperbolic":[52,81],"function":[53],"exhibited":[58],"mM.":[64],"3.":[65],"The":[66,94],"ATP":[69,130],"content,":[70],"[ATP]/[ADP]":[71],"ratio,":[72,97],"adenylate":[73],"energy":[74],"charge":[75],"[NADH]/[NAD+]":[77],"ratio":[78],"were":[79,85],"also":[80],"nature":[83],"but":[84,140],"maximally":[86],"elevated":[87],"lower":[89],"concentrations":[90],"secretagogue.":[93],"[NADPH]/[NADP+]":[96],"however,":[98],"was":[99],"tightly":[100],"correlated":[101],"parameters":[103],"metabolic":[105],"flux,":[106],"release.":[111,148],"4.":[112],"NH4+":[113],"menadione,":[115],"agents":[116],"that":[117,153],"promote":[118],"more":[120],"oxidized":[121],"state":[122,158],"NADP,":[125],"did":[126],"not":[127],"affect":[128],"content":[131],"or":[132,138],"[U-14C]4-methyl-2-oxopentanoate":[136],"amination,":[139],"markedly":[141],"inhibited":[142],"5.":[149],"It":[150],"is":[151],"proposed":[152],"changes":[154],"redox":[157],"NADP":[160],"Ca":[162],"transport":[163],"may":[164],"serve":[165],"mediators":[167],"stimulus-secretion":[170],"coupling":[171],"mechanism":[172],"release":[175],"induced":[176],"by":[177],"4-methyl-2-oxopentanoate.":[178]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
