{"id":"https://openalex.org/W760219469","doi":null,"title":"Investigation of the function of Retionid X Receptor in mouse bone marrow-derived macrophages using novel genomic approaches","display_name":"Investigation of the function of Retionid X Receptor in mouse bone marrow-derived macrophages using novel genomic approaches","publication_year":2014,"publication_date":"2014-11-04","ids":{"openalex":"https://openalex.org/W760219469","mag":"760219469"},"language":"en","primary_location":{"id":"pmh:oai:dea.lib.unideb.hu:2437/199739","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/199739","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2437/199739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067791915","display_name":"Bence D\u00e1niel","orcid":"https://orcid.org/0000-0002-2410-8767","observed_orcids":["https://orcid.org/0000-0002-2410-8767"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bence D\u00e1niel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2410-8767","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067791915"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02336951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8100000023841858},{"id":"https://openalex.org/keywords/enhancer-rna","display_name":"enhancer RNA","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nascent-rna","display_name":"nascent RNA","score":0.9120000004768372},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.7239999771118164},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.953000009059906},{"id":"https://openalex.org/keywords/litaf","display_name":"LITAF","score":0.968999981880188},{"id":"https://openalex.org/keywords/chorioallantoic-membrane-assay","display_name":"chorioallantoic membrane assay","score":0.9190000295639038},{"id":"https://openalex.org/keywords/genome-wide-gene-expression-profiling","display_name":"genome-wide gene expression profiling","score":0.4580000042915344},{"id":"https://openalex.org/keywords/chromatin-immunoprecipitation","display_name":"chromatin immunoprecipitation","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6662082076072693},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6290974617004395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46231043338775635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4617356061935425},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4485812485218048},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40128013491630554},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.306155800819397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26121920347213745},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08013308048248291}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dea.lib.unideb.hu:2437/199739","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/199739","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:760219469","doi":null,"is_oa":false,"landing_page_url":"https://dea.lib.unideb.hu/dea/handle/2437/199739","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dea.lib.unideb.hu:2437/199739","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/199739","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2617029264","https://openalex.org/W2910519670","https://openalex.org/W7096083430","https://openalex.org/W7155217841","https://openalex.org/W2414204272","https://openalex.org/W1992438813","https://openalex.org/W7054798885","https://openalex.org/W7100137914","https://openalex.org/W7201915908","https://openalex.org/W196579538"],"abstract_inverted_index":{"In":[0,215],"our":[1,197],"study":[2],"we":[3,24,36,46,66,114,159,189,228],"focused":[4],"on":[5,124,142,240],"the":[6,9,21,26,29,38,58,77,83,97,104,116,119,132,143,167,177,219,224,231,241,248,258,264,279],"action":[7,27],"of":[8,20,28,82,118,176,226,245,266,277,289],"activated":[10