{"id":"https://openalex.org/W76041018","doi":null,"title":"Beta-adrenoceptors desensitization may modulate catecholamine induced insulin resistance in human pheochromocytoma.","display_name":"Beta-adrenoceptors desensitization may modulate catecholamine induced insulin resistance in human pheochromocytoma.","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W76041018","mag":"76041018","pmid":"https://pubmed.ncbi.nlm.nih.gov/2560726"},"language":"en","primary_location":{"id":"pmid:2560726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2560726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113770971","display_name":"S. Di Paolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S di Paolo","raw_affiliation_strings":["Clinica Medica III, Universit\u00e0 di Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Medica III, Universit\u00e0 di Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011035895","display_name":"Giovanni De Pergola","orcid":"https://orcid.org/0000-0003-0020-3273","observed_orcids":["https://orcid.org/0000-0003-0020-3273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G de Pergola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082466451","display_name":"Maria Rosaria Cospite","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Cospite","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032891061","display_name":"Edoardo Guastamacchia","orcid":"https://orcid.org/0000-0001-8666-8658","observed_orcids":["https://orcid.org/0000-0001-8666-8658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Guastamacchia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025291956","display_name":"Mauro Cignarelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Cignarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047615180","display_name":"Anna Balice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Balice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082466451","display_name":"Maria Rosaria Cospite","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Cospite","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001397612","display_name":"Giovanni Maria Nardelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Nardelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059558211","display_name":"Ruben Giorgino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Giorgino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7189,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67817006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"15","issue":"6","first_page":"409","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-receptor-desensitization","display_name":"beta-adrenergic receptor desensitization","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8289999961853027},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/insulin-receptor-binding","display_name":"insulin receptor binding","score":0.7429999709129333},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.7559999823570251},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.6759999990463257},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8349999785423279},{"id":"https://openalex.org/keywords/receptor-redistribution","display_name":"receptor redistribution","score":0.5299999713897705},{"id":"https://openalex.org/keywords/extra-adrenal-pheochromocytoma","display_name":"extra-adrenal pheochromocytoma","score":0.8270000219345093},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8828799724578857},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8758265972137451},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6316655278205872},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.6075942516326904},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.569434642791748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5105127096176147},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5031382441520691},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.47244054079055786},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.46810388565063477},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.46316325664520264},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.46308642625808716},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.45803382992744446},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.44323161244392395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36966103315353394}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2560726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2560726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Case Reports"},{"id":"pmh:oai:ricerca.uniba.it:11586/215586","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/215586","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:76041018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2560726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141460159","https://openalex.org/W4246706218","https://openalex.org/W2047375631","https://openalex.org/W7098063323","https://openalex.org/W2051520745","https://openalex.org/W2027380640","https://openalex.org/W2904355205","https://openalex.org/W2036321939","https://openalex.org/W1992314756","https://openalex.org/W7095184891"],"abstract_inverted_index":{"Catecholamines":[0],"acutely":[1],"exert":[2],"a":[3,40,52,183,229,240],"pronounced":[4],"insulin-antagonistic":[5],"effect,":[6],"which":[7],"is":[8],"mediated":[9],"by":[10,86],"beta-adrenergic":[11,114,187,249],"receptors":[12,115,188],"stimulation.":[13],"Nevertheless,":[14],"several":[15],"patients":[16],"with":[17,239],"pheochromocytoma":[18],"fail":[19],"to":[20,38,57,73,126,145,227],"exhibit":[21],"an":[22,47],"overt":[23],"diabetic":[24],"syndrome,":[25],"in":[26,77,190,196,244],"spite":[27],"of":[28,33,117,141,186,206,223,231,243,248],"steadily":[29,99],"elevated":[30],"plasma":[31,96,103],"levels":[32,97,222],"catecholamines.":[34],"This":[35],"prompted":[36],"us":[37],"investigate":[39],"16":[41],"years":[42],"old":[43],"male":[44],"patient,":[45],"bearing":[46],"extra-adrenal":[48],"pheochromocytoma,":[49],"who":[50],"displayed":[51],"slightly":[53,92],"impaired":[54],"glucose":[55,59,214],"tolerance":[56,60,89],"oral":[58],"test,":[61,90],"whereas":[62],"fasting":[63,106],"and":[64,107,168,234],"post-prandial":[65],"blood":[66],"glucose,":[67],"as":[68,70,84,150,209,211],"well":[69,151,210],"glycaemic":[71],"response":[72],"intravenous":[74,87],"glucagon,":[75],"were":[76,98,216,225],"the":[78,111,191,203,212],"normal":[79,112,165],"range.":[80,113],"Peripheral":[81],"insulin":[82,88,160,235],"sensitivity,":[83],"evaluated":[85],"was":[91,109,121,148,163,172],"decreased.":[93],"Supine":[94],"norepinephrine":[95,224],"upon":[100],"9":[101],"ng/ml;":[102],"insulin,":[104],"both":[105,232],"post-prandial,":[108],"within":[110],"density":[116,189],"peripheral":[118],"mononuclear":[119],"cells":[120,193],"strongly":[122],"reduced":[123,149],"when":[124],"compared":[125],"controls":[127],"(0.97":[128],"+/-":[129,133,153,157],"0.08":[130],"vs":[131,155],"2.82":[132],"0.37":[134],"fmol/10(6)":[135],"cells),":[136],"without":[137],"any":[138],"concomitant":[139],"change":[140],"affinity.":[142],"Insulin":[143],"binding":[144],"circulating":[146],"monocytes":[147],"(2.38":[152],"0.27":[154],"5.1":[156],"0.4%/10(7)":[158],"monocytes);":[159],"receptor":[161,170,207,236],"affinity":[162],"quite":[164],"(1.7":[166],"ng/ml)":[167],"total":[169],"number":[171],"9,200":[173],"sites/cell.":[174],"In":[175],"desensitization":[176],"experiments,":[177],"1":[178],"microM":[179],"isoproterenol":[180],"caused":[181],"only":[182],"20%":[184],"decrease":[185,195,230],"patient's":[192],"(70%":[194],"controls).":[197],"Six":[198],"months":[199],"after":[200],"surgery,":[201],"all":[202],"above":[204],"modifications":[205],"binding,":[208,237],"mild":[213],"intolerance,":[215],"almost":[217],"completely":[218],"reversed.":[219],"Thus,":[220],"high":[221],"able":[226],"induce":[228],"beta-adrenoceptor":[233],"together":[238],"marked":[241],"reduction":[242],"vitro":[245],"agonist-induced":[246],"redistribution":[247],"receptors.(ABSTRACT":[250],"TRUNCATED":[251],"AT":[252],"250":[253],"WORDS)":[254]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
