{"id":"https://openalex.org/W769700675","doi":null,"title":"Cancer cachexia: mediating factors and the effect of eicosapentaenoic acid dieting","display_name":"Cancer cachexia: mediating factors and the effect of eicosapentaenoic acid dieting","publication_year":2010,"publication_date":"2010-12-31","ids":{"openalex":"https://openalex.org/W769700675","mag":"769700675"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.937.1690","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.937.1690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.agro-b43d640e-83c0-4866-9e5b-cea2b250d9e3/c/fulltext553.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.jpccr.eu/pdf-71357-8589?filename=Cancer cachexia_.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ma\u0142gorzata Kowalczewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Kowalczewska","raw_affiliation_strings":["Department of Immunology, Nicolaus Copernicus University, Torun, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nicolaus Copernicus University, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012585382","display_name":"Sylwia Wrotek","orcid":"https://orcid.org/0000-0001-8744-7822","observed_orcids":["https://orcid.org/0000-0001-8744-7822"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Sylwia Wrotek","raw_affiliation_strings":["Department of Immunology, Nicolaus Copernicus University, Torun, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8744-7822","affiliations":[{"raw_affiliation_string":"Department of Immunology, Nicolaus Copernicus University, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091766315","display_name":"Tomasz J\u0119drzejewski","orcid":"https://orcid.org/0000-0001-8950-5643","observed_orcids":["https://orcid.org/0000-0001-8950-5643"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz J\u0119drzejewski","raw_affiliation_strings":["Department of Immunology, Nicolaus Copernicus University, Torun, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8950-5643","affiliations":[{"raw_affiliation_string":"Department of Immunology, Nicolaus Copernicus University, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003076386","display_name":"Wies\u0142aw Kozak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wies\u0142aw Kozak","raw_affiliation_strings":["Department of Immunology, Nicolaus Copernicus University, Torun, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nicolaus Copernicus University, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019271933"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"4","issue":"2","first_page":"108","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":1.0},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7710000276565552},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8209999799728394},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-host-interaction","display_name":"tumor-host interaction","score":0.7139999866485596},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/proteolysis-inducing-factor","display_name":"proteolysis-inducing factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.7889999747276306},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6790000200271606},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.859223484992981},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.8375858664512634},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.6777975559234619},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.655204176902771},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.6506468057632446},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6244827508926392},{"id":"https://openalex.org/C2781277698","wikidata":"https://www.wikidata.org/wiki/Q861974","display_name":"Dieting","level":4,"score":0.6082361936569214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5991702079772949},{"id":"https://openalex.org/C3020092424","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cancer cachexia","level":4,"score":0.5286239385604858},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5046626329421997},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5005300045013428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4887802302837372},{"id":"https://openalex.org/C2780723184","wikidata":"https://www.wikidata.org/wiki/Q6808975","display_name":"Megestrol acetate","level":3,"score":0.4688725769519806},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.292542040348053},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.28149300813674927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2535448670387268},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.247298002243042},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.1872638463973999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13319650292396545}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.937.1690","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.937.1690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.agro-b43d640e-83c0-4866-9e5b-cea2b250d9e3/c/fulltext553.pdf","raw_type":"text"},{"id":"mag:769700675","doi":null,"is_oa":true,"landing_page_url":"http://www.jpccr.eu/pdf-71357-8589?filename=Cancer cachexia_.