{"id":"https://openalex.org/W7683402","doi":null,"title":"Acute chest syndrome in children with sickle cell disease. A retrospective analysis of 100 hospitalized cases.","display_name":"Acute chest syndrome in children with sickle cell disease. A retrospective analysis of 100 hospitalized cases.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W7683402","mag":"7683402","pmid":"https://pubmed.ncbi.nlm.nih.gov/3740365"},"language":"en","primary_location":{"id":"pmid:3740365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3740365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pediatric hematology/oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024660255","display_name":"Robert Hunt Sprinkle","orcid":"https://orcid.org/0000-0001-6961-1211","observed_orcids":["https://orcid.org/0000-0001-6961-1211"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R H Sprinkle","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Cole","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Smith","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114103320","display_name":"G. R. Buchanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Buchanan","raw_affiliation_strings":["Int Med - Chairman's Office"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Int Med - Chairman's Office","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4497,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.78205128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"8","issue":"2","first_page":"105","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pulmonary-infiltrates","display_name":"pulmonary infiltrates","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pleural-effusion","display_name":"pleural effusion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.8450000286102295},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7099999785423279},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.8960000276565552},{"id":"https://openalex.org/keywords/haemophilus-influenzae-type-b","display_name":"Haemophilus influenzae type b","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pneumococcal-vaccine","display_name":"pneumococcal vaccine","score":0.8709999918937683},{"id":"https://openalex.org/keywords/penicillin-prophylaxis","display_name":"penicillin prophylaxis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9619417190551758},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.7806714773178101},{"id":"https://openalex.org/C2778704086","wikidata":"https://www.wikidata.org/wiki/Q693058","display_name":"Chest pain","level":2,"score":0.5660285949707031},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.4974866211414337},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4710797071456909},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4688243567943573},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.466442346572876},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4224557876586914},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.3607553243637085},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.18661099672317505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3740365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3740365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pediatric hematology/oncology","raw_type":"Journal Article"},{"id":"mag:7683402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3740365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1908535950","https://openalex.org/W1968206565","https://openalex.org/W1974457734","https://openalex.org/W1974705948","https://openalex.org/W1982324672","https://openalex.org/W1987781967","https://openalex.org/W1995337166","https://openalex.org/W1997044455","https://openalex.org/W1998832970","https://openalex.org/W2006875910","https://openalex.org/W2009505473","https://openalex.org/W2013714882","https://openalex.org/W2020184342","https://openalex.org/W2031803913","https://openalex.org/W2032485080","https://openalex.org/W2033296841","https://openalex.org/W2034285541","https://openalex.org/W2054956674","https://openalex.org/W2055882351","https://openalex.org/W2057870229","https://openalex.org/W2058630627","https://openalex.org/W2060608708","https://openalex.org/W2060910799","https://openalex.org/W2062520945","https://openalex.org/W2063936869","https://openalex.org/W2063940371","https://openalex.org/W2068290015","https://openalex.org/W2076893174","https://openalex.org/W2081992620","https://openalex.org/W2084673339","https://openalex.org/W2087673992","https://openalex.org/W2087756960","https://openalex.org/W2088978582","https://openalex.org/W2089125214","https://openalex.org/W2089530533","https://openalex.org/W2090135185","https://openalex.org/W2095476463","https://openalex.org/W2100157447","https://openalex.org/W2132922652","https://openalex.org/W2275819937","https://openalex.org/W2416389894","https://openalex.org/W2886049213","https://openalex.org/W4300850161","https://openalex.org/W4406968704","https://openalex.org/W6640330303","https://openalex.org/W6692694891"],"related_works":["https://openalex.org/W4249517110","https://openalex.org/W7214192670","https://openalex.org/W2087932371","https://openalex.org/W2184813301","https://openalex.org/W2070520701","https://openalex.org/W2024063751","https://openalex.org/W7160697946","https://openalex.org/W2027259967","https://openalex.org/W2198635490","https://openalex.org/W2256861248"],"abstract_inverted_index":{"We":[0,205],"reviewed":[1],"the":[2,9,33,39,208],"clinical":[3],"features":[4],"of":[5,8,22,52,62,71,103,115,158,193],"100":[6,104],"cases":[7,126,139,182],"sickle":[10,209],"cell":[11,210],"chest":[12,211],"syndrome":[13,55,212],"in":[14,32,38,50,60,69,101,113,123,127,136,140,180,184,201],"57":[15,160],"pediatric":[16],"patients":[17,72,91,161,170],"hospitalized":[18],"with":[19,221,230],"radiographic":[20],"findings":[21],"pulmonary":[23,217],"or":[24,42,110],"pleural":[25],"disease.":[26],"Pulmonary":[27],"infiltration":[28],"was":[29,56,65,107,120,178,199],"more":[30,81],"common":[31],"lower":[34],"lobes":[35,44],"(86%)":[36],"than":[37,87,95,148],"upper":[40],"(25%)":[41],"middle":[43],"(22%).":[45],"Pleural":[46],"effusions":[47],"were":[48,80,88,130,143],"present":[49],"38%":[51],"cases.":[53,105,116],"Chest":[54],"recognized":[57,66,78,90],"on":[58,84,173],"presentation":[59],"79%":[61],"cases,":[63],"but":[64,97,132,227],"only":[67,133,185],"later":[68],"21%":[70],"admitted":[73],"for":[74],"other":[75],"indications.":[76],"Patients":[77],"initially":[79],"often":[82],"febrile":[83,216],"admission":[85],"(68%)":[86],"subsequently":[89],"(33%)":[92],"(p":[93,146],"less":[94,147],"0.01),":[96],"fever":[98],"eventually":[99],"occurred":[100],"99":[102],"Pain":[106],"an":[108,214],"antecedent":[109],"coincident":[111],"problem":[112],"67%":[114],"Median":[117],"hospital":[118],"stay":[119],"7":[121],"days":[122,135],"those":[124,137],"58":[125],"which":[128,141],"narcotics":[129,142],"given,":[131],"4":[134],"42":[138],"not":[144],"administered":[145,155],"0.001).":[149],"Polyvalent":[150],"pneumococcal":[151],"vaccine":[152],"had":[153,171],"been":[154,172],"to":[156],"44":[157],"our":[159],"at":[162],"some":[163],"time":[164],"before":[165],"their":[166],"hospitalizations,":[167],"and":[168,183],"18":[169],"oral":[174],"penicillin":[175],"prophylaxis.":[176],"Blood":[177],"cultured":[179],"93":[181],"two":[186,202],"instances":[187],"grew":[188],"Streptococcus":[189],"pneumoniae.":[190],"Serologic":[191],"evidence":[192],"Hemophilus":[194],"influenzae":[195],"type":[196],"b":[197],"infection":[198],"found":[200],"additional":[203],"patients.":[204],"conclude":[206],"that":[207],"is":[213],"acute":[215],"disease":[218],"frequently":[219],"associated":[220,229],"pain":[222],"and/or":[223],"narcotic":[224],"analgesic":[225],"therapy":[226],"infrequently":[228],"proven":[231],"bacterial":[232],"infection.":[233]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}