{"id":"https://openalex.org/W76560811","doi":null,"title":"Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis.","display_name":"Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis.","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W76560811","mag":"76560811","pmid":"https://pubmed.ncbi.nlm.nih.gov/23544716"},"language":"en","primary_location":{"id":"pmid:23544716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23544716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067968646","display_name":"Mark J. Tullman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802222712","display_name":"Missouri Baptist Medical Center","ror":"https://ror.org/0067dx910","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328499231","https://openalex.org/I2802222712"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark J Tullman","raw_affiliation_strings":["Center for Innovations in Care, Missouri Baptist Medical Center, St Louis, Missouri, USA. mjt2796@bjc.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovations in Care, Missouri Baptist Medical Center, St Louis, Missouri, USA. mjt2796@bjc.org","institution_ids":["https://openalex.org/I2802222712"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067968646"],"corresponding_institution_ids":["https://openalex.org/I2802222712"],"apc_list":null,"apc_paid":null,"fwci":12.8709,"has_fulltext":false,"cited_by_count":251,"citation_normalized_percentile":{"value":0.99294652,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"19","issue":"2 Suppl","first_page":"S15","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.7799999713897705},{"id":"https://openalex.org/keywords/relapsing-remitting-disease","display_name":"relapsing-remitting disease","score":0.8220000267028809},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.7639999985694885},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.652999997138977},{"id":"https://openalex.org/keywords/genetic-and-environmental-risk-factors","display_name":"genetic and environmental risk factors","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9615603685379028},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7525080442428589},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6933308243751526},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5347458720207214},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44533541798591614},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.41084933280944824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2915271520614624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20722457766532898},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:23544716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23544716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},{"id":"mag:76560811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23544716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1833759296","https://openalex.org/W1986173197","https://openalex.org/W2023555055","https://openalex.org/W2027145449","https://openalex.org/W2082422372","https://openalex.org/W2101489349","https://openalex.org/W2105490558","https://openalex.org/W2113485611","https://openalex.org/W2113577022","https://openalex.org/W2113948549","https://openalex.org/W2122545833","https://openalex.org/W2135900660","https://openalex.org/W2148563799","https://openalex.org/W2164351607","https://openalex.org/W2326826867","https://openalex.org/W2328652388"],"related_works":["https://openalex.org/W4211179677","https://openalex.org/W11385159","https://openalex.org/W7208806868","https://openalex.org/W4405001181","https://openalex.org/W1548976614","https://openalex.org/W7161017268","https://openalex.org/W1825094415","https://openalex.org/W2776773517","https://openalex.org/W2922378843","https://openalex.org/W4405000708"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3,27,31],"a":[4,36,61,68],"chronic":[5],"inflammatory":[6],"demyelinating":[7],"disease":[8,78],"of":[9,25,35,51,70,86,93],"the":[10,20,33,45,84,88,94,97],"central":[11],"nervous":[12],"system":[13],"that":[14],"affects":[15],"approximately":[16],"400,000":[17],"people":[18],"in":[19],"United":[21],"States.":[22],"The":[23,48],"etiology":[24],"MS":[26,52,100],"unknown,":[28],"but":[29,56],"it":[30],"likely":[32],"result":[34,69],"complex":[37],"interaction":[38],"between":[39],"genetic":[40],"and":[41,44,90,96],"environmental":[42],"factors":[43],"immune":[46],"system.":[47],"clinical":[49],"manifestations":[50],"are":[53],"highly":[54],"variable,":[55],"most":[57],"patients":[58],"initially":[59],"experience":[60],"relapsing-remitting":[62],"course.":[63],"Patients":[64],"accumulate":[65],"disability":[66],"as":[67],"incomplete":[71],"recovery":[72],"from":[73],"acute":[74],"exacerbations":[75],"and/or":[76],"gradual":[77],"progression.":[79],"This":[80],"article":[81],"briefly":[82],"reviews":[83],"immunopathology":[85],"MS,":[87],"symptoms":[89],"natural":[91],"course":[92],"disease,":[95],"recently":[98],"revised":[99],"diagnostic":[101],"criteria.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":39},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}