{"id":"https://openalex.org/W76847337","doi":null,"title":"Comparison of DNA ploidy, histologic, and immunohistochemical findings with clinical outcome in inflammatory myofibroblastic tumors.","display_name":"Comparison of DNA ploidy, histologic, and immunohistochemical findings with clinical outcome in inflammatory myofibroblastic tumors.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W76847337","mag":"76847337","pmid":"https://pubmed.ncbi.nlm.nih.gov/10102613"},"language":"en","primary_location":{"id":"pmid:10102613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10102613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026809155","display_name":"Jerry W. Hussong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324574813","display_name":"Primary Children's Hospital","ror":"https://ror.org/053hkmn05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I1324574813"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J W Hussong","raw_affiliation_strings":["Department of Pathology, University of Utah Health Sciences Center and Primary Children's Medical Center, Salt Lake City 84113-1100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah Health Sciences Center and Primary Children's Medical Center, Salt Lake City 84113-1100, USA","institution_ids":["https://openalex.org/I1324574813","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Brown","raw_affiliation_strings":["University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110146491","display_name":"Sherrie L. Perkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Perkins","raw_affiliation_strings":["CLINICAL PATHOLOGY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLINICAL PATHOLOGY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049058632","display_name":"Louis P. Dehner","orcid":"https://orcid.org/0000-0002-2007-5638","observed_orcids":["https://orcid.org/0000-0002-2007-5638"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L P Dehner","raw_affiliation_strings":["Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108701736","display_name":"Cheryl M. Coffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324574813","display_name":"Primary Children's Hospital","ror":"https://ror.org/053hkmn05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I1324574813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Coffin","raw_affiliation_strings":["Primary Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Primary Children's Medical Center","institution_ids":["https://openalex.org/I1324574813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7423,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.92978499,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"3","first_page":"279","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11991","display_name":"Soft tissue tumor case studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-myofibroblastic-tumor","display_name":"inflammatory myofibroblastic tumor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9660000205039978},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.703000009059906},{"id":"https://openalex.org/keywords/cytological-atypia","display_name":"cytologic atypia","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/soft-tissue-tumors","display_name":"soft tissue tumor","score":0.6240000128746033},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7821957468986511},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.748589277267456},{"id":"https://openalex.org/C2781283455","wikidata":"https://www.wikidata.org/wiki/Q1960558","display_name":"Atypia","level":2,"score":0.7307494878768921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47363439202308655},{"id":"https://openalex.org/C2781289014","wikidata":"https://www.wikidata.org/wiki/Q7068032","display_name":"Nuclear atypia","level":3,"score":0.43341463804244995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3488931655883789}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006104","descriptor_name":"Granuloma, Plasma Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006104","descriptor_name":"Granuloma, Plasma Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006104","descriptor_name":"Granuloma, Plasma Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006104","descriptor_name":"Granuloma, Plasma Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10102613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10102613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Comparative Study"},{"id":"mag:76847337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10102613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053588842","https://openalex.org/W2078541419","https://openalex.org/W1998941489","https://openalex.org/W2378600610","https://openalex.org/W2376255916","https://openalex.org/W2152738964","https://openalex.org/W2148274228","https://openalex.org/W2177757053","https://openalex.org/W130429908","https://openalex.org/W1489741694"],"abstract_inverted_index":{"Inflammatory":[0],"myofibroblastic":[1],"tumors":[2,181],"(IMTs)":[3],"are":[4],"uncommon":[5],"spindle":[6],"cell":[7],"proliferations":[8],"that":[9,62,271],"occur":[10],"in":[11,53,55,127,145,165,208],"the":[12,110,130,151,166,175,180,212,218],"viscera":[13],"and":[14,19,31,45,50,97,101,118,137,148,157,184,198,260],"soft":[15],"tissue":[16],"of":[17,28,47,109,129,150,168,179,195,200,211,226,241,249,254],"children":[18],"young":[20],"adults.":[21],"Their":[22],"biologic":[23],"potential":[24],"is":[25],"indeterminate:":[26],"25%":[27],"IMTs":[29,54,73,111,152,222,270],"recur,":[30,114],"rare":[32],"examples":[33],"undergo":[34,273],"malignant":[35],"transformation":[36],"(MT).":[37],"This":[38],"study":[39],"investigates":[40],"histologic":[41],"features,":[42],"DNA":[43,91,261],"ploidy,":[44],"expression":[46,103,205,240,259],"apoptotic":[48],"regulatory":[49],"oncogenic":[51],"proteins":[52],"an":[56],"attempt":[57],"to":[58,268],"identify":[59,269],"those":[60],"deviances":[61],"might":[63,265,272],"correlate":[64],"with":[65,135,139,155,158,214,282],"aggressive":[66,279],"behavior":[67],"or":[68,171,236,243,275],"MT.":[69,122,140,203,229],"Twenty-four":[70],"formalin-fixed,":[71],"paraffin-embedded":[72],"for":[74,82,192,233,247],"which":[75,196,201,227],"clinical":[76,250,280],"outcome":[77,176],"was":[78,125,162,206],"known":[79],"were":[80,143,190,223,245],"evaluated":[81],"cellularity,":[83,169,234],"cytologic":[84],"atypia,":[85,255],"mitoses,":[86,170],"ganglion-like":[87,256],"cells,":[88,257],"inflammatory":[89,172,237],"infiltrate,":[90],"ploidy":[92,262],"by":[93,104],"flow":[94],"cytometric":[95],"examination,":[96],"bax,":[98,183],"bcl-2,":[99],"p53,":[100,193],"c-myc":[102,244],"immunohistochemical":[105],"analysis.":[106],"Sixteen":[107],"(67%)":[108],"did":[112],"not":[113],"6":[115],"(25%)":[116],"recurred,":[117],"2":[119],"(8%)":[120,189],"underwent":[121,202,228],"Cellular":[123],"atypia":[124],"observed":[126,207],"69%":[128],"cases":[131],"without":[132,153],"recurrence,":[133,136,154,156],"100%":[134,138,149],"Ganglion-like":[141],"cells":[142],"present":[144],"56,":[146],"100,":[147],"MT,":[159],"respectively.":[160],"There":[161],"no":[163,215],"difference":[164,216],"degree":[167],"infiltrate":[173,238],"among":[174,217],"groups.":[177,220],"All":[178],"expressed":[182,186],"none":[185],"c-myc.":[187],"Two":[188,221],"immunoreactive":[191],"one":[194,199,225],"recurred":[197],"bcl-2":[204],"9":[209],"(37%)":[210],"IMTs,":[213],"three":[219],"aneuploid,":[224],"Neither":[230],"morphologic":[231],"evaluation":[232],"mitosis,":[235],"nor":[239],"bax":[242],"useful":[246,267],"prediction":[248],"outcome.":[251],"The":[252],"combination":[253],"p53":[258],"analysis,":[263],"however,":[264],"be":[266],"MT":[274],"pursue":[276],"a":[277],"more":[278],"course":[281],"recurrences.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}