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764897176","display_name":"Journal of Pre-Clinical and Clinical Research","issn_l":"1898-2395","issn":["1898-2395","1898-7516"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","poland-40"],"host_organization":"https://openalex.org/P4310317348","host_organization_name":"Institute of Rural Health","host_organization_lineage":["https://openalex.org/P4310317348"],"host_organization_lineage_names":["Institute of Rural Health"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pre-Clinical and Clinical Research","raw_type":null}],"best_oa_location":{"id":"mag:769700675","doi":null,"is_oa":true,"landing_page_url":"http://www.jpccr.eu/pdf-71357-8589?filename=Cancer cachexia_.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764897176","display_name":"Journal of Pre-Clinical and Clinical Research","issn_l":"1898-2395","issn":["1898-2395","1898-7516"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","poland-40"],"host_organization":"https://openalex.org/P4310317348","host_organization_name":"Institute of Rural Health","host_organization_lineage":["https://openalex.org/P4310317348"],"host_organization_lineage_names":["Institute of Rural Health"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pre-Clinical and Clinical Research","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W43648971","https://openalex.org/W96614748","https://openalex.org/W1517660847","https://openalex.org/W1979243593","https://openalex.org/W1981781126","https://openalex.org/W1982347136","https://openalex.org/W1984343804","https://openalex.org/W1991475114","https://openalex.org/W1998245074","https://openalex.org/W2004253639","https://openalex.org/W2014326660","https://openalex.org/W2035421972","https://openalex.org/W2037751427","https://openalex.org/W2037898183","https://openalex.org/W2039233900","https://openalex.org/W2042477580","https://openalex.org/W2046430126","https://openalex.org/W2047431121","https://openalex.org/W2051562734","https://openalex.org/W2058874539","https://openalex.org/W2065918344","https://openalex.org/W2072000048","https://openalex.org/W2080898783","https://openalex.org/W2082764531","https://openalex.org/W2088477747","https://openalex.org/W2090554250","https://openalex.org/W2096614115","https://openalex.org/W2099277089","https://openalex.org/W2105537858","https://openalex.org/W2112991763","https://openalex.org/W2126540916","https://openalex.org/W2129170868","https://openalex.org/W2146198074","https://openalex.org/W2151191545","https://openalex.org/W2156523912","https://openalex.org/W2160376635","https://openalex.org/W2271962043"],"related_works":["https://openalex.org/W7097354382","https://openalex.org/W2050676536","https://openalex.org/W2082300700","https://openalex.org/W2013787231","https://openalex.org/W1998564112","https://openalex.org/W1205975583","https://openalex.org/W2037898183","https://openalex.org/W1998245074","https://openalex.org/W1785961401","https://openalex.org/W2235837060"],"abstract_inverted_index":{"Abstract:\\t":[0],"Cancer":[1],"cachexia":[2,126],"is":[3],"an":[4,37],"involuntary":[5],"weight":[6],"loss":[7],"of":[8,13,19,40,48,67,79,90,99,124],"more":[9],"than":[10],"10":[11],"%":[12],"premorbid":[14],"weight,":[15],"caused":[16],"by":[17],"depletion":[18],"lipid":[20],"stores,":[21],"muscle":[22],"wasting,":[23],"anorexia":[24],"and":[25,46,96],"metabolic":[26],"alterations.":[27],"It":[28],"results":[29],"from":[30],"a":[31,64],"complex":[32],"tumour-host":[33],"interaction":[34],"associated":[35],"with":[36],"elevated":[38],"production":[39,89],"cytokines":[41],"(e.g.":[42,52],"TNF-\u03b1,":[43],"IL-1,":[44],"IL-6)":[45],"release":[47],"tumour-derived":[49],"catabolic":[50],"factors":[51],"lipid-mobilizing":[53],"factor,":[54],"protein-mobilizing":[55],"factor).":[56],"In":[57,104],"this":[58],"paper":[59],"we":[60],"discuss":[61],"data":[62,83],"suggesting":[63],"potential":[65],"role":[66],"\u03c9-3":[68],"fatty":[69],"acids,":[70],"such":[71],"as":[72],"eicosapentaenoic":[73],"acid":[74],"(EPA)":[75],"in":[76],"the":[77,93,100,122],"treatment":[78],"cancer":[80,125],"cachexia.":[81],"These":[82],"indicate":[84],"that":[85,118],"dieting":[86],"EPA":[87,119],"decreases":[88],"cytokines,":[91],"attenuates":[92],"lipolysis":[94],"process":[95],"reduces":[97],"activity":[98],"proteolysis-inducing":[101],"factor":[102],"(PIF).":[103],"contrast":[105],"to":[106],"other":[107],"therapeutic":[108],"agents,":[109],"which":[110],"only":[111],"improve":[112],"appetite,":[113],"it":[114],"has":[115],"been":[116],"shown":[117],"supplementation":[120],"prolonged":[121],"survival":[123],"patients.":[127]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
