{"id":"https://openalex.org/W76515573","doi":"https://doi.org/10.5283/epub.29627","title":"The alpha-substitution of chalcones as a tool to modulate the reactivity and biological activity","display_name":"The alpha-substitution of chalcones as a tool to modulate the reactivity and biological activity","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W76515573","doi":"https://doi.org/10.5283/epub.29627","mag":"76515573"},"language":"en","primary_location":{"id":"pmh:oai:epub.uni-regensburg.de:29627","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/29627/1/Nafisah%20Al-Rifai_Dissertation_Chemie_13.3.2014.pdf","pdf_url":"https://epub.uni-regensburg.de/29627/1/Nafisah%20Al-Rifai_Dissertation_Chemie_13.3.2014.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"parent_works":[],"lineage":["https://openalex.org/W76515573"],"child_works_count":0,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5283/epub.29627","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067676812","display_name":"Nafisah Al\u2010Rifai","orcid":"https://orcid.org/0000-0003-3128-052X","observed_orcids":["https://orcid.org/0000-0003-3128-052X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Al-Rifai, Nafisah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067676812"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chalcones","display_name":"chalcones","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alpha-substitution","display_name":"\u03b1-substitution","score":0.9629999995231628},{"id":"https://openalex.org/keywords/michael-acceptors","display_name":"Michael acceptors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/electrophilicity","display_name":"electrophilicity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.824999988079071},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nitric-oxide-inhibition","display_name":"nitric oxide inhibition","score":0.7429999709129333},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cf3-substituent","display_name":"CF3 substituent","score":0.5299999713897705},{"id":"https://openalex.org/keywords/privileged-structures","display_name":"privileged structures","score":0.4099999964237213},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.8190000057220459},{"id":"https://openalex.org/keywords/kinetic-assay","display_name":"kinetic assay","score":0.3790000081062317},{"id":"https://openalex.org/keywords/solvent-effects-on-reactivity","display_name":"solvent effects on reactivity","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.8069930076599121},{"id":"https://openalex.org/C2780764945","wikidata":"https://www.wikidata.org/wiki/Q899416","display_name":"Chalcone","level":2,"score":0.7932993173599243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7023099660873413},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.6531420350074768},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5293259024620056},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23776012659072876},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.13380974531173706},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:epub.uni-regensburg.de:29627","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/29627/1/Nafisah%20Al-Rifai_Dissertation_Chemie_13.3.2014.pdf","pdf_url":"https://epub.uni-regensburg.de/29627/1/Nafisah%20Al-Rifai_Dissertation_Chemie_13.3.2014.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-027211916","doi":null,"is_oa":false,"landing_page_url":"http://epub.uni-regensburg.de/29627/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"doi:10.5283/epub.29627","doi":"https://doi.org/10.5283/epub.29627","is_oa":true,"landing_page_url":"https://doi.org/10.5283/epub.29627","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:76515573","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/29627/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.5283/epub.29627","doi":"https://doi.org/10.5283/epub.29627","is_oa":true,"landing_page_url":"https://doi.org/10.5283/epub.29627","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965767470","https://openalex.org/W2137605946","https://openalex.org/W4200254164","https://openalex.org/W2039543356","https://openalex.org/W3198936119","https://openalex.org/W2092697120","https://openalex.org/W2921636259","https://openalex.org/W4377835249","https://openalex.org/W2082106397","https://openalex.org/W6903780219"],"abstract_inverted_index