{"id":"https://openalex.org/W762657640","doi":null,"title":"\u91cd\u5e86\u6c49\u65cf\u513f\u7ae5IL-18\u57fa\u56e0\u542f\u52a8\u5b50\uff0d137G/C\u591a\u6001\u6027\u53ca\u86cb\u767d\u8868\u8fbe\u4e0e\u7ed3\u6838\u75c5\u6613\u611f\u6027\u7684\u5173\u7cfb","display_name":"\u91cd\u5e86\u6c49\u65cf\u513f\u7ae5IL-18\u57fa\u56e0\u542f\u52a8\u5b50\uff0d137G/C\u591a\u6001\u6027\u53ca\u86cb\u767d\u8868\u8fbe\u4e0e\u7ed3\u6838\u75c5\u6613\u611f\u6027\u7684\u5173\u7cfb","publication_year":2008,"publication_date":"2008-09-28","ids":{"openalex":"https://openalex.org/W762657640","mag":"762657640"},"language":"zh","primary_location":{"id":"mag:762657640","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=02533626-200809-33-9-1029-1033-a","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062592874","display_name":"\u5468\u8d85","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5468\u8d85","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061304849","display_name":"\u848b\u5229\u840d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u848b\u5229\u840d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u738b\u6625\u71d5","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u738b\u6625\u71d5","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010421638","display_name":"\u6731\u671d\u654f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6731\u671d\u654f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022963307","display_name":"\u89e3\u5143\u5143","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u89e3\u5143\u5143","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028596962","display_name":"\u5218\u73ae","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5218\u73ae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084052903","display_name":"\u9646\u5f6a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u9646\u5f6a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077602147","display_name":"\u6768\u9521\u5f3a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6768\u9521\u5f3a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06223506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"9","first_page":"1029","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-18-gene","display_name":"IL-18 gene","score":0.8519999980926514},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tuberculosis-susceptibility","display_name":"tuberculosis susceptibility","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pediatric-tuberculosis","display_name":"pediatric tuberculosis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/han-chinese-children","display_name":"Han Chinese children","score":0.8930000066757202},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5669999718666077},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.847883403301239},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7078207731246948},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6012284755706787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5449485182762146},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5265879034996033},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4933604300022125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4866412580013275},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.47965458035469055},{"id":"https://openalex.org/C175239580","wikidata":"https://www.wikidata.org/wiki/Q656595","display_name":"Genotype frequency","level":5,"score":0.43362754583358765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41028571128845215},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38527822494506836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34393608570098877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32538217306137085},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19374582171440125}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:762657640","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=02533626-200809-33-9-1029-1033-a","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2392138781","https://openalex.org/W2179977712","https://openalex.org/W2092363165","https://openalex.org/W2042252266","https://openalex.org/W2014642388","https://openalex.org/W2349878839","https://openalex.org/W1563027836","https://openalex.org/W2754364520","https://openalex.org/W3151422683","https://openalex.org/W2351140112"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"the":[3,81,97,110,113,162],"association":[4],"of":[5,29,52,65,83,99,164,180],"IL-18":[6,30,47,123,143,165,172],"gene":[7,31,144],"promoter":[8,32,145,163],"SNPs":[9],"with":[10,121,126,130,170],"susceptibility":[11,151],"to":[12,152],"TB":[13,35,72,153,181],"and":[14,26,38,88,101,112],"its":[15],"protein":[16],"production":[17,124],"in":[18,33,49,71,77,154],"Chongqing":[19,155],"Han":[20,156],"children.":[21,157],"Methods:":[22],"Polymorphisms":[23],"at":[24,103,147,161],"-137":[25,149],"-607":[27,104],"locus":[28],"113":[34],"child":[36],"patients":[37,73,111],"167":[39],"healthy":[40,56],"controls":[41,78],"were":[42,58,68,93,105],"detected":[43],"by":[44,60],"SSP-PCR.":[45],"The":[46,63,139],"productions":[48],"cultured":[50],"supernatants":[51],"PBMCs":[53],"from":[54],"46":[55],"children":[57],"measured":[59],"ELISA.":[61],"Results:":[62],"frequency":[64],"IL-18-137GG":[66],"genotype":[67,117,128],"significantly":[69,119],"higher":[70],"(81.4%)":[74],"than":[75],"that":[76,142],"(67.7%)(P=0.01),":[79],"while":[80],"frequencies":[82,98],"-137GC":[84,127],"genotype(1.8%":[85],"vs":[86,91],"3.6%)":[87],"-137C":[89],"allele(10.2%":[90],"18.0%)":[92],"conversely":[94],"lower(p\uff1c0.05),":[95],"but":[96],"alleles":[100],"genotypes":[102],"not":[106],"statistically":[107],"significant":[108],"between":[109],"controls.":[114],"Furthermore,":[115],"-137GG":[116],"was":[118],"associated":[120,169],"lower":[122],"compared":[125],"when":[129],"or":[131],"without":[132],"PMA+A23":[133],"187":[134],"stimulation":[135],"for":[136],"24h.":[137],"Conclusions:":[138],"results":[140],"showed":[141],"polymorphisms":[146],"position":[148],"confer":[150],"Subjects":[158],"carrying-137G":[159],"allele":[160],"gene,":[166],"which":[167],"is":[168],"lowered":[171],"level,":[173],"may":[174],"be":[175],"a":[176],"high":[177],"risk":[178],"population":[179],"development.":[182]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}