{"id":"https://openalex.org/W75804495","doi":"https://doi.org/10.1023/a:1016309010784","title":"Influence of Volume Shift in Equilibrium Dialysis to Estimate Plasma Protein Binding of Drugs","display_name":"Influence of Volume Shift in Equilibrium Dialysis to Estimate Plasma Protein Binding of Drugs","publication_year":1984,"publication_date":"1984-07-01","ids":{"openalex":"https://openalex.org/W75804495","doi":"https://doi.org/10.1023/a:1016309010784","mag":"75804495","pmid":"https://pubmed.ncbi.nlm.nih.gov/24277291"},"language":"en","primary_location":{"id":"doi:10.1023/a:1016309010784","doi":"https://doi.org/10.1023/a:1016309010784","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1016309010784","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110249086","display_name":"Joseph J. H. M. Lohman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133559","display_name":"Zuyderland Medisch Centrum","ror":"https://ror.org/03bfc4534","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210133559","https://openalex.org/I4210166163"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joseph J. H. M. Lohman","raw_affiliation_strings":["Department of Clinical Pharmacy, Hospital Sittard, Sittard, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Hospital Sittard, Sittard, The Netherlands","institution_ids":["https://openalex.org/I4210133559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008894367","display_name":"Piet M. Hooymans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133559","display_name":"Zuyderland Medisch Centrum","ror":"https://ror.org/03bfc4534","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210133559","https://openalex.org/I4210166163"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Piet M. Hooymans","raw_affiliation_strings":["Department of Clinical Pharmacy, Hospital Sittard, Sittard, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Hospital Sittard, Sittard, The Netherlands","institution_ids":["https://openalex.org/I4210133559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075215432","display_name":"M. T. J. M. Verhey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maurice T. J. M. Verhey","raw_affiliation_strings":["Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024926198","display_name":"M. L. P. Koten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marli L. P. Koten","raw_affiliation_strings":["Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030750015","display_name":"Frans W. H. M. Merkus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133559","display_name":"Zuyderland Medisch Centrum","ror":"https://ror.org/03bfc4534","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210133559","https://openalex.org/I4210166163"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frans W. H. M. Merkus","raw_affiliation_strings":["Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands","Department of Clinical Pharmacy, Hospital Sittard, Sittard, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, Hospital Sittard, Sittard, The Netherlands","institution_ids":["https://openalex.org/I4210133559"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.2958,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.46778657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"4","first_page":"187","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-binding","display_name":"drug binding","score":0.597000002861023},{"id":"https://openalex.org/keywords/equilibrium-dialysis","display_name":"equilibrium dialysis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/protein-binding-assay","display_name":"protein binding assay","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5379870533943176},{"id":"https://openalex.org/C2991747820","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Plasma volume","level":2,"score":0.5345299243927002},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.5029005408287048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.495821088552475},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4718893766403198},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37611567974090576},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3357478380203247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27637404203414917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25531211495399475},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.23111137747764587},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17748579382896423},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07952427864074707}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1016309010784","doi":"https://doi.org/10.1023/a:1016309010784","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1016309010784","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:24277291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24277291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W35884303","https://openalex.org/W1972387119","https://openalex.org/W2043918567","https://openalex.org/W2055249519"],"related_works":["https://openalex.org/W2055249519","https://openalex.org/W1989638885","https://openalex.org/W2088755752","https://openalex.org/W134356439","https://openalex.org/W4396875389","https://openalex.org/W2062632363","https://openalex.org/W1986070700","https://openalex.org/W2022559430","https://openalex.org/W3203529433","https://openalex.org/W798758139"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}