":{"The":[0,87,177,225,242,353],"chalcone":[1],"motif":[2],"can":[3,33],"be":[4,270,321,421],"a":[5,18,29,64,123,251,290,300],"privileged":[6],"structure":[7,296],"in":[8,91,130,255,271,429],"drug":[9],"design":[10],"if":[11,377],"the":[12,41,54,73,83,92,113,121,165,173,190,195,214,266,272,279,295,312,350,374,378,381,385,388,391,405,424],"reactivity":[13,36,42,58,114,166,253,261],"is":[14,48,59,126,247,371,387],"modulated":[15],"to":[16,71,188,249,257,269,310,320,358,393,400,413,420],"reach":[17],"suitable":[19],"range.":[20],"Chalcones":[21],"are":[22,318],"relatively":[23],"easily":[24],"synthesized":[25,342],"and":[26,208,287,343,411],"they":[27],"have":[28],"structural":[30],"versatility":[31],"that":[32,128,245,289,368,417],"affect":[34],"their":[35,51,186,304,325,344],"as":[37,45],"Michael":[38,46,205],"acceptors.":[39],"Since":[40],"of":[43,56,60,75,96,115,137,158,167,180,192,210,213,274,297,314,355,390,407,415],"chalcones":[44,76,116,169,298,316,357],"acceptors":[47],"essential":[49,248],"for":[50,132,216,278,404,434],"biological":[52,345],"activity,":[53],"assessment":[55],"this":[57,133,369,383],"great":[61],"interest.":[62],"Hence,":[63],"new":[65],"simple":[66,292],"kinetic":[67,175,267],"assay":[68,93,268],"was":[69,106,117,162,170,182,202,263,284,308,347,360,366,418,431],"developed":[70,174],"study":[72],"electrophilicity":[74],"upon":[77],"reaction":[78,406],"with":[79,98,140,349,409],"thiols":[80,410],"by":[81,119,194,265,328,362,373,423],"determining":[82],"second-order":[84],"rate":[85],"constants.":[86],"solvent":[88],"system":[89],"used":[90],"permits":[94],"inclusion":[95],"compounds":[97],"quite":[99],"diverse":[100,159],"electrophilicity.":[101],"A":[102,135,199,427],"clear":[103],"structure-activity":[104],"relationship":[105],"shown":[107],"within":[108],"16":[109],"alpha-H-chalcones.":[110],"After":[111],"that,":[112],"fine-tuned":[118],"modifying":[120],"alpha-position,":[122],"strategy":[124],"which":[125,317],"not":[127],"common":[129],"literature":[131],"aim.":[134],"library":[136],"alpha-X-2',3,4,4'-tetramethoxychalcones":[138],"(alpha-X-TMCs)":[139],"different":[141],"X-":[142],"substituents":[143],"(H,":[144],"F,":[145,220,336],"CN,":[146,334],"Me,":[147,335],"Br,":[148,222,338],"Cl,":[149,221,337],"I,":[150,223],"p-NO2-C6H4,":[151],"Ph,":[152],"p-OMe-C6H4,":[153],"NO2,":[154],"COOEt,":[155],"COOH,":[156],"CF3)":[157],"electronic":[160],"properties":[161],"prepared.":[163],"Then":[164],"these":[168,356],"assessed":[171],"utilizing":[172],"assay.":[176],"anti-inflammatory":[178],"activity":[179,207,228,313,346,416,430],"alpha-X-TMCs":[181,215],"evaluated":[183],"based":[184],"on":[185,294,303],"ability":[187,376],"inhibit":[189],"production":[191,212],"NO":[193,211],"proinflammatory":[196],"enzyme":[197],"iNOS.":[198],"strong":[200],"correlation":[201],"found":[203,367],"between":[204],"acceptor":[206],"inhibition":[209],"X":[217],"=":[218,333],"H,":[219],"CF3.":[224],"chemical":[226],"reactivity-biological":[227],"order":[229,256],"is:":[230],"CF3":[231],">":[232,234,236,238,240],"Br":[233],"Cl":[235],"I":[237],"H":[239],"F.":[241],"data":[243],"prove":[244],"it":[246,283,307,398],"find":[250],"certain":[252],"window":[254,262],"retain":[258],"activity.":[259,305],"This":[260,395],"identified":[264],"range":[273],"2-20":[275],"M-1":[276],"s-1":[277],"k2":[280],"values.":[281],"So,":[282],"proven":[285,319,361],"chemically":[286],"biologically":[288],"single":[291],"modification":[293],"has":[299],"tremendous":[301],"effect":[302],"Finally,":[306],"tried":[309],"enhance":[311],"2\u2019-OH":[315,425],"more":[322,382],"active":[323],"than":[324],"2\u2019-alkoxy":[326],"analogues":[327],"alpha-substitution.":[329],"Seven":[330],"alpha-X-HCs":[331,392,408],"(X":[332],"CF3,":[339],"p-NO2-C6H4)":[340],"were":[341],"compared":[348],"corresponding":[351],"alpha-X-TMCs.":[352],"conversion":[354],"flavanones":[359],"LC-MS":[363],"analysis.":[364],"It":[365],"isomerization":[370],"affected":[372],"electron-withdrawing":[375],"X-substituent,":[379],"i.e.":[380],"ability,":[384],"higher":[386],"tendency":[389],"cyclize.":[394],"cyclization":[396],"made":[397],"difficult":[399],"get":[401],"clean":[402],"kinetics":[403],"led":[412],"loss":[414],"supposed":[419],"enhanced":[422],"group.":[426],"gain":[428],"observed":[432],"only":[433],"alpha-CN-HC.":[435]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}