{"id":"https://openalex.org/W75913038","doi":null,"title":"The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.","display_name":"The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W75913038","mag":"75913038","pmid":"https://pubmed.ncbi.nlm.nih.gov/7039877","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536329"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1536329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113759361","display_name":"Robbert Benner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Benner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036819854","display_name":"Willy Hijmans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Hijmans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084430234","display_name":"Joost J. Haaijman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Haaijman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8095,"has_fulltext":false,"cited_by_count":358,"citation_normalized_percentile":{"value":0.93563756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"46","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immunoglobulin-secreting-cells","display_name":"immunoglobulin-secreting cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.8650000095367432},{"id":"https://openalex.org/keywords/antibody-producing-cells","display_name":"antibody-forming cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.5329999923706055},{"id":"https://openalex.org/keywords/immunization-response","display_name":"immunization response","score":0.6110000014305115},{"id":"https://openalex.org/keywords/secondary-immune-response","display_name":"secondary immune response","score":0.800000011920929},{"id":"https://openalex.org/keywords/secondary-lymphoid-organs","display_name":"secondary lymphoid organs","score":0.8140000104904175},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.6060000061988831},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7614099383354187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6515393257141113},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6417648792266846},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.6319890022277832},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.6253174543380737},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6099796295166016},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5948953628540039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.591559648513794},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5396087765693665},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.43707555532455444},{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.41902703046798706},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3320724070072174},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24665701389312744},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.20797857642173767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20780032873153687}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000921","descriptor_name":"Antibody-Producing Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006462","descriptor_name":"Hemolytic Plaque Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1536329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:7039877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7039877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:oai-pmh.tno.nl:74824","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:df35c700-d22b-46d6-a908-32bcfe5c672b","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and experimental immunology, 46, pp. 1-8.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:75913038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7039877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1536329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W150116065","https://openalex.org/W172528368","https://openalex.org/W186590573","https://openalex.org/W206601913","https://openalex.org/W297921291","https://openalex.org/W1484669342","https://openalex.org/W1488868563","https://openalex.org/W1495823673","https://openalex.org/W1513846717","https://openalex.org/W1521036695","https://openalex.org/W1538436890","https://openalex.org/W1550379078","https://openalex.org/W1556648307","https://openalex.org/W1561292787","https://openalex.org/W1562414717","https://openalex.org/W1565367768","https://openalex.org/W1566014256","https://openalex.org/W1603012697","https://openalex.org/W1663483145","https://openalex.org/W1779504031","https://openalex.org/W1849844634","https://openalex.org/W1990828245","https://openalex.org/W1999546336","https://openalex.org/W2010789437","https://openalex.org/W2012274565","https://openalex.org/W2029450096","https://openalex.org/W2031357360","https://openalex.org/W2032675071","https://openalex.org/W2037373282","https://openalex.org/W2044555549","https://openalex.org/W2047973672","https://openalex.org/W2060248408","https://openalex.org/W2077688540","https://openalex.org/W2079341379","https://openalex.org/W2094498138","https://openalex.org/W2104379615","https://openalex.org/W2133597849","https://openalex.org/W2142774659","https://openalex.org/W2202853636","https://openalex.org/W2300652355","https://openalex.org/W2395202427","https://openalex.org/W2418242418","https://openalex.org/W2461372410","https://openalex.org/W2473839812"],"related_works":["https://openalex.org/W1520089673","https://openalex.org/W1985182460","https://openalex.org/W1581108601","https://openalex.org/W4313315120","https://openalex.org/W23775068","https://openalex.org/W2110807103","https://openalex.org/W2413163532","https://openalex.org/W1497404427","https://openalex.org/W2027806565","https://openalex.org/W7132078867"],"abstract_inverted_index":{"Immunoglobulin":[0],"(Ig)":[1],"secreting":[2],"cells":[3,29,52,68,88,112,129],"occur":[4,113],"in":[5,48,55,74,89,102,114,132,140],"all":[6,66],"lymphoid":[7,105,117,146],"tissues,":[8,118],"including":[9],"the":[10,19,31,37,63,70,75,81,94,100,103,115,133,157,177],"bone":[11],"marrow":[12],"(BM).":[13],"There":[14],"are":[15,53,72,97,130],"important":[16],"differences":[17],"between":[18],"various":[20],"organs":[21],"with":[22],"respect":[23],"to":[24,80,172],"their":[25],"number":[26],"of":[27,36,65,69,83,86,93,165,170],"Ig-secreting":[28,51,67],"and":[30,57],"heavy":[32],"chain":[33],"isotype":[34],"distribution":[35,42],"secreted":[38],"Igs.":[39],"Furthermore,":[40],"both":[41],"patterns":[43],"depend":[44],"on":[45],"age.":[46],"Early":[47],"life":[49],"most":[50,110,127],"localized":[54,73,131],"spleen":[56],"lymph":[58],"nodes.":[59],"In":[60],"adults,":[61],"however,":[62],"majority":[64],"individual":[71],"BM.":[76,90,134],"Immunization":[77],"can":[78],"lead":[79],"appearance":[82],"substantial":[84],"numbers":[85],"antibody-forming":[87,111,128],"The":[91],"kinetics":[92],"BM":[95,158],"response":[96,101,159],"different":[98],"from":[99],"peripheral":[104,116,145],"tissues.":[106],"Shortly":[107],"after":[108],"immunization":[109],"but":[119,150,162],"later":[120],"on,":[121],"especially":[122],"during":[123],"secondary":[124],"type":[125],"responses,":[126],"Apparently,":[135],"antibody":[136],"formation":[137],"is":[138],"regulated":[139],"such":[141],"a":[142,153,166],"way":[143],"that":[144],"tissues":[147],"respond":[148],"rapidly,":[149],"only":[151],"for":[152],"short":[154],"period,":[155],"whereas":[156],"starts":[160],"slowly,":[161],"takes":[163],"care":[164],"long-lasting":[167],"massive":[168],"production":[169],"antibodies":[171],"antigens":[173],"which":[174],"repeatedly":[175],"challenge":[176],"organism.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}