{"id":"https://openalex.org/W76722401","doi":"https://doi.org/10.3760/cma.j.issn.0376-2491.2011.28.014","title":"[Regulating action of iron regulatory protein-2 in iron metabolism of lung cancer].","display_name":"[Regulating action of iron regulatory protein-2 in iron metabolism of lung cancer].","publication_year":2011,"publication_date":"2011-07-26","ids":{"openalex":"https://openalex.org/W76722401","doi":"https://doi.org/10.3760/cma.j.issn.0376-2491.2011.28.014","mag":"76722401","pmid":"https://pubmed.ncbi.nlm.nih.gov/22093897"},"language":"zh","primary_location":{"id":"pmid:22093897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22093897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053702872","display_name":"Zhe Cheng","orcid":"https://orcid.org/0000-0002-0894-2444","observed_orcids":["https://orcid.org/0000-0002-0894-2444","https://orcid.org/0000-0002-4847-3443"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Cheng","raw_affiliation_strings":["Department of Respiratory Medicine, Zhengzhou University, Zhengzhou, China. chengzhehi@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Zhengzhou University, Zhengzhou, China. chengzhehi@126.com","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376619","display_name":"Yufeng Liu","orcid":"https://orcid.org/0000-0002-5334-7759","observed_orcids":["https://orcid.org/0000-0002-5334-7759"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-feng Liu","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113456196","display_name":"Yong-na Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-na Song","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103090788","display_name":"Lingling Dai","orcid":"https://orcid.org/0000-0003-1379-2038","observed_orcids":["https://orcid.org/0000-0003-1379-2038"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-ling Dai","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102007921","display_name":"Yan Kang","orcid":"https://orcid.org/0000-0002-0967-7849","observed_orcids":["https://orcid.org/0000-0002-0967-7849"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Kang","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043226120","display_name":"Jie Lai Xia","orcid":"https://orcid.org/0000-0003-4574-9376","observed_orcids":["https://orcid.org/0000-0003-4574-9376"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Xia","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031646634","display_name":"Jiming Si","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-ming Si","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041836364","display_name":"Chunyan Chen","orcid":"https://orcid.org/0000-0001-9220-4569","observed_orcids":["https://orcid.org/0000-0001-9220-4569"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-yan Chen","raw_affiliation_strings":["Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2085,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55773613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"91","issue":"28","first_page":"1992","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irp2","display_name":"IRP2","score":0.9670000076293945},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/transferrin","display_name":"transferrin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8259999752044678},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6589999794960022},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7917886972427368},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7314315438270569},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.6968799233436584},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.6100281476974487},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.6090580821037292},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5934749245643616},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5773122310638428},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4905533194541931},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.46699467301368713},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4340222477912903},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4277960956096649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39996474981307983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2708953619003296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2138303518295288}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020319","descriptor_name":"Oligodeoxyribonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035942","descriptor_name":"Iron Regulatory Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035942","descriptor_name":"Iron Regulatory Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22093897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22093897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"Journal Article"},{"id":"mag:76722401","doi":"https://doi.org/10.3760/cma.j.issn.0376-2491.2011.28.014","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22093897/","pdf_url":null,"source":{"id":"https://openalex.org/S2751117172","display_name":"Zhonghua yixue zazhi","issn_l":"0376-2491","issn":["0376-2491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2319929797","https://openalex.org/W2272149278","https://openalex.org/W4388410579","https://openalex.org/W2350345300","https://openalex.org/W2013000450","https://openalex.org/W2025403494","https://openalex.org/W2049299765","https://openalex.org/W2063641389","https://openalex.org/W939139575","https://openalex.org/W1213244038"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"discuss":[2],"the":[3,12,46,52,71,94,113,119,128,142,153,171,176,185,215,223,232,237,245,257,270,276],"regulating":[4,275],"mechanism":[5],"of":[6,15,76,97,116,138,175,184,214,222,236,244,259,272],"iron":[7,13,77,277],"regulatory":[8],"protein-2":[9],"(IRP2)":[10],"in":[11,118,127,141,152,201,263],"metabolism":[14],"lung":[16,264],"cancer.":[17],"METHODS:":[18],"The":[19,136,193,210],"cultured":[20],"A549":[21,266],"cells":[22,267],"were":[23,67],"divided":[24],"into":[25],"3":[26],"groups:":[27],"liposome":[28,53,129,154,186,224,246],"group":[29,36,42,121,144,178,217,239],"(including":[30],"liposomes":[31],"20":[32],"mg/L),":[33],"random":[34],"oligonucleotide":[35,41],"(SCODN":[37],"group)":[38],"and":[39,54,64,73,84,130,158,187,225,247,261,274],"antisense":[40],"(ASODN":[43],"group).":[44],"And":[45,231],"liposome-mediated":[47],"transfection":[48],"was":[49,122,148,179,197,218,240],"employed":[50],"with":[51],"SCODN":[55,131,159,188,226,248],"groups":[56,106,132,160,189,203,227,249],"as":[57],"controls.":[58],"Reverse":[59],"transcription-polymerase":[60],"chain":[61],"reaction":[62],"(RT-PCR)":[63],"Western":[65],"blot":[66],"used":[68],"to":[69],"examine":[70],"mRNA":[72,95,114,140],"protein":[74,173,195,212,234,273],"expressions":[75,258],"metabolism-related":[78],"transferring":[79],"(Tf),":[80],"transferrin":[81],"receptor":[82],"(TfR)":[83],"ferritin":[85],"(Fn)":[86],"genes,":[87],"etc.":[88],"RESULTS:":[89],"After":[90,167],"a":[91,168],"48-hour":[92,169],"transfection,":[93,170],"expression":[96,115,137,174,196,213,235],"Tf":[98,194],"had":[99],"no":[100],"statistically":[101,199],"significant":[102],"difference":[103],"among":[104],"three":[105,202],"(F":[107,204],"=":[108,111,205,208],"2.18,":[109],"P":[110,207],"0.078);":[112],"TfR":[117,211,260],"ASODN":[120,143,177,216,238],"significantly":[123,180],"lower":[124,181,219],"than":[125,150,182,220,242],"that":[126,151],"(P":[133,164,190,228,250],"<":[134,165,191,229,251],"0.05).":[135,166,192,230,252],"Fn":[139,233,262],"(0.56":[145],"\u00b1":[146,156,162],"0.06)":[147],"higher":[149,241],"(0.36":[155],"0.05)":[157],"(0.39":[161],"0.03)":[163],"IRP2":[172,254],"those":[183,221,243],"not":[198],"different":[200],"2.67,":[206],"0.088).":[209],"CONCLUSION:":[253],"may":[255],"affect":[256],"adenocarcinoma":[265],"by":[268],"changing":[269],"amount":[271],"metabolism.":[278]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
