{"id":"https://openalex.org/W76982471","doi":"https://doi.org/10.1096/fasebj.21.5.a559-a","title":"Modulation and reconfiguration of the pontomedullary respiratory network: A computational modeling study","display_name":"Modulation and reconfiguration of the pontomedullary respiratory network: A computational modeling study","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W76982471","doi":"https://doi.org/10.1096/fasebj.21.5.a559-a","mag":"76982471"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a559-a","doi":"https://doi.org/10.1096/fasebj.21.5.a559-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a559-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028370787","display_name":"Bruce G. Lindsey","orcid":"https://orcid.org/0000-0003-0546-7534","observed_orcids":["https://orcid.org/0000-0003-0546-7534"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B G Lindsey","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Ross","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112916948","display_name":"R. O'Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R O'Connor","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105109937","display_name":"Kendall F. Morris","orcid":"https://orcid.org/0000-0001-6582-1203","observed_orcids":["https://orcid.org/0000-0001-6582-1203"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K F Morris","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078980895","display_name":"Sarah C. Nuding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S C Nuding","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109170514","display_name":"Lauren S. Segers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L S Segers","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068519630","display_name":"Roger Shannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Shannon","raw_affiliation_strings":["Molec Pharm & Phys USF, MDC Tampa FL 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molec Pharm & Phys USF, MDC Tampa FL 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011262817","display_name":"Thomas E. Dick","orcid":"https://orcid.org/0000-0003-3287-8566","observed_orcids":["https://orcid.org/0000-0003-3287-8566"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T E Dick","raw_affiliation_strings":["Med & Neuro CWRU 10900 Euclid Ave Cleveland OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med & Neuro CWRU 10900 Euclid Ave Cleveland OH 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023134890","display_name":"Witali L. Dunin-Barkowski","orcid":"https://orcid.org/0000-0003-2716-7786","observed_orcids":["https://orcid.org/0000-0003-2716-7786"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"W L Dunin\u2010Barkowski","raw_affiliation_strings":["Info.Trans. Probl. Inst. Russ. Acad. Sci., Lab #12 Moscow Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Info.Trans. Probl. Inst. Russ. Acad. Sci., Lab #12 Moscow Russian Federation","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080911985","display_name":"John Orem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Orem","raw_affiliation_strings":["Phys Texas Tech Sch Med 4th&Indiana Lubbock TX 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phys Texas Tech Sch Med 4th&Indiana Lubbock TX 79430","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021747865","display_name":"Irene C Solomon","orcid":"https://orcid.org/0009-0007-2324-3856","observed_orcids":["https://orcid.org/0009-0007-2324-3856"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I C Solomon","raw_affiliation_strings":["Phys & Bio SUNY Stony Brook, T\u20106 Stony Brook NY 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phys & Bio SUNY Stony Brook, T\u20106 Stony Brook NY 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088027738","display_name":"Ilya A. Rybak","orcid":"https://orcid.org/0000-0003-3461-349X","observed_orcids":["https://orcid.org/0000-0003-3461-349X"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I A Rybak","raw_affiliation_strings":["Neurobio & Anat Drexel Univ. Coll of Med 2900 Queen Ln Phila. PA 19129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobio & Anat Drexel Univ. Coll of Med 2900 Queen Ln Phila. PA 19129","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1363,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44988399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventral-respiratory-column","display_name":"ventral respiratory column","score":0.9980000257492065},{"id":"https://openalex.org/keywords/raphe-nuclei","display_name":"raphe nuclei","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cough","display_name":"cough","score":0.7250000238418579},{"id":"https://openalex.org/keywords/expiratory-neurons","display_name":"expiratory neurons","score":0.7329999804496765},{"id":"https://openalex.org/keywords/network-reconfiguration","display_name":"network reconfiguration","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6750980615615845},{"id":"https://openalex.org/C2777615928","wikidata":"https://www.wikidata.org/wiki/Q26261774","display_name":"Raphe","level":5,"score":0.5257914066314697},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5145763754844666},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45472991466522217},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.41835737228393555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35335129499435425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3120177984237671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1552487313747406},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.1363174021244049},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0792146623134613},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a559-a","doi":"https://doi.org/10.1096/fasebj.21.5.a559-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a559-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976163772","https://openalex.org/W2133753342","https://openalex.org/W3175693138","https://openalex.org/W3176144274","https://openalex.org/W7095439778","https://openalex.org/W2287975274","https://openalex.org/W2076069865","https://openalex.org/W1992143213","https://openalex.org/W3176630175","https://openalex.org/W2120825033"],"abstract_inverted_index":{"In":[0],"previous":[1,93],"models":[2],"for":[3,152,182],"respiratory":[4,12,30,53,58,99,127,191],"motor":[5],"pattern":[6],"generation,":[7],"connectivity":[8],"of":[9,26,50,60,78,87,113,129,144,187],"the":[10,27,51,109],"pontine":[11],"group":[13],"(PRG)":[14],"has":[15],"been":[16],"largely":[17],"ad":[18],"hoc.":[19],"We":[20,155],"have":[21],"identified":[22],"interactions":[23],"among":[24,123],"neurons":[25,64,124],"PRG,":[28],"ventral":[29],"column":[31],"(VRC),":[32],"and":[33,40,44,62,70,85,184,193],"raphe":[34,63,79],"nuclei":[35],"using":[36],"multi\u2010array":[37],"recording":[38],"technology":[39],"spike":[41],"train":[42],"analysis,":[43],"incorporated":[45],"these":[46],"in":[47,94,108,135,175,190],"our":[48],"model":[49,56,110],"pontomedullary":[52],"network.":[54],"The":[55],"predicts":[57],"modulation":[59,77,112,128],"PRG":[61,165],"is":[65],"due":[66],"to":[67,172],"VRC":[68,88],"inputs":[69],"intrinsic":[71],"connectivity.":[72],"Simulations":[73],"show":[74],"that":[75],"baroreceptor":[76],"prolongs":[80],"expiration":[81],"through":[82],"parallel":[83],"excitation":[84],"disinhibition":[86],"decrementing":[89],"expiratory":[90],"neurons,":[91],"supporting":[92],"vivo":[95],"observations.":[96],"An":[97],"increased":[98],"rate,":[100],"as":[101],"during":[102,162],"REM":[103],"sleep,":[104],"can":[105],"be":[106],"reproduced":[107],"via":[111],"a":[114,136,149,158,180],"conditionally":[115],"bursting":[116],"I\u2010driver":[117],"population.":[118],"Respiratory":[119],"phase\u2010dependent":[120],"firing":[121,132,167],"synchrony":[122],"with":[125],"no":[126],"their":[130],"individual":[131],"rates":[133],"occurs":[134],"recurrent":[137],"inhibitory":[138],"circuit":[139],"receiving":[140],"an":[141],"efferent":[142],"copy":[143],"inspiratory":[145],"drive,":[146],"thus":[147],"providing":[148],"plausible":[150],"mechanism":[151],"earlier":[153],"results.":[154],"also":[156],"observe":[157],"specific":[159],"network":[160],"reconfiguration":[161],"simulated":[163],"cough;":[164],"neuron":[166],"rate":[168],"responses":[169],"are":[170],"similar":[171],"those":[173],"observed":[174],"vivo.":[176],"Our":[177],"work":[178],"provides":[179],"framework":[181],"theoretical":[183],"experimental":[185],"analysis":[186],"PRG\u2010VRC":[188],"loops":[189],"control":[192],"chemoreceptor":[194],"reflex":[195],"circuits.":[196],"Supported":[197],"by":[198],"grants":[199],"NS46062,":[200],"NS19814.":[201]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}