{"id":"https://openalex.org/W76734072","doi":null,"title":"Characteristics of the protease activity in synovial fluid from patients with rheumatoid arthritis and osteoarthritis.","display_name":"Characteristics of the protease activity in synovial fluid from patients with rheumatoid arthritis and osteoarthritis.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W76734072","mag":"76734072","pmid":"https://pubmed.ncbi.nlm.nih.gov/10342041"},"language":"en","primary_location":{"id":"pmid:10342041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10342041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103026001","display_name":"Shunji Nakano","orcid":"https://orcid.org/0000-0003-4909-1137","observed_orcids":["https://orcid.org/0000-0003-4909-1137"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Nakano","raw_affiliation_strings":["Department of Orthopedic Surgery, School of Medicine, University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, School of Medicine, University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113994684","display_name":"T Ikata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ikata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063691835","display_name":"Izumi Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Kinoshita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085436918","display_name":"J Kanematsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kanematsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113456200","display_name":"S Yasuoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yasuoka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6237,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.64606826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"2","first_page":"161","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.4106000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9520000219345093},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.7689999938011169},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.6629999876022339},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fluorogenic-substrates","display_name":"fluorogenic substrates","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.8399776220321655},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.82487952709198},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.7990297079086304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7773656845092773},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6433911919593811},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6352882981300354},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.6141940355300903},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6129501461982727},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5670021772384644},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.4982779026031494},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.4910275936126709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48194408416748047},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.4816681146621704},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.47291287779808044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4378890097141266},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.4343961477279663},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2692779302597046},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2126687467098236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18617624044418335},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1538066864013672},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13723498582839966},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.05531352758407593},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.049020230770111084},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10342041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10342041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:76734072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10342041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1997932488","https://openalex.org/W2151447268","https://openalex.org/W2413314876","https://openalex.org/W2091385850","https://openalex.org/W6888906845","https://openalex.org/W2417681768","https://openalex.org/W2133802288","https://openalex.org/W2330728799","https://openalex.org/W2171885956","https://openalex.org/W2883868146"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"clarify":[2],"which":[3,56],"proteases":[4,25],"are":[5],"specifically":[6],"activated":[7],"in":[8,39,83,95,103,107,110,127,130,150,173,183,194,197,202,251],"the":[9,23,27,76,81,133,147,151,170,188,221,237,245,248,257],"lesions":[10],"of":[11,22,26,33,90,117,135,146,154,187,223,228,236,247,256],"rheumatoid":[12],"arthritis":[13],"(RA)":[14],"and":[15,29,32,35,46,86,97,121,137,210,213],"osteoarthritis":[16],"(OA).":[17],"METHODS:":[18],"The":[19,63,88,115],"activity":[20,79,92,120,149,160,166],"levels":[21,116,134],"serine":[24],"coagulation":[28,189,249],"fibrinolytic":[30,258],"systems,":[31],"elastase":[34],"collagenase":[36],"as":[37],"controls,":[38],"synovial":[40,152,238],"fluid":[41,153,239],"from":[42],"27":[43],"RA":[44,85,96,108,128,155,174,195,203,224],"patients":[45,49,156],"28":[47],"OA":[48,111],"were":[50,93,102,123,139],"measured":[51,71],"using":[52],"fluorogenic":[53],"synthetic":[54],"substrates":[55],"had":[57],"methylcoumarylamide":[58],"(MCA)":[59],"at":[60],"their":[61,100],"COOH-termini.":[62],"thrombin-antithrombin":[64],"III":[65],"complex":[66],"(TAT)":[67],"content":[68],"was":[69,80,161,191],"also":[70,232],"by":[72],"ELISA.":[73],"RESULTS:":[74],"Among":[75],"proteases,":[77],"thrombin-like":[78,119,148],"highest":[82],"both":[84,118],"OA.":[87,184,229],"profiles":[89],"protease":[91],"similar":[94],"OA,":[98,131,198],"but":[99,181,253],"activities":[101],"general":[104],"significantly":[105],"higher":[106,126],"than":[109,129,196,225],"(p":[112],"<":[113,179],"0.01).":[114],"TAT":[122,171],"about":[124,141],"7.5-fold":[125],"while":[132],"CRP":[136],"fibrinogen":[138],"only":[140],"2-fold":[142],"higher.":[143],"Biochemical":[144],"characterization":[145],"showed":[157],"that":[158,201,214,227,234,255],"this":[159],"due":[162],"to":[163,220,226,243],"thrombin.":[164],"Thrombin-like":[165],"positively":[167],"correlated":[168],"with":[169],"concentration":[172],"(r":[175],"=":[176],"0.750,":[177],"p":[178],"0.0001),":[180],"not":[182,254],"CONCLUSION:":[185],"Activation":[186],"system":[190,250],"more":[192,217],"marked":[193],"strongly":[199],"suggesting":[200],"there":[204],"is":[205,216],"an":[206],"imbalance":[207],"between":[208],"thrombin":[209,215],"its":[211],"inhibitors,":[212],"closely":[218],"linked":[219],"pathogenesis":[222],"Our":[230],"results":[231],"show":[233],"analysis":[235],"may":[240],"be":[241],"useful":[242],"estimate":[244],"activation":[246],"RA,":[252],"system.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}