{"id":"https://openalex.org/W75916947","doi":null,"title":"Analysis of a naturally occurring HLA class I-restricted viral epitope.","display_name":"Analysis of a naturally occurring HLA class I-restricted viral epitope.","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W75916947","mag":"75916947","pmid":"https://pubmed.ncbi.nlm.nih.gov/7525458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414868"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1414868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414868","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414868","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024159365","display_name":"Kirsten Falk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Falk","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Biologie, Abteilung Immungenetik, Universit\u00e4t T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Biologie, Abteilung Immungenetik, Universit\u00e4t T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073296118","display_name":"Olaf R\u00f6tzschke","orcid":"https://orcid.org/0000-0001-8336-5248","observed_orcids":["https://orcid.org/0000-0001-8336-5248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O R\u00f6tzschke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012626247","display_name":"Stefan Stevanovi\u0107","orcid":"https://orcid.org/0000-0001-7430-1437","observed_orcids":["https://orcid.org/0000-0001-7430-1437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Stevanovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067358405","display_name":"Volker Gnau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Gnau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048848554","display_name":"Katrin Sparbier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sparbier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080130690","display_name":"G. Jung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Jung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090153362","display_name":"Hans\u2010Georg Rammensee","orcid":"https://orcid.org/0000-0003-1614-2647","observed_orcids":["https://orcid.org/0000-0003-1614-2647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H G Rammensee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050072303","display_name":"Peter Walden","orcid":"https://orcid.org/0000-0002-8986-3667","observed_orcids":["https://orcid.org/0000-0002-8986-3667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Walden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7431,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.64514372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"82","issue":"3","first_page":"337","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-a-0201","display_name":"HLA-A*0201","score":0.8939999938011169},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.6729999780654907},{"id":"https://openalex.org/keywords/matrix-protein","display_name":"matrix protein","score":0.9629999995231628},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mhc-class-i-restriction","display_name":"MHC class I restriction","score":0.7350000143051147},{"id":"https://openalex.org/keywords/epitope-variants","display_name":"epitope variants","score":0.5669999718666077},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/t-cell-stimulation","display_name":"T cell stimulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/synthetic-peptides","display_name":"synthetic peptides","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9384962320327759},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6998459100723267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6343588829040527},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6245815753936768},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6116200685501099},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5602016448974609},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5326162576675415},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5089271068572998},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.49353086948394775},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.48051390051841736},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.46612098813056946},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.4246298372745514},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42361798882484436},{"id":"https://openalex.org/C78598654","wikidata":"https://www.wikidata.org/wiki/Q17140316","display_name":"Linear epitope","level":4,"score":0.4191647171974182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22169554233551025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19277775287628174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19095778465270996},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16245019435882568}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1414868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414868","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:7525458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7525458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:75916947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7525458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1414868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414868","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1516591549","https://openalex.org/W1520197177","https://openalex.org/W1761998434","https://openalex.org/W1967582433","https://openalex.org/W1971302107","https://openalex.org/W2011352102","https://openalex.org/W2015595559","https://openalex.org/W2035620466","https://openalex.org/W2035937996","https://openalex.org/W2052383501","https://openalex.org/W2063929734","https://openalex.org/W2064888792","https://openalex.org/W2066493864","https://openalex.org/W2082173837","https://openalex.org/W2099028937","https://openalex.org/W2111441225","https://openalex.org/W2113334969","https://openalex.org/W2153918116","https://openalex.org/W2156906426","https://openalex.org/W2164339006","https://openalex.org/W2169643581","https://openalex.org/W2333849587"],"related_works":["https://openalex.org/W2063929734","https://openalex.org/W1533163141","https://openalex.org/W2042285023","https://openalex.org/W2055220017","https://openalex.org/W1889652211","https://openalex.org/W2223211809","https://openalex.org/W2066493864","https://openalex.org/W2022995076","https://openalex.org/W6977147461","https://openalex.org/W1968299739"],"abstract_inverted_index":{"A":[0,33],"previously":[1],"described":[2],"nonapeptide":[3],"sequence":[4,45],"motif":[5],"for":[6],"antigens":[7],"recognized":[8],"by":[9,55,117],"T":[10,97],"cells":[11],"in":[12,77,112],"the":[13,16,28,41,44,48,52,57,60,72,84,93,106,121],"context":[14],"of":[15,31,51,59,66,71,92,105,109,123],"human":[17],"major":[18],"histocompatibility":[19],"complex":[20],"(MHC)":[21],"molecule":[22],"HLA-A2.1":[23],"was":[24,87,115],"used":[25],"to":[26],"identify":[27],"natural":[29,53],"epitope":[30,54,85,94],"influenza":[32],"virus":[34],"matrix":[35],"protein.":[36],"We":[37],"show":[38],"here":[39],"that":[40],"peptide":[42,62],"with":[43,89],"GILGFVFTL":[46],"is":[47],"synthetic":[49,90],"analogue":[50],"demonstrating":[56],"presence":[58],"corresponding":[61],"on":[63,120],"MHC":[64],"molecules":[65],"virus-infected":[67],"cells.":[68,101],"The":[69,102],"role":[70,104],"hydrophobic":[73],"anchor":[74],"amino":[75,110],"acids":[76,111],"positions":[78,114],"2":[79],"and":[80,95],"9,":[81],"which":[82],"constitute":[83],"motif,":[86],"investigated":[88],"variants":[91],"cytotoxic":[96],"lymphocytes":[98],"as":[99],"indicator":[100],"crucial":[103],"side":[107],"chains":[108],"those":[113],"evidence":[116],"their":[118],"influence":[119],"efficiency":[122],"T-cell":[124],"stimulation.":[125]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
