{"id":"https://openalex.org/W769441934","doi":null,"title":"Sex Differences in Total and Specific Antioxidant Enzymes in Unirradiated and Irradiated Skin","display_name":"Sex Differences in Total and Specific Antioxidant Enzymes in Unirradiated and Irradiated Skin","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W769441934","mag":"769441934"},"language":"en","primary_location":{"id":"pmh:oai:kb.osu.edu:1811/32158","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/32158","pdf_url":"http://hdl.handle.net/1811/32158","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1811/32158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068341226","display_name":"Jessica Rosette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jessica Rosette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068341226"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8159999847412109},{"id":"https://openalex.org/keywords/uv-b-irradiation","display_name":"UVB irradiation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.715743899345398},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.6973966360092163},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6652835607528687},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.637142539024353},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.6015336513519287},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5881165862083435},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5573105812072754},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5531837940216064},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5068357586860657},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5023651123046875},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4512731432914734},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4439471662044525},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.430919885635376},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40958675742149353},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.40224581956863403},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3999102711677551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3969424366950989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3895834982395172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35769614577293396},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3245480954647064},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27887219190597534},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.22502222657203674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11350134015083313},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11317911744117737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10448676347732544},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kb.osu.edu:1811/32158","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/32158","pdf_url":"http://hdl.handle.net/1811/32158","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:769441934","doi":null,"is_oa":false,"landing_page_url":"https://kb.osu.edu/dspace/bitstream/handle/1811/32158/researchfinaldraft.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kb.osu.edu:1811/32158","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/32158","pdf_url":"http://hdl.handle.net/1811/32158","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W769441934.pdf","grobid_xml":"https://content.openalex.org/works/W769441934.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1525322545","https://openalex.org/W1973872210","https://openalex.org/W1987784120","https://openalex.org/W1999343644","https://openalex.org/W2001369026","https://openalex.org/W2001420924","https://openalex.org/W2001589466","https://openalex.org/W2012908941","https://openalex.org/W2019978470","https://openalex.org/W2059149560","https://openalex.org/W2065906579","https://openalex.org/W2082184305","https://openalex.org/W2083451381","https://openalex.org/W2100130506","https://openalex.org/W2102127185","https://openalex.org/W2113307947","https://openalex.org/W2147206627","https://openalex.org/W2168705167","https://openalex.org/W2408131856","https://openalex.org/W2467675610"],"related_works":["https://openalex.org/W2102127185","https://openalex.org/W2021092357","https://openalex.org/W14157273","https://openalex.org/W2088101697","https://openalex.org/W1999273878","https://openalex.org/W2582865222","https://openalex.org/W3094505585","https://openalex.org/W2462053669","https://openalex.org/W2340170885","https://openalex.org/W2166809965"],"abstract_inverted_index":{"Nonmelanoma":[0],"skin":[1,82,115,239,274,280,308,341,345,374],"cancers":[2],"have":[3,41,69,139],"been":[4,42],"reported":[5],"to":[6,44,55,90,108,138,159,170,209,222,322,333],"be":[7,320],"more":[8,57,149],"predominant":[9],"in":[10,25,34,51,80,93,105,113,186,218,226,237,243,257,272,278,292,306,339,342,376],"the":[11,15,32,81,110,122,160,166,172,176,181,190,279,307,310,334,352,370],"male":[12,91,135,238,273,340],"gender":[13,111,177,184,252],"with":[14],"incidence":[16,33],"of":[17,83,132,145,165,281,309,373],"basal":[18],"cell":[19,23],"carcinoma":[20,24],"and":[21,29,49,67,77,118,154,183,189,192,202,240,265,346,357],"squamous":[22],"males":[26,293,317],"being":[27],"two":[28],"three":[30],"times":[31],"females":[35,331],"respectively.":[36],"Until":[37],"recently":[38],"these":[39,313],"differences":[40,112,185,256,305],"attributed":[43],"lifestyle":[45],"variations":[46],"amongst":[47],"men":[48,53],"women":[50],"which":[52],"seem":[54],"spend":[56],"time":[58],"outside":[59],"while":[60,287],"using":[61],"less":[62,144],"sun":[63],"protection.":[64],"Our":[65],"laboratory":[66],"others":[68],"established":[70],"a":[71,94,206,223,365],"correlation":[72],"between":[73],"UVB-induced":[74,114,187],"cutaneous":[75,150,215,325],"inflammation":[76,188,216],"tumor":[78,142],"susceptibility":[79],"female":[84,161],"mice.":[85,162],"These":[86,297],"findings":[87],"were":[88,249,268],"compared":[89,158],"mice":[92,136],"recent":[95],"study":[96,168],"done":[97],"by":[98,179],"Thomas-Ahner":[99,126],"et.":[100],"al.":[101],"(Cancer":[102],"Research":[103],"2007)":[104],"our":[106,355,358],"lab":[107],"evaluate":[109],"carcinogenesis,":[116],"inflammation,":[117],"DNA":[119,152,326],"damage.":[120],"Using":[121],"Skh-1":[123],"mouse":[124],"model,":[125],"found":[127,212,338],"that":[128,213,231,300,316,362],"under":[129],"equal":[130],"doses":[131],"UVB":[133],"exposure,":[134],"tend":[137],"an":[140,146],"accelerated":[141],"progression,":[143],"inflammatory":[147],"response,":[148],"oxidative":[151],"damage,":[153],"lower":[155,234,269,335],"antioxidant":[156,194,336],"levels":[157,372],"The":[163],"goal":[164],"current":[167,356],"was":[169,233],"continue":[171],"ongoing":[173],"investigation":[174],"into":[175],"disparities":[178],"examining":[180],"temporal":[182],"total":[191],"specific":[193,303],"enzymes,":[195],"including":[196],"catalase,":[197],"glutathione":[198,200,203,261,263,266,288],"peroxidase,":[199],"s-transferase,":[201],"reductase,":[204],"after":[205,246,284,294,347],"single":[207],"exposure":[208,286],"UVB.":[210],"We":[211,228],"UV-induced":[214],"increased":[217],"both":[219,244,282,343],"genders":[220,245,283],"but":[221],"greater":[224],"extent":[225],"females.":[227],"also":[229],"determined":[230],"catalase":[232],"at":[235,270],"baseline":[236,271],"decreased":[241,277,291],"equally":[242],"UV;":[247],"there":[248,301,363],"no":[250],"significant":[251],"or":[253,260],"UV":[254,285,295,348],"mediated":[255],"superoxide":[258],"dismutase":[259],"reductase;":[262],"peroxidase":[264,289],"s-transferase":[267,276],"and\\n2\\nglutathione":[275],"only":[290],"exposure.":[296,349],"results":[298,353],"demonstrate":[299],"are":[302],"inherent":[304],"genders.":[311],"Furthermore":[312],"studies":[314,360],"suggest":[315,361],"may":[318],"not":[319],"able":[321],"ward":[323],"off":[324],"damage":[327],"as":[328,330],"well":[329],"due":[332],"activities":[337],"unirradiated":[344],"Taken":[350],"together,":[351],"from":[354],"published":[359],"is":[364],"possible":[366],"biological":[367],"explanation":[368],"for":[369],"higher":[371],"cancer":[375],"men.":[377]},"counts_by_year":[],"updated_date":"2026-09-02T18:50:13.731487","created_date":"2016-06-24T00:00:00"}