{"id":"https://openalex.org/W766052132","doi":null,"title":"Are markers of fibrin turnover in blood and urine increased before and during exacerbation of asthma","display_name":"Are markers of fibrin turnover in blood and urine increased before and during exacerbation of asthma","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W766052132","mag":"766052132"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:33637","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001230965","display_name":"Jonathan Owen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonathan Owen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001230965"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fibrin-turnover","display_name":"fibrin turnover","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fibrin-degradation-products","display_name":"fibrin degradation products","score":0.8339999914169312},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.7799999713897705},{"id":"https://openalex.org/keywords/asthma-biomarkers","display_name":"asthma biomarkers","score":0.7139999866485596},{"id":"https://openalex.org/keywords/coagulation-and-fibrinolysis","display_name":"coagulation and fibrinolysis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8180000185966492},{"id":"https://openalex.org/keywords/eotaxin","display_name":"eotaxin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.8119999766349792},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.5649999976158142},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7799999713897705},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.9099478721618652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7891399264335632},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7528612017631531},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6419637203216553},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5557940602302551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5240659713745117},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.47078579664230347},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4550805985927582},{"id":"https://openalex.org/C2909082789","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma exacerbations","level":3,"score":0.4449783265590668},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3299649953842163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.05689758062362671},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:33637","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:766052132","doi":null,"is_oa":false,"landing_page_url":"http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655172","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:33637","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33637","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W766052132.pdf","grobid_xml":"https://content.openalex.org/works/W766052132.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W387031605","https://openalex.org/W1723887941","https://openalex.org/W1963921406","https://openalex.org/W1970648068","https://openalex.org/W1975896920","https://openalex.org/W1978297748","https://openalex.org/W1979861040","https://openalex.org/W1980358070","https://openalex.org/W1988196846","https://openalex.org/W1988697869","https://openalex.org/W1990681110","https://openalex.org/W1995511753","https://openalex.org/W2000947149","https://openalex.org/W2002520091","https://openalex.org/W2010011258","https://openalex.org/W2019027259","https://openalex.org/W2020043514","https://openalex.org/W2023994993","https://openalex.org/W2031677121","https://openalex.org/W2032255522","https://openalex.org/W2035632341","https://openalex.org/W2040279546","https://openalex.org/W2040681324","https://openalex.org/W2041483144","https://openalex.org/W2067485348","https://openalex.org/W2068299803","https://openalex.org/W2073374778","https://openalex.org/W2076598535","https://openalex.org/W2087196444","https://openalex.org/W2094800640","https://openalex.org/W2095222897","https://openalex.org/W2097498601","https://openalex.org/W2099429774","https://openalex.org/W2099468529","https://openalex.org/W2102175857","https://openalex.org/W2102473788","https://openalex.org/W2102617791","https://openalex.org/W2103871834","https://openalex.org/W2107933686","https://openalex.org/W2111852929","https://openalex.org/W2117559606","https://openalex.org/W2126463704","https://openalex.org/W2132107884","https://openalex.org/W2133469911","https://openalex.org/W2135617966","https://openalex.org/W2136217281","https://openalex.org/W2137035430","https://openalex.org/W2138127317","https://openalex.org/W2139001724","https://openalex.org/W2148879334","https://openalex.org/W2154263136","https://openalex.org/W2159045014","https://openalex.org/W2162301689","https://openalex.org/W2166874624","https://openalex.org/W2288873333","https://openalex.org/W2399350070"],"related_works":["https://openalex.org/W3037764401