{"id":"https://openalex.org/W76683142","doi":"https://doi.org/10.1007/978-1-59745-384-4_13","title":"Anti-glomerular Basement Disease: Goodpasture\u2019s Syndrome","display_name":"Anti-glomerular Basement Disease: Goodpasture\u2019s Syndrome","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W76683142","doi":"https://doi.org/10.1007/978-1-59745-384-4_13","mag":"76683142"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-384-4_13","doi":"https://doi.org/10.1007/978-1-59745-384-4_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-384-4_13","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Basis of Pulmonary Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2490314326","display_name":"Molecular Basis of Pulmonary Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022837409","display_name":"Gangadhar Taduri","orcid":"https://orcid.org/0000-0002-9526-5065","observed_orcids":["https://orcid.org/0000-0002-9526-5065"]},"institutions":[{"id":"https://openalex.org/I139669409","display_name":"Nizam's Institute of Medical Sciences","ror":"https://ror.org/01wjz9118","country_code":"IN","type":"education","lineage":["https://openalex.org/I139669409"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gangadhar Taduri","raw_affiliation_strings":["Department of Nephrology, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India","institution_ids":["https://openalex.org/I139669409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004654560","display_name":"Raghu Kalluri","orcid":"https://orcid.org/0000-0002-2190-547X","observed_orcids":["https://orcid.org/0000-0002-2190-547X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghu Kalluri","raw_affiliation_strings":["Department of Medicine, and Biological Chemistry and Molecular Pharmacology, Center for Matrix Biology, Beth Israel Deaconess, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Biological Chemistry and Molecular Pharmacology, Center for Matrix Biology, Beth Israel Deaconess, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067641826","display_name":"Ralph J. Panos","orcid":"https://orcid.org/0000-0003-4978-7599","observed_orcids":["https://orcid.org/0000-0003-4978-7599"]},"institutions":[{"id":"https://openalex.org/I4210143084","display_name":"Cincinnati VA Medical Center","ror":"https://ror.org/045r80n66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210127612","https://openalex.org/I4210143084"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph J. Panos","raw_affiliation_strings":["Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I4210143084","https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0403115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"275","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/goodpasture-syndrome","display_name":"Goodpasture's syndrome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/anti-gbm-antibodies","display_name":"anti-GBM antibodies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.7570000290870667},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.828000009059906},{"id":"https://openalex.org/keywords/pulmonary-hemorrhage","display_name":"pulmonary hemorrhage","score":0.902999997138977},{"id":"https://openalex.org/keywords/crescentic-glomerulonephritis","display_name":"crescentic glomerulonephritis","score":0.921999990940094},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/autoimmune-disease-pathogenesis","display_name":"autoimmune disease pathogenesis","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2909524538","wikidata":"https://www.wikidata.org/wiki/Q1345792","display_name":"Goodpasture's syndrome","level":4,"score":0.7699006795883179},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.6210991144180298},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6085779070854187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5815776586532593},{"id":"https://openalex.org/C2777234017","wikidata":"https://www.wikidata.org/wiki/Q1345792","display_name":"Goodpasture syndrome","level":5,"score":0.5671674609184265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5344478487968445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5133792161941528},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.47425782680511475},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.45733338594436646},{"id":"https://openalex.org/C2775998817","wikidata":"https://www.wikidata.org/wiki/Q1509367","display_name":"Rapidly progressive glomerulonephritis","level":4,"score":0.42966657876968384},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4259260892868042},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.425731360912323},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.329181969165802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2758585810661316},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.1756558120250702},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12823987007141113},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0953005850315094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-384-4_13","doi":"https://doi.org/10.1007/978-1-59745-384-4_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-384-4_13","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Basis of Pulmonary