{"id":"https://openalex.org/W76773376","doi":null,"title":"Protease Activity in Mesenteric Lymph Following Splanchnic Arterial Occlusion","display_name":"Protease Activity in Mesenteric Lymph Following Splanchnic Arterial Occlusion","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W76773376","mag":"76773376"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt46v780s1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/46v780s1","pdf_url":"https://escholarship.org/uc/item/46v780s1","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/46v780s1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael Richter","orcid":"https://orcid.org/0000-0002-2702-1237","observed_orcids":["https://orcid.org/0000-0002-2702-1237"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Richter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2702-1237","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.20180000364780426,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenteric-lymph","display_name":"mesenteric lymph","score":0.9639999866485596},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.8339999914169312},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.8479999899864197},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.996999979019165},{"id":"https://openalex.org/keywords/chymotrypsin","display_name":"chymotrypsin","score":1.0},{"id":"https://openalex.org/keywords/gut-ischemia-reperfusion","display_name":"gut ischemia/reperfusion","score":0.8029999732971191},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7139999866485596},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.7581290602684021},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6555920839309692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5792523622512817},{"id":"https://openalex.org/C2775849017","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic","level":3,"score":0.5182080864906311},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5045491456985474},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5011210441589355},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.42400598526000977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35235780477523804},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.26789700984954834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24126464128494263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11087822914123535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07371172308921814}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt46v780s1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/46v780s1","pdf_url":"https://escholarship.org/uc/item/46v780s1","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:76773376","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt46v780s1/qt46v780s1.pdf?t=ml375c","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt46v780s1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/46v780s1","pdf_url":"https://escholarship.org/uc/item/46v780s1","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W76773376.pdf","grobid_xml":"https://content.openalex.org/works/W76773376.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1636391291","https://openalex.org/W1900765734","https://openalex.org/W1965759325","https://openalex.org/W1967859572","https://openalex.org/W1973689970","https://openalex.org/W1976633327","https://openalex.org/W1987539592","https://openalex.org/W2002661425","https://openalex.org/W2007125285","https://openalex.org/W2008580253","https://openalex.org/W2012730541","https://openalex.org/W2012951310","https://openalex.org/W2016706472","https://openalex.org/W2018400133","https://openalex.org/W2020376230","https://openalex.org/W2020634202","https://openalex.org/W2026335028","https://openalex.org/W2028898179","https://openalex.org/W2031602088","https://openalex.org/W2064137749","https://openalex.org/W2064223953","https://openalex.org/W2070119435","https://openalex.org/W2081895687","https://openalex.org/W2086867902","https://openalex.org/W2090058869","https://openalex.org/W2112391531","https://openalex.org/W2115613435","https://openalex.org/W2126675634","https://openalex.org/W2128877620","https://openalex.org/W2163419440","https://openalex.org/W2168394276"],"related_works":["https://openalex.org/W2100035257","https://openalex.org/W2048953996","https://openalex.org/W2057201357","https://openalex.org/W2315386082","https://openalex.org/W2112391531","https://openalex.org/W2011356591","https://openalex.org/W2012951310","https://openalex.org/W1994663646","https://openalex.org/W642895825","https://openalex.org/W2140838922"],"abstract_inverted_index":{"The":[0,85],"lymphatics":[1],"play":[2],"a":[3,24,114,180,232],"key":[4],"role":[5],"in":[6,28,38,101,174,213,238,269],"the":[7,17,39,42,45,65,71,80,93,109,167,175,214,217,227,239,259,263,270],"pathogenesis":[8],"of":[9,19,68,87,97,134,146,219,235],"multiple":[10],"organ":[11,21,81],"failure":[12],"following":[13,244,273],"circulatory":[14],"shock.":[15,139,274],"Understanding":[16],"cause":[18],"this":[20,75,88],"dysfunction":[22],"is":[23],"fundamentally":[25],"unsolved":[26],"problem":[27],"medicine.":[29],"Current":[30],"results":[31,250],"show":[32],"that":[33,242,252,265],"biologically":[34],"active":[35],"molecules":[36],"produced":[37],"gut":[40,245],"enter":[41],"circulation":[43],"via":[44],"mesenteric":[46,69,127,240],"lymph":[47,128,135,160,176,241],"duct,":[48],"and":[49,56,78,95,111,131,192,210,216,247],"induce":[50],"neutrophil":[51],"activation,":[52],"increased":[53],"vascular":[54],"permeability,":[55],"acute":[57],"lung":[58],"injury.":[59],"Despite":[60],"several":[61],"attempts":[62],"to":[63,91,123,200],"determine":[64],"protein":[66],"composition":[67],"lymph,":[70,103,215],"factors":[72],"responsible":[73],"for":[74,163,188],"biological":[76],"activity":[77,96,173,191,212,237],"specifically":[79],"damage":[82],"are":[83,113,267],"unknown.":[84],"aim":[86],"study":[89],"was":[90,161,177,221],"investigate":[92],"level":[94,234],"pancreatic":[98,201],"digestive":[99,202,255],"proteases":[100,203],"post-shock":[102],"which":[104,112],"could":[105],"be":[106],"derived":[107],"from":[108,258],"intestine":[110],"potentially":[115],"damaging":[116],"mediator.":[117],"Male":[118],"Wistar":[119],"rats":[120],"were":[121],"subjected":[122],"laparotomy,":[124],"followed":[125,150],"by":[126,151,276],"duct":[129],"cannulation":[130],"one":[132,144],"hour":[133,145],"fluid":[136],"collection":[137],"before":[138],"Five":[140],"animals":[141,156],"then":[142],"underwent":[143],"splanchnic":[147,260],"arterial":[148],"occlusion":[149],"reperfusion,":[152],"while":[153],"sham":[154],"shock":[155,254],"remained":[157],"perfused.":[158],"Post-shock":[159],"collected":[162],"three":[164],"hours,":[165],"with":[166],"samples":[168],"aliquoted":[169],"every":[170],"hour.":[171],"Protease":[172],"analyzed":[178],"using":[179,223],"fluorescently":[181,195],"quenched":[182,196],"casein":[183],"substrate":[184],"as":[185],"an":[186],"indicator":[187],"general":[189],"protease":[190,236,256],"separately":[193],"charge-changing":[194],"peptide":[197],"substrates":[198],"specific":[199],"(trypsin,":[204],"chymotrypsin).":[205],"These":[206,249],"measurements":[207],"showed":[208],"trypsin":[209,220],"chymotrypsin":[211],"presence":[218],"confirmed":[222],"Western":[224],"analysis.":[225],"Over":[226],"time":[228],"course":[229],"we":[230],"see":[231],"base":[233],"increases":[243],"ischemia":[246],"reperfusion.":[248],"indicate":[251],"during":[253],"escape":[257],"bed,":[261],"raising":[262],"possibility":[264],"they":[266],"involved":[268],"systemic":[271],"injury":[272],"Supported":[275],"NIH":[277],"grant":[278],"GM-8507":[279]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}