,249],"RXR":[11,84,170,194,220,250,259,315,361,457,472,483,505,523],"nuclear":[12],"receptor":[13,30,59,340,347,370,381],"in":[14,31,54,150,223,301],"bone":[15],"marrow-derived":[16],"macrophages.":[17],"Taking":[18],"advantage":[19],"technological":[22],"developments":[23],"determined":[25],"a":[32,151,202,267,302,328,339,365,369,393,409,424,427,446,462,544],"genome-wide":[33],"manner.":[34,309],"\\nFirst,":[35],"identified":[37],"regulated":[39,70,105,260,280],"gene":[40,125],"network":[41,205,262,285],"by":[42,51],"using":[43,110],"RNA-sequencing,":[44],"then":[45],"performed":[47],"chromatin":[48],"immunoprecipitation":[49],"followed":[50],"deep":[52],"sequencing":[53,113],"order":[55,216],"to":[56,88,103,162,182,187,217,296],"find":[57],"bound":[60],"genomic":[61],"loci.":[62],"Using":[63],"these":[64,199,254],"methods":[65,179],"found":[67],"approximately":[68],"800":[69,372],"genes":[71,99,106,158,186,200,281],"and":[72,127,282,305],"5200":[73,376],"binding":[74],"sites":[75,85],"for":[76,210,286],"receptor.":[78],"Interestingly,":[79],"almost":[80],"90%":[81],"are":[86,148],"located":[87],"intergenic":[89],"regions,":[90],"often":[91],"more":[92],"than":[93],"100kb":[94],"far":[95],"from":[96,135],"closest":[98],"thus":[100,294],"their":[101,156,163,283],"annotation":[102],"remained":[107],"elusive.":[108],"By":[109],"global":[111],"run-on":[112,404],"analyzed":[115],"amount":[117],"freshly":[120],"synthesized":[121],"nascent":[122],"RNA":[123],"bodies":[126],"as":[128,138,155],"reported":[129],"previously":[130],"also":[131],"transcripts":[133],"originated":[134],"cis-elements":[136],"known":[137],"enhancer":[139,146],"RNAs.":[140],"Based":[141],"fact":[144],"that":[145,257],"RNAs":[147],"induced":[149],"very":[152],"similar":[153],"manner":[154],"targeted":[157],"assigned":[160],"them":[161],"potential":[164],"targets,":[165],"yielding":[166],"transcriptionally":[168],"active":[169],"cis-element/gene":[171],"pair":[172],"network.":[173],"The":[174],"combination":[175],"aforementioned":[178],"let":[180],"us":[181],"identify":[183],"252":[184,478],"target":[185],"which":[188,236],"could":[190],"assign":[191],"414":[192,471],"cis-acting":[193],"elements.":[195],"To":[196],"surprise,":[198],"showed":[201],"convergent":[203],"angiogenic":[204,243],"consisting":[206],"well-known":[207],"agiogenesis":[208],"inducers,":[209],"example:":[211],"Vegfa,":[212,501],"Hbegf,":[213,502],"Litaf.":[214,503],"characterize":[218],"programed":[221],"macrophages":[222,246],"context":[225],"angiogenesis":[227],"carried":[229],"out":[230],"well-accepted":[232],"chorioallantoic":[233],"membrane":[234],"assay,":[235],"unequivocally":[237],"shed":[238],"light":[239],"improved":[242],"capacity":[244],"harboring":[247],"program.":[251],"Taken":[252],"together,":[253],"results":[255],"show":[256],"gene/cis-element":[261],"promotes":[263],"establishment":[265],"pro-angiogenic":[268],"macrophage":[269],"phenotype.":[270],"\\nOur":[271],"highly":[272],"integrated":[273],"method":[274],"is":[275,491],"capable":[276],"identifying":[278],"cis-element":[284],"any":[287],"kind":[288],"signal":[290],"specific":[291],"transcription":[292,303],"factor":[293,304],"able":[295],"reveal":[297],"new":[298],"biological":[299],"functions":[300],"cell":[306],"type":[307],"dependent":[308],"\\nA":[310,346],"k\u00eds\u00e9rleteink":[311],"sor\u00e1n":[312],"az":[313,360,442,456,482,494,522],"aktiv\u00e1lt":[314],"magreceptor":[316],"hat\u00e1s\u00e1nak":[317],"molekul\u00e1ris":[318],"mechanizmus\u00e1t":[319],"\u00e9s":[320],"funkci\u00f3j\u00e1t":[321],"vizsg\u00e1latunk":[322],"eg\u00e9r":[323],"csontvel\u0151i":[324],"eredet\u0171":[325],"makrof\u00e1gokban.":[326],"Kihaszn\u00e1lva":[327],"technol\u00f3giai":[329],"fejl\u0151d\u00e9s":[330],"adta":[331],"metodikai":[332],"\u00faj\u00edt\u00e1sokat,":[333],"teljes":[334,416],"genom":[335,417],"szinten":[336],"hat\u00e1roztuk":[337],"meg":[338],"m\u0171k\u00f6d\u00e9s\u00e9t":[341],"\u00faj-gener\u00e1ci\u00f3s":[342],"szekven\u00e1l\u00e1shoz":[343],"kapcsolt":[344,357],"m\u00f3dszerekkel.":[345],"\u00e1ltal":[348,473,484,507,524],"szab\u00e1lyozott":[349,474,485,525],"g\u00e9nh\u00e1l\u00f3zat":[350],"azonos\u00edt\u00e1s\u00e1hoz":[351],"RNS":[352,413],"szekven\u00e1l\u00e1st":[353],"haszn\u00e1ltunk.":[354],"Kromatin":[355],"immunprecipit\u00e1ci\u00f3hoz":[356],"szekven\u00e1l\u00e1ssal":[358],"meghat\u00e1roztuk":[359,454],"genomi":[362],"k\u00f6t\u0151helyeit.":[363],"Ezekb\u0151l":[364],"k\u00eds\u00e9reltekb\u0151l":[366],"kider\u00fclt,":[367],"hogy":[368,422,521],"hozz\u00e1vet\u0151leg":[371],"g\u00e9nt":[373,490],"szab\u00e1lyoz,":[374],"ami":[375],"k\u00f6t\u0151helyr\u0151l":[377],"val\u00f3sulhat":[378],"meg.":[379],"A":[380,402,466],"k\u00f6t\u0151helyei":[382],"majdnem":[383],"90%-ban":[384],"intergenikus":[385],"r\u00e9gi\u00f3kban":[386],"tal\u00e1lhat\u00f3k,":[387],"sokszor":[388],"t\u00f6bb":[389,488],"sz\u00e1z":[390],"kilob\u00e1zisos":[391],"t\u00e1vols\u00e1gra":[392],"g\u00e9nekt\u0151l,":[394],"\u00edgy":[395],"ezek":[396],"g\u00e9nekhez":[397],"val\u00f3":[398],"annot\u00e1l\u00e1sa":[399],"nem":[400],"megb\u00edzhat\u00f3.":[401],"glob\u00e1lis":[403],"technol\u00f3gia":[405],"felhaszn\u00e1l\u00e1s\u00e1val":[406],"k\u00e9pesek":[407],"voltunk":[408],"frissen":[410],"keletkezett":[411],"naszcens":[412],"mennyis\u00e9g\u00e9t":[414],"detekt\u00e1lni":[415],"szinten.":[418],"Irodalmi":[419],"adatok":[420],"igazolj\u00e1k,":[421],"ez":[423],"met\u00f3dus":[425,542],"k\u00e9pes":[426],"transzkripci\u00f3s":[428,464,549],"szab\u00e1lyoz\u00e1sban":[429],"akt\u00edvan":[430],"r\u00e9szt":[431,460],"vev\u0151":[432],"cisz-elemek":[433],"kimutat\u00e1s\u00e1ra,":[434],"mivel":[435],"ezekr\u0151l":[436],"\u00fagynevezett":[437],"enhanszer":[438],"transzkriptek":[439],"keletkeznek,":[440],"amelyek":[441,459,493],"aktiv\u00e1l\u00f3":[443],"stimulus":[444],"hat\u00e1s\u00e1ra":[445,547],"c\u00e9lg\u00e9nen":[447],"t\u00f6rt\u00e9n\u0151":[448],"transzkripci\u00f3":[449],"m\u00e9rt\u00e9k\u00e9t":[450],"k\u00f6vetik.":[451],"Ezt":[452],"kihaszn\u00e1lva":[453],"azokat":[455],"k\u00f6t\u0151helyeket,":[458],"vesznek":[461],"g\u00e9nek":[463],"szab\u00e1lyoz\u00e1s\u00e1ban.":[465],"fent":[467],"eml\u00edtett":[468],"m\u00f3dszerek":[469,539],"integr\u00e1ci\u00f3j\u00e1val":[470],"cisz-elemet":[475],"kapcsoltunk":[476],"\u00f6ssze":[477],"c\u00e9lg\u00e9nnel.":[479],"\u00c9rdekes":[480],"m\u00f3don":[481],"g\u00e9n/cisz-elem":[486,526],"h\u00e1l\u00f3zat":[487,527],"olyan":[489],"tartalmazott,":[492],"angiogenezis":[495,514],"indukci\u00f3j\u00e1ban":[496],"j\u00e1tszanak":[497],"jelent\u0151s":[498],"szerepet,":[499],"p\u00e9ld\u00e1ul:":[500],"Az":[504,517],"aktiv\u00e1tor":[506],"programozott":[508],"makrof\u00e1gokat":[509],"ezut\u00e1n":[510],"chorioallantois":[511],"membr\u00e1non":[512],"v\u00e9gzett":[513],"k\u00eds\u00e9rletekben":[515],"tesztelt\u00fck.":[516],"eredm\u00e9nyeink":[518],"egy\u00e9rtelm\u0171en":[519],"bebizony\u00edtott\u00e1k,":[520],"egy":[528],"\u00e9rk\u00e9pz\u0151d\u00e9st":[529],"el\u0151seg\u00edt\u0151":[530],"makrof\u00e1g":[531],"fenot\u00edpus":[532],"kialak\u00edt\u00e1s\u00e1\u00e9rt":[533],"felel\u0151s.":[534],"\\nAz":[535],"\u00e1ltalunk":[536],"kifejlesztett,":[537],"genomikai":[538],"kombin\u00e1ci\u00f3j\u00e1n":[540],"alapul\u00f3":[541],"alkalmas":[543],"k\u00fcl\u00f6nb\u00f6z\u0151":[545],"szign\u00e1lok":[546],"bekapcsol\u00f3d\u00f3":[548],"faktorok":[550],"biol\u00f3giai":[551],"funkci\u00f3inak":[552],"felt\u00e1r\u00e1s\u00e1hoz,":[553],"gyakorlatilag":[554],"b\u00e1rmilyen":[555],"sejtt\u00edpusban.":[556]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}