Disease","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W84084962","https://openalex.org/W122740568","https://openalex.org/W170942874","https://openalex.org/W250751535","https://openalex.org/W1536836644","https://openalex.org/W1597584564","https://openalex.org/W1830633255","https://openalex.org/W1966750531","https://openalex.org/W1970495851","https://openalex.org/W1972452691","https://openalex.org/W1973922709","https://openalex.org/W1977174326","https://openalex.org/W1977316009","https://openalex.org/W1980355423","https://openalex.org/W1987913003","https://openalex.org/W1991090738","https://openalex.org/W1997796758","https://openalex.org/W1998810352","https://openalex.org/W2000078890","https://openalex.org/W2000336674","https://openalex.org/W2004464033","https://openalex.org/W2007155619","https://openalex.org/W2014135469","https://openalex.org/W2014327592","https://openalex.org/W2019828059","https://openalex.org/W2023277595","https://openalex.org/W2024852279","https://openalex.org/W2027031697","https://openalex.org/W2031501484","https://openalex.org/W2031867843","https://openalex.org/W2037359792","https://openalex.org/W2042031358","https://openalex.org/W2043095022","https://openalex.org/W2049085096","https://openalex.org/W2051415098","https://openalex.org/W2055394761","https://openalex.org/W2057998049","https://openalex.org/W2061979277","https://openalex.org/W2065691575","https://openalex.org/W2067272842","https://openalex.org/W2067622134","https://openalex.org/W2070505228","https://openalex.org/W2075048150","https://openalex.org/W2077786824","https://openalex.org/W2079880773","https://openalex.org/W2083137502","https://openalex.org/W2083641348","https://openalex.org/W2086082652","https://openalex.org/W2086439124","https://openalex.org/W2087509528","https://openalex.org/W2091567574","https://openalex.org/W2091720479","https://openalex.org/W2092295832","https://openalex.org/W2096534302","https://openalex.org/W2096877637","https://openalex.org/W2098240796","https://openalex.org/W2102896921","https://openalex.org/W2108079789","https://openalex.org/W2109300653","https://openalex.org/W2122822182","https://openalex.org/W2127923616","https://openalex.org/W2128830838","https://openalex.org/W2130834008","https://openalex.org/W2132596629","https://openalex.org/W2135368684","https://openalex.org/W2141895910","https://openalex.org/W2148690027","https://openalex.org/W2158595140","https://openalex.org/W2161283881","https://openalex.org/W2164569892","https://openalex.org/W2166651089","https://openalex.org/W2167175000","https://openalex.org/W2168466854","https://openalex.org/W2168837021","https://openalex.org/W2169537329","https://openalex.org/W2259573961","https://openalex.org/W2275867151","https://openalex.org/W2277509438","https://openalex.org/W2306510378","https://openalex.org/W2319875445","https://openalex.org/W2325591349","https://openalex.org/W2406052558","https://openalex.org/W2418669621","https://openalex.org/W2419409124","https://openalex.org/W2441077407","https://openalex.org/W3160612059","https://openalex.org/W4236920807"],"related_works":["https://openalex.org/W3171195384","https://openalex.org/W4236330805","https://openalex.org/W2549069016","https://openalex.org/W2153481854","https://openalex.org/W1965956978","https://openalex.org/W2417666099","https://openalex.org/W2593978054","https://openalex.org/W2911490786","https://openalex.org/W2362808393","https://openalex.org/W2038428182"],"abstract_inverted_index":{"Goodpasture\u2019s":[0,78,137],"syndrome":[1],"is":[2,62,126,182],"an":[3,86],"exemplary":[4],"rare":[5],"lung":[6,175],"and":[7,47,98,102,128,145,172,209,223],"kidney":[8],"disease":[9,181,237],"that":[10,22,66,89,121],"has":[11,84,90],"led":[12,91],"to":[13,92],"significant":[14],"discoveries":[15,94],"in":[16,73,133,141,151,173,194],"human":[17],"biology.":[18],"The":[19,54,177,231],"initial":[20,214],"observations":[21],"antibodies":[23,189],"directed":[24],"against":[25,190],"glomerular":[26,170],"basement":[27,39,191],"membrane":[28,192],"(GBM)":[29],"caused":[30],"glomerulonephritis":[31,150],"stimulated":[32],"evaluation":[33,107],"of":[34,37,42,49,52,58,77,108,136,154,162,165,179,187,233,242],"the":[35,38,43,63,74,96,109,122,134,152,159,169,174,185,195,201,217,240],"components":[36],"membrane,":[40],"elucidation":[41],"reticular":[44],"collagen":[45,61,83],"network,":[46],"identification":[48],"different":[50],"types":[51],"collagen.":[53],"\u03b13[IV]":[55,82],"NC1":[56],"domain":[57],"type":[59],"IV":[60],"antigenic":[64],"epitope":[65],"initiates":[67],"a":[68,130],"complex":[69],"autoimmune":[70,104,110],"reaction":[71],"culminating":[72],"clinical":[75,197],"manifestations":[76],"syndrome.":[79,138],"Immunization":[80],"with":[81,168,235],"provided":[85],"experimental":[87],"model":[88],"fundamental":[93],"into":[95],"genetic":[97],"immune":[99,124],"processes":[100],"precipitating":[101],"modulating":[103],"diseases.":[105],"Initial":[106],"process":[111,125],"focused":[112],"on":[113,200,239],"humoral":[114],"mechanisms,":[115,203],"but":[116],"more":[117],"recent":[118],"studies":[119],"suggest":[120],"cellular":[123],"activated":[127],"plays":[129],"key":[131],"role":[132],"pathogenesis":[135],"Hemoptysis":[139],"occurs":[140],"nearly":[142],"all":[143],"patients":[144,234],"renal":[146,243],"histopathology":[147],"demonstrates":[148],"crescentic":[149],"majority":[153],"cases.":[155],"Immunofluorescence":[156],"microscopy":[157],"reveals":[158],"pathognomonic":[160],"finding":[161],"linear":[163],"deposition":[164],"IgG":[166],"along":[167],"capillaries":[171],"parenchyma.":[176],"diagnosis":[178],"anti-GBM":[180,219,236],"confirmed":[183],"by":[184,221,229],"presence":[186],"circulating":[188],"antigen":[193],"correct":[196],"setting.":[198],"Based":[199],"pathogenetic":[202],"therapeutic":[204],"modalities":[205],"include":[206],"both":[207],"induction":[208,212],"maintenance":[210,224],"regimens:":[211],"or":[213],"therapy":[215,225],"removes":[216],"pathogenic":[218],"antibody":[220,227],"plasmapheresis":[222],"reduces":[226],"production":[228],"immunosuppression.":[230],"prognosis":[232],"depends":[238],"level":[241],"dysfunction":[244],"at":[245],"presentation.":[246]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}