{"id":"https://openalex.org/W7617034","doi":"https://doi.org/10.4049/jimmunol.184.supp.98.12","title":"Administration of dendritic cells signaled via the neurokinin 1 receptor favors type-1 cellular immunity by mechanisms involving exogenous and endogenous dendritic cell populations (98.12)","display_name":"Administration of dendritic cells signaled via the neurokinin 1 receptor favors type-1 cellular immunity by mechanisms involving exogenous and endogenous dendritic cell populations (98.12)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W7617034","doi":"https://doi.org/10.4049/jimmunol.184.supp.98.12","mag":"7617034"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.98.12","doi":"https://doi.org/10.4049/jimmunol.184.supp.98.12","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.98.12","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039789994","display_name":"Brian Janelsins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Janelsins","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020014585","display_name":"Alicia R. Mathers","orcid":"https://orcid.org/0000-0001-6931-8605","observed_orcids":["https://orcid.org/0000-0001-6931-8605"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Mathers","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Olga Tkacheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Tkacheva","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085214095","display_name":"G\u00e9za Erd\u00f6s","orcid":"https://orcid.org/0000-0001-7530-7371","observed_orcids":["https://orcid.org/0000-0001-7530-7371"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geza Erdos","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113607518","display_name":"William J. Shufesky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Shufesky","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053100074","display_name":"Adri\u00e1n E. Morelli","orcid":"https://orcid.org/0000-0002-1172-7200","observed_orcids":["https://orcid.org/0000-0002-1172-7200"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Morelli","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068430075","display_name":"Adriana T. Larregina","orcid":"https://orcid.org/0000-0002-6713-5466","observed_orcids":["https://orcid.org/0000-0002-6713-5466"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Larregina","raw_affiliation_strings":["Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Immunology and Surgery, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"1Departments of Dermatology, Immunology and Surgery. University of Pittsburgh School of Medicine., Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"98.12","last_page":"98.12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neurokinin-1-receptor","display_name":"neurokinin-1 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hemokinin-1","display_name":"hemokinin-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/type-1-immunity","display_name":"type 1 immune response","score":0.8309999704360962},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/il-12p70","display_name":"IL-12p70","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/t-cell-stimulation","display_name":"T cell stimulation","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.7056788802146912},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6258376836776733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6047340631484985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5921346545219421},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5790612697601318},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.46504226326942444},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45373597741127014},{"id":"https://openalex.org/C137130169","wikidata":"https://www.wikidata.org/wiki/Q15316325","display_name":"Tachykinin receptor 1","level":5,"score":0.45092931389808655},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4461807906627655},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4336926341056824},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42055055499076843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.356751024723053},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.31254518032073975},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.1981385350227356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06605908274650574}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.98.12","doi":"https://doi.org/10.4049/jimmunol.184.supp.98.12","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.98.12","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W961851934","https://openalex.org/W2078515335","https://openalex.org/W2220069915","https://openalex.org/W134098781","https://openalex.org/W1544251926","https://openalex.org/W2016272979","https://openalex.org/W1593911267","https://openalex.org/W169862144","https://openalex.org/W2125264712","https://openalex.org/W4313382203"],"abstract_inverted_index":{"Abstract":[0],"Induction":[1],"of":[2,8,43,55,67,95,105,109,128,146,160,168,173,180,193],"type-1":[3,81,116,147,169,197],"immunity":[4,28,148,170,198],"is":[5],"the":[6,31,41,48,60,65,73,90,93,144,203],"focus":[7],"current":[9],"dendritic":[10],"cell":[11,50,78],"(DC)-vaccination":[12],"approaches":[13],"for":[14],"tumors":[15],"and":[16,24,52,80,101,119,132,154,178,206],"intracellular":[17],"infections.":[18],"The":[19,125],"pro-inflammatory":[20],"neuropeptides,":[21],"substance":[22],"P":[23],"hemokinin-1,":[25],"favor":[26],"cell-mediated":[27],"by":[29,142,175,182,199],"binding":[30],"neurokinin":[32],"1":[33],"receptor":[34],"(NK1R).":[35],"DCs":[36,56,70,99],"express":[37],"functional":[38],"NK1R;":[39],"however,":[40],"ability":[42],"NK1R":[44,74,91],"agonists":[45],"to":[46,75],"modulate":[47],"T":[49,77],"stimulatory":[51,79],"biasing":[53,82],"functions":[54],"remains":[57],"unknown.":[58],"In":[59],"present":[61],"work,":[62],"we":[63],"analyzed":[64],"effects":[66],"ex":[68],"vivo-generated":[69],"signaled":[71],"via":[72,89],"exert":[76],"functions.":[83],"We":[84],"demonstrate":[85,165],"that":[86,166,190],"agonistic":[87],"signaling":[88],"promotes":[92,196],"maturation":[94],"murine":[96],"bone":[97],"marrow-derived":[98],"(BMDCs)":[100],"inhibits":[102],"their":[103],"secretion":[104,179],"IL-10.":[106],"Adoptive":[107],"transfer":[108,192],"NK1R-signaled":[110,194],"BMDCs":[111,131,177,195],"favors":[112],"enhanced":[113],"Ag":[114],"specific":[115],"CD4+":[117],"(Th1)":[118],"CD8+":[120],"(CTL/Tc1)":[121],"responses":[122],"in":[123,149],"vivo.":[124],"individual":[126],"roles":[127],"adoptively":[129,204],"transferred":[130,176,205],"endogenous":[133,161,183,207],"DCs,":[134],"under":[135],"our":[136,186],"experimental":[137],"conditions,":[138],"were":[139],"further":[140],"addressed":[141],"comparing":[143],"development":[145],"C57BL/6":[150],"wild":[151],"type,":[152],"IL-12p35-/-":[153],"CD11c+DTR":[155],"mice":[156],"(the":[157],"latter":[158],"depleted":[159],"DCs).":[162],"Our":[163],"results":[164],"generation":[167],"required":[171],"inhibition":[172],"IL-10":[174],"IL-12p70":[181],"DCs.":[184],"Together,":[185],"data":[187],"strongly":[188],"suggest":[189],"adoptive":[191],"mechanisms":[200],"involving":[201],"both":[202],"DC":[208],"populations.":[209]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
