{"id":"https://openalex.org/W762878865","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1140.2","title":"Bisphenol A decreases BK channel expression in rat aorta via genomic mechanisms","display_name":"Bisphenol A decreases BK channel expression in rat aorta via genomic mechanisms","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W762878865","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1140.2","mag":"762878865"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.1140.2","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1140.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.1140.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060547181","display_name":"Shinichi Asano","orcid":"https://orcid.org/0000-0001-6655-1970","observed_orcids":["https://orcid.org/0000-0001-6655-1970"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinichi Asano","raw_affiliation_strings":["Exercise Physiology West Virginia University Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exercise Physiology West Virginia University Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011693232","display_name":"Ibra Seaphus Fancher","orcid":"https://orcid.org/0000-0003-4677-6755","observed_orcids":["https://orcid.org/0000-0003-4677-6755"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibra Seaphus Fancher","raw_affiliation_strings":["Exercise Physiology West Virginia University Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exercise Physiology West Virginia University Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038570981","display_name":"Gregory M. Dick","orcid":"https://orcid.org/0000-0003-1444-6436","observed_orcids":["https://orcid.org/0000-0003-1444-6436"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M Dick","raw_affiliation_strings":["Exercise Physiology West Virginia University Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exercise Physiology West Virginia University Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.2206,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54993621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nuclear-estrogen-receptor","display_name":"nuclear estrogen receptor","score":0.8289999961853027},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.7599999904632568},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.675000011920929},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C61144316","wikidata":"https://www.wikidata.org/wiki/Q4835827","display_name":"BK channel","level":3,"score":0.7517949938774109},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6695159077644348},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6552976369857788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6526114344596863},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.5953753590583801},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5371900796890259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5251074433326721},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5118715167045593},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.48886364698410034},{"id":"https://openalex.org/C2779684741","wikidata":"https://www.wikidata.org/wiki/Q271980","display_name":"Bisphenol A","level":3,"score":0.43858349323272705},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4285103678703308},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42399224638938904},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.42055752873420715},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3573458790779114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2969016432762146},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.2353454828262329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2134857177734375},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.21116605401039124},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17630347609519958},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.14185455441474915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09303450584411621},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08698692917823792},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C166595027","wikidata":"https://www.wikidata.org/wiki/Q143983","display_name":"Epoxy","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.1140.2","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1140.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.1140.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2305215792","https://openalex.org/W2293084022","https://openalex.org/W1738362859","https://openalex.org/W2070830402","https://openalex.org/W2286518556","https://openalex.org/W2954305300","https://openalex.org/W2895097849","https://openalex.org/W1973152525","https://openalex.org/W4323925314","https://openalex.org/W4309245797"],"abstract_inverted_index":{"Bisphenol":[0],"A":[1],"(BPA)":[2],"is":[3,178],"an":[4,154],"estrogenic":[5],"endocrine":[6],"disruptor":[7],"associated":[8],"with":[9,100],"a":[10,23],"variety":[11],"of":[12,36,49,61,119,139],"pathologies":[13],"that":[14,73,160],"have":[15],"raised":[16],"public":[17],"health":[18],"concerns.":[19],"Epidemiological":[20],"studies":[21],"show":[22],"relationship":[24],"between":[25],"urinary":[26],"BPA":[27,37,62,74,115,140,161,176],"levels":[28],"and":[29,91,111,124,147,169],"cardiovascular":[30,40,181],"diseases,":[31],"but":[32],"the":[33,39,47,71,117],"molecular":[34],"actions":[35],"on":[38,63],"system":[41],"remain":[42],"largely":[43],"unknown.":[44,68],"Estrogen":[45],"regulates":[46,75],"expression":[48,66,78,104,118,165],"large":[50],"conductance":[51],"voltage/Ca":[52],"2+":[53],"\u2010activated":[54],"K":[55],"+":[56],"(BK)":[57],"channels;":[58],"however,":[59],"effects":[60],"BK":[64,76,102,120,128,143,163],"channel":[65,77,103,144,164],"are":[67],"We":[69],"tested":[70],"hypothesis":[72],"though":[79],"genomic":[80],"mechanisms":[81],"involving":[82],"nuclear":[83,167],"estrogen":[84],"receptors":[85],"(ER).":[86],"Rat":[87],"aortae":[88],"were":[89],"harvested":[90],"placed":[92],"in":[93,132],"tissue":[94],"culture":[95],"for":[96],"48\u201372":[97],"hour":[98],"treatment":[99],"BPA.":[101],"was":[105,130,149],"determined":[106],"by":[107,151,174,184],"RT\u2010PCR,":[108],"Western":[109],"blot,":[110],"whole\u2010cell":[112],"patch":[113],"clamp.":[114],"decreased":[116],"\u03b1":[121],"subunit":[122],"mRNA":[123],"protein.":[125],"Penitrem":[126],"A\u2010sensitive":[127],"current":[129,148],"reduced":[131],"cells":[133],"from":[134],"BPA\u2010treated":[135],"aortae.":[136],"The":[137],"effect":[138],"to":[141,180],"reduce":[142],"mRNA,":[145],"protein,":[146],"blocked":[150],"ICI":[152],"182,780,":[153],"ER":[155,168],"antagonist.":[156],"These":[157],"data":[158],"suggest":[159],"decreases":[162],"via":[166],"may":[170],"represent":[171],"one":[172],"mechanism":[173],"which":[175],"exposure":[177],"linked":[179],"disease.":[182],"Supported":[183],"T\u201032":[185],"HL\u2010090610.":[186]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
