{"id":"https://openalex.org/W758096833","doi":null,"title":"Sustained Negative BOLD and Blood Flow Response and its Coupling to the Positive Response in the Human Brain","display_name":"Sustained Negative BOLD and Blood Flow Response and its Coupling to the Positive Response in the Human Brain","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W758096833","mag":"758096833"},"language":"en","primary_location":{"id":"pmh:oai:pure.mpg.de:item_1792877","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-DFE6-A","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002)","raw_type":"info:eu-repo/semantics/other"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11858/00-001M-0000-0013-DFE6-A","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079077965","display_name":"Amir Shmuel","orcid":"https://orcid.org/0000-0003-3028-6639","observed_orcids":["https://orcid.org/0000-0003-3028-6639"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amir Shmuel","raw_affiliation_strings":["Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0003-3028-6639","affiliations":[{"raw_affiliation_string":"Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052167733","display_name":"Pfeuffer Yacoub E","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pfeuffer Yacoub E","raw_affiliation_strings":["Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035525811","display_name":"Adriany G Moortele P-Fvd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriany G Van de Moortele P-F","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032770951","display_name":"Xiaoping Philip Hu","orcid":"https://orcid.org/0000-0001-7014-5983","observed_orcids":["https://orcid.org/0000-0001-7014-5983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoping Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7014-5983","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/negative-bold-response","display_name":"negative BOLD response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.42899999022483826},{"id":"https://openalex.org/keywords/cerebral-blood-flow-reduction","display_name":"cerebral blood flow reduction","score":0.6740000247955322},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.4909999966621399},{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.48917892575263977},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.4863641858100891},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4710889756679535},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.445713073015213},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.4270809590816498},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4237411618232727},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.26893186569213867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26179784536361694},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.22267788648605347},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.1710663139820099},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11995494365692139},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.mpg.de:item_1792877","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-DFE6-A","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002)","raw_type":"info:eu-repo/semantics/other"},{"id":"mag:758096833","doi":null,"is_oa":false,"landing_page_url":"https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_1792877","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.mpg.de:item_1792877","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-DFE6-A","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002)","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2111177099","https://openalex.org/W7021240304","https://openalex.org/W1966123019","https://openalex.org/W847969089","https://openalex.org/W2103333652","https://openalex.org/W1980446678","https://openalex.org/W2892021257","https://openalex.org/W7011785782","https://openalex.org/W856790075","https://openalex.org/W2886454351"],"abstract_inverted_index":{"Most":[0],"fMRI":[1],"studies":[2,18,40],"are":[3],"based":[4],"on":[5],"the":[6,20,31,42,66,81,96,101],"detection":[7],"of":[8,22,33],"a":[9,85,89],"positive":[10,82],"BOLD":[11,55,70],"response":[12,56,71],"(PBR).":[13],"A":[14],"few":[15],"previous":[16],"human":[17,102],"indicated":[19],"existence":[21],"negatively":[23],"responding":[24],"voxels":[25],"in":[26,41,91,100],"brain":[27],"regions":[28,99],"remote":[29],"from":[30,65],"focus":[32],"PBR":[34,52],"(1,":[35],"2,":[36],"and":[37,46,53,77],"others).":[38],"Recent":[39],"anesthetized":[43],"cat":[44],"(3)":[45],"monkey":[47],"(4)":[48],"have":[49],"demonstrated":[50],"adjacent":[51],"negative":[54,69],"(NBR).":[57],"In":[58],"this":[59],"study":[60],"we":[61],"demonstrate":[62],"sustained":[63],"(different":[64],"\"initial":[67],"dip\")":[68],"(NBR)":[72],"that":[73,87],"occurs":[74],"concurrently":[75],"with":[76],"is":[78],"coupled":[79],"to":[80,95],"response,":[83],"via":[84],"mechanism":[86],"involves":[88],"reduction":[90],"blood":[92],"flow":[93],"(CBF)":[94],"less":[97],"demanding":[98],"brain.":[103]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}