{"id":"https://openalex.org/W75932010","doi":"https://doi.org/10.1007/978-1-60327-087-8_50","title":"Neoadjuvant Approaches in Melanoma","display_name":"Neoadjuvant Approaches in Melanoma","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W75932010","doi":"https://doi.org/10.1007/978-1-60327-087-8_50","mag":"75932010"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60327-087-8_50","doi":"https://doi.org/10.1007/978-1-60327-087-8_50","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-087-8_50","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"From Local Invasion to Metastatic Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2492411437","display_name":"From Local Invasion to Metastatic Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020955148","display_name":"Ahmad A. Tarhini","orcid":"https://orcid.org/0000-0002-3193-9702","observed_orcids":["https://orcid.org/0000-0002-3193-9702"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad A. Tarhini","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007239425","display_name":"John M. Kirkwood","orcid":"https://orcid.org/0000-0002-3570-4476","observed_orcids":["https://orcid.org/0000-0002-3570-4476"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Kirkwood","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06649778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"599","last_page":"605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/regional-lymph-node-metastasis","display_name":"regional lymph node metastasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/biochemotherapy","display_name":"biochemotherapy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6110000014305115},{"id":"https://openalex.org/keywords/lymph-node-dissection","display_name":"lymph node dissection","score":0.765999972820282},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8957892060279846},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7307250499725342},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6163537502288818},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5328503251075745},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5292519927024841},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.45148733258247375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4490828216075897},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.4474383592605591},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44398415088653564},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44312524795532227},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44095584750175476},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.43215465545654297},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4217243790626526},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.41900983452796936},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30049756169319153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25879934430122375},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16665184497833252},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07453939318656921},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-60327-087-8_50","doi":"https://doi.org/10.1007/978-1-60327-087-8_50","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-087-8_50","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"From Local Invasion to Metastatic Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W65675808","https://openalex.org/W100794221","https://openalex.org/W311157107","https://openalex.org/W1828940258","https://openalex.org/W1908752382","https://openalex.org/W1951046932","https://openalex.org/W1955397179","https://openalex.org/W1975918912","https://openalex.org/W1988395666","https://openalex.org/W1998978540","https://openalex.org/W1999468766","https://openalex.org/W2001646586","https://openalex.org/W2047181127","https://openalex.org/W2066704699","https://openalex.org/W2070703301","https://openalex.org/W2078142473","https://openalex.org/W2078197336","https://openalex.org/W2107580116","https://openalex.org/W2112410464","https://openalex.org/W2118449798","https://openalex.org/W2119174775","https://openalex.org/W2120041024","https://openalex.org/W2121276929","https://openalex.org/W2122352172","https://openalex.org/W2131365547","https://openalex.org/W2147090478","https://openalex.org/W4323053376"],"related_works":["https://openalex.org/W1558265941","https://openalex.org/W2164599562","https://openalex.org/W2112410464","https://openalex.org/W2242027575","https://openalex.org/W2405914707","https://openalex.org/W4367332794","https://openalex.org/W2070703301","https://openalex.org/W4285728850","https://openalex.org/W2953597066","https://openalex.org/W3200550458"],"abstract_inverted_index":{"Patients":[0],"with":[1,26,41,65,77,81,109,138,162,259,275],"clinically":[2],"palpable":[3],"regional":[4,28,164],"lymph":[5,29],"node":[6,30],"metastases":[7],"(AJCC":[8],"stage":[9,165],"IIIB-C)":[10],"carry":[11],"a":[12,204],"risk":[13],"of":[14,35,56,58,69,96,150,154,188,207,225,231,237,253,257,270],"relapse":[15],"and":[16,79,170,178,201,213,233,245,267],"death":[17],"that":[18,129,240],"approaches":[19],"70%":[20],"at":[21],"5":[22],"years.":[23],"Surgical":[24],"excision":[25],"complete":[27],"dissection":[31],"is":[32,89,194,217],"the":[33,54,67,70,94,115,148,186,208,214,223,229,235,251,264],"cornerstone":[34],"management,":[36],"followed":[37],"by":[38],"adjuvant":[39],"therapy":[40,46,97,157,272],"high-dose":[42],"interferon-\u03b12b":[43],"(HDI).":[44],"Neoadjuvant":[45],"has":[47,132],"been":[48],"demonstrated":[49],"to":[50,92,121,196,222,261],"improve":[51],"outcome":[52],"in":[53,135,191],"management":[55],"patients":[57,64,108,137,161,274],"multiple":[59],"different":[60],"solid":[61],"tumors.":[62],"In":[63],"melanoma,":[66],"quality":[68],"host":[71,116],"immune":[72,87,215],"response":[73,180],"differs":[74],"between":[75,211],"those":[76,80],"earlier":[78],"more":[82,119],"advanced":[83,99],"disease":[84],"settings.":[85],"Host":[86],"tolerance":[88],"now":[90],"understood":[91],"impede":[93],"results":[95,172],"for":[98,107,158,228,273],"disease,":[100,113],"but":[101],"may":[102,117,143,241],"be":[103,118],"less":[104,246],"an":[105],"issue":[106],"microscopic":[110],"high-risk":[111,159],"operable":[112],"where":[114,141],"susceptible":[120],"immunologic":[122],"interventions.":[123],"Phase":[124],"II":[125],"studies":[126],"have":[127,173,242],"shown":[128,174],"neoadjuvant":[130,155,189],"biochemotherapy":[131],"limited":[133],"activity":[134],"melanoma":[136,160,232],"local-regional":[139],"metastases,":[140],"chemotherapy":[142],"potentially":[144],"antagonize":[145],"or":[146],"alter":[147],"effects":[149],"immunotherapeutic":[151],"agents.":[152],"Studies":[153],"HDI":[156,260],"bulky":[163],"IIIB-C":[166],"lymphadenopathy":[167],"are":[168],"ongoing":[169],"preliminary":[171],"unexpectedly":[175],"high":[176],"clinical":[177],"pathologic":[179],"rates,":[181],"without":[182],"increased":[183],"morbidity.":[184],"Through":[185],"design":[187],"trials":[190],"which":[192],"it":[193],"possible":[195],"obtain":[197],"biopsy":[198],"samples":[199],"before":[200],"after":[202],"therapy,":[203],"greater":[205,243],"understanding":[206],"dynamic":[209],"interaction":[210],"tumors":[212],"system":[216],"possible.":[218],"This":[219,248],"should":[220],"lead":[221],"identification":[224],"new":[226,238,255],"targets":[227],"treatment":[230],"aid":[234],"development":[236],"immunotherapies":[239],"specificity":[244],"toxicity.":[247],"will":[249],"simplify":[250],"evaluation":[252],"promising":[254],"combinations":[256],"agents":[258],"build":[262],"on":[263],"clinical,":[265],"immunologic,":[266],"molecular":[268],"effect":[269],"this":[271],"melanoma.":[276]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
