{"id":"https://openalex.org/W76206663","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.673.1","title":"Direct procaspase activation as a therapeutic strategy in the treatment of canine lymphoma","display_name":"Direct procaspase activation as a therapeutic strategy in the treatment of canine lymphoma","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W76206663","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.673.1","mag":"76206663"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.673.1","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.673.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.673.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088809420","display_name":"Quinn P. Peterson","orcid":"https://orcid.org/0000-0001-8701-0575","observed_orcids":["https://orcid.org/0000-0001-8701-0575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quinn P Peterson","raw_affiliation_strings":["Department of Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064924141","display_name":"Diana C. West-Szymanski","orcid":"https://orcid.org/0000-0002-2933-1159","observed_orcids":["https://orcid.org/0000-0002-2933-1159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana C. West","raw_affiliation_strings":["Department of Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021860262","display_name":"Danny Chung Hsu","orcid":"https://orcid.org/0000-0002-9577-5401","observed_orcids":["https://orcid.org/0000-0002-9577-5401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danny C. Hsu","raw_affiliation_strings":["Department of Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058163249","display_name":"Rachel C. Botham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel C. Botham","raw_affiliation_strings":["Department of Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012219010","display_name":"Timothy M. Fan","orcid":"https://orcid.org/0000-0003-2510-7050","observed_orcids":["https://orcid.org/0000-0003-2510-7050"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy M. Fan","raw_affiliation_strings":["School of Veterinary Medicine, University of Illinois-Urbana Champaign, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, University of Illinois-Urbana Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027996458","display_name":"Paul J. Hergenrother","orcid":"https://orcid.org/0000-0001-9018-3581","observed_orcids":["https://orcid.org/0000-0001-9018-3581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul J. Hergenrother","raw_affiliation_strings":["Department of Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00613778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pac-1","display_name":"PAC-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/procaspase-3","display_name":"procaspase-3","score":0.8700000047683716},{"id":"https://openalex.org/keywords/canine-lymphoma","display_name":"canine lymphoma","score":0.8209999799728394},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/zinc-chelation","display_name":"zinc chelation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.6869999766349792},{"id":"https://openalex.org/keywords/small-molecule-activators","display_name":"small molecule activators","score":0.5130000114440918},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.7146962881088257},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6563630104064941},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5981141328811646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5430026650428772},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5345202088356018},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49612411856651306},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4954873323440552},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4577106833457947},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.45626261830329895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4329086244106293},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42688149213790894},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41581615805625916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2731136977672577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2454296052455902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2309439778327942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21021050214767456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18567928671836853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.673.1","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.673.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.673.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096608863","https://openalex.org/W2582276699","https://openalex.org/W1984341140","https://openalex.org/W7096800402","https://openalex.org/W7095778629","https://openalex.org/W2003436246","https://openalex.org/W2590829335","https://openalex.org/W3173789415","https://openalex.org/W37375449","https://openalex.org/W2605789072"],"abstract_inverted_index":{"General":[0],"cytotoxins":[1],"that":[2,56,118,139,152],"induce":[3,70],"cell":[4,10],"death":[5,71,125],"in":[6,49,62,73,103,121,126,129,132,143,160,172,178,231],"all":[7],"rapidly":[8],"dividing":[9],"types":[11],"have":[12],"been":[13],"the":[14,52,84,97,100,161,173,183,221],"backbone":[15],"of":[16,47,54,83,86,99,147,157,175,226,229],"chemotherapy":[17],"for":[18,38,169,206],"over":[19],"50":[20],"years.":[21],"These":[22],"drugs":[23],"are":[24],"most":[25],"properly":[26],"classified":[27],"as":[28,33,194],"\u201canti\u2010proliferatives\u201d":[29],"rather":[30],"than":[31],"\u201canti\u2010cancer\u201d":[32],"they":[34],"exhibit":[35],"little":[36],"selectivity":[37],"cancer":[39,74,87,104,127],"cells":[40,75,79,128],"versus":[41],"non\u2010cancerous":[42],"cells.":[43,64,105],"A":[44,106],"burgeoning":[45],"area":[46],"focus":[48],"oncology":[50],"is":[51,88,96,182],"identification":[53],"compounds":[55],"target":[57],"a":[58,89,93,167,190,199,204,214,227],"defined":[59],"molecular":[60],"defect":[61],"cancerous":[63],"This":[65],"targeted":[66],"approach":[67,95],"would":[68],"thus":[69],"specifically":[72],"while":[76],"leaving":[77],"non\u2010cancer":[78],"unharmed.":[80],"As":[81],"one":[82],"hallmarks":[85],"resistance":[90],"to":[91,188],"apoptosis,":[92],"promising":[94],"reactivation":[98],"apoptotic":[101],"program":[102],"compound":[107,110],"called":[108],"procaspase\u2010activating":[109],"1":[111],"(":[112],"PAC\u20101":[113,140,153,181,196,230],")":[114],"was":[115],"recently":[116,215],"reported":[117,187],"activates":[119,141],"procaspase\u20103":[120,142,208],"vitro":[122,144],"and":[123,131,151,193,203,224],"induces":[124],"culture":[130],"mouse":[133],"xenograft":[134],"models.":[135],"Experimental":[136],"evidence":[137],"indicates":[138],"through":[145],"chelation":[146],"inhibitory":[148],"zinc":[149,171],"ions":[150],"colocalizes":[154],"with":[155,234],"points":[156],"caspase\u20103":[158],"activity":[159,177],"cell.":[162],"Importantly,":[163],"these":[164],"results":[165],"suggest":[166],"role":[168],"endogenous":[170],"regulation":[174],"caspase":[176],"vivo":[179],".":[180],"first":[184],"small":[185],"molecule":[186],"activate":[189],"proenzyme":[191],"protease,":[192],"such":[195],"could":[197],"be":[198],"useful":[200],"anti\u2010cancer":[201],"agent":[202],"model":[205],"other":[207],"activating":[209],"compounds.":[210],"To":[211],"this":[212],"end,":[213],"initiated":[216],"canine":[217],"clinical":[218],"trial":[219],"investigates":[220],"safety,":[222],"toxicity":[223],"efficacy":[225],"derivative":[228],"pet":[232],"dogs":[233],"lymphoma.":[235]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