","https://openalex.org/W3009381459","https://openalex.org/W3094636397","https://openalex.org/W1973371042","https://openalex.org/W2036668002","https://openalex.org/W2166309826","https://openalex.org/W2498903669","https://openalex.org/W2281970259","https://openalex.org/W2390652630","https://openalex.org/W2616462864"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Asthma":[1],"is":[2,330],"a":[3,84,141,195,373,405,430],"chronic":[4],"inflammatory":[5,24,114],"disorder":[6],"of":[7,28,86,110,171,179,194,343,346,407,434],"the":[8,22,169,177,184,317,331,362,417],"airways":[9],"punctuated":[10],"by":[11,106,129,378],"acute":[12,341],"exacerbations.":[13],"Coagulation":[14],"and":[15,26,63,96,115,118,124,140,151,159,190,256,272,298,302,305,307,312,322,338,391,400,409,413],"fibrinolysis":[16,339],"pathways":[17],"are":[18],"increasingly":[19],"recognised":[20],"in":[21,38,58,173,183,316,340,349,361,402,426,439],"asthmatic":[23],"milieu":[25],"markers":[27,109],"fibrin":[29,111],"turnover":[30,112],"represent":[31],"potential":[32,367],"asthma":[33,65,147,181,353,420,435],"biomarkers":[34],"targets.":[35],"A":[36,56],"biomarker":[37],"plasma":[39,403],"or":[40,50,442],"urine":[41,174,197,347],"predicting":[42],"exacerbation":[43,62,95,123,148,158,182,238,269,277,295,321,342,359,436],"could":[44],"enable":[45],"early":[46],"intervention":[47],"to":[48,77,89,98,145,237,270,278,334,351,356,368],"attenuate":[49],"prevent":[51],"exacerbation.":[52,421],"\\n":[53,101,165,327],"\\nSTUDY":[54],"DESIGN:":[55],"study":[57,333,428],"2":[59,81],"parts":[60],"comparing":[61],"stable":[64],"was":[66,104,120,127,143,155,232],"performed.":[67],"Part":[68,80],"1":[69],"compared":[70],"adults":[71],"with":[72],"exacerbations":[73],"requiring":[74],"hospital":[75],"treatment":[76,410],"clinical":[78,99,443],"recovery.":[79,100,125],"prospectively":[82],"followed":[83],"cohort":[85],"adult":[87],"moderate":[88,350],"severe":[90,352],"asthmatics":[91],"when":[92],"well":[93],"until":[94],"through":[97],"\\nMETHODS:":[102],"Plasma":[103,230,247],"analysed":[105,128],"ELISA":[107],"for":[108,132,376,437],"alongside":[113,396],"cellular":[116],"markers,":[117],"comparison":[119],"made":[121,156],"between":[122,157,188,296,387],"Urine":[126],"latex":[130],"agglutination":[131],"fibrin(ogen)":[133],"degradation":[134],"products":[135],"(FDPs).":[136],"Symptoms":[137],"were":[138,292],"recorded":[139],"score":[142,424],"derived":[144],"distinguish":[146],"from":[149,235,268,276],"baseline":[150,236],"recovery":[152,160,325,408],"states.":[153],"Comparison":[154],"using":[161],"multivariate":[162],"statistical":[163],"analysis.":[164],"\\nKEY":[166],"FINDINGS:":[167],"Prospectively,":[168],"detection":[170],"FDP":[172,198,200,210,220,348],"significantly":[175,233,267,274],"increased":[176,234,266,275,315,358,397],"likelihood":[178],"subsequent":[180,363],"following":[185],"7-14":[186],"days":[187,202,212,222,319],"4":[189,394],"6":[191],"times":[192],"that":[193],"negative":[196],"test.":[199],"+7":[201],"(OR":[203,213,223],"4.35":[204],"(95%":[205,215,225,242,251,261],"CI":[206,216,226,243,252,262,286],"1.12,":[207],"16.9)":[208],"p=0.03),":[209],"+10":[211],"5.50":[214],"1.38,":[217],"21.9)":[218],"p=0.02),":[219],"+14":[221],"6.07":[224],"1.43,":[227],"25.8)":[228],"p=0.02).":[229,246],"D-dimer":[231],"(median":[239,249,258,281],"0.07":[240],"\u03bcgFEU/ml":[241],"-0.01,":[244],"0.15)":[245],"eosinophils":[248,297,308,399],"10*9/l":[250],"0.10,":[253],"0.29)":[254],"p=0.02)":[255],"eotaxin":[257,299,401],"12":[259],"pg/ml":[260],"3,":[263],"22)":[264],"p<0.001)":[265],"recovery,":[271],"PF4":[273,303],"follow":[279],"up":[280,355],"9":[282],"\u03bcg/ml":[283],"(95":[284],"%":[285],"2,":[287],"17),":[288],"p=0.002).":[289],"Positive":[290,385],"correlations":[291,386],"observed":[293],"at":[294,380],"(p<0.001),":[300],"platelets":[301,306,390],"(p=0.02)":[304],"(p=0.01).":[309],"Clinical":[310],"symptoms":[311],"reliever":[313],"use":[314,377,438],"10":[318],"preceding":[320],"reduced":[323],"during":[324,419],"(p<0.001).":[326],"\\nCONCLUSIONS:":[328],"This":[329],"largest":[332],"date":[335],"examining":[336],"coagulation":[337],"asthma.":[344],"Detection":[345],"suggests":[354],"6-fold":[357],"risk":[360],"14":[364],"days.":[365],"The":[366,422],"translate":[369],"these":[370],"findings":[371],"into":[372,416],"point-of-care":[374],"test":[375],"patients":[379],"home":[381],"warrants":[382],"further":[383],"study.":[384],"eosinophils,":[388],"eotaxin,":[389],"platelet":[392,414],"factor":[393],"(PF4)":[395],"PF4,":[398],"after":[404],"period":[406],"support":[411],"eosinophil":[412],"migration":[415],"lung":[418],"symptom":[423],"used":[425],"this":[427],"provides":[429],"simple":[431],"objective":[432],"measure":[433],"future":[440],"research":[441],"practice":[444],"but":[445],"requires":[446],"prospective":[447],"validation.":[448]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}