{"id":"https://openalex.org/W75729901","doi":null,"title":"Intrinsically Disordered Proteins in Human Diseases.","display_name":"Intrinsically Disordered Proteins in Human Diseases.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W75729901","mag":"75729901"},"language":"en","primary_location":{"id":"mag:75729901","doi":null,"is_oa":false,"landing_page_url":"https://dblp.uni-trier.de/db/conf/bibe/bibe2007.html#UverskyOD07","pdf_url":null,"source":{"id":"https://openalex.org/S4306417835","display_name":"Bioinformatics and Bioengineering","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics and Bioengineering","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["Indiana Univ.-Purdue Univ. Indianapolis"],"raw_orcid":"https://orcid.org/0000-0002-4037-5857","affiliations":[{"raw_affiliation_string":"Indiana Univ.-Purdue Univ. Indianapolis","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091785779","display_name":"Christopher J. Oldfield","orcid":"https://orcid.org/0000-0002-3362-2047","observed_orcids":["https://orcid.org/0000-0002-3362-2047"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Oldfield","raw_affiliation_strings":["Indiana Univ.-Purdue Univ. Indianapolis"],"raw_orcid":"https://orcid.org/0000-0002-3362-2047","affiliations":[{"raw_affiliation_string":"Indiana Univ.-Purdue Univ. Indianapolis","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017746551","display_name":"A. Keith Dunker","orcid":"https://orcid.org/0000-0002-0744-5243","observed_orcids":["https://orcid.org/0000-0002-0744-5243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Keith Dunker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1088,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40768831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"12","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-intrinsic-disorder","display_name":"protein disorder","score":0.5410000085830688},{"id":"https://openalex.org/keywords/disease-associated-proteins","display_name":"disease-associated proteins","score":0.7020000219345093},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protein-conformational-diseases","display_name":"protein conformational diseases","score":0.6899999976158142},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.6549999713897705},{"id":"https://openalex.org/keywords/signaling-proteins","display_name":"signaling proteins","score":0.5419999957084656},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.49300000071525574},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.5440000295639038},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.828000009059906},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6110000014305115},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7049999833106995},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.968999981880188},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9860000014305115},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.9756141901016235},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5193096995353699},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4805867671966553},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4363614320755005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4045501947402954},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39756786823272705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34882861375808716},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.30962640047073364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2837788760662079},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18292516469955444},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11886489391326904},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0843941867351532},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:75729901","doi":null,"is_oa":false,"landing_page_url":"https://dblp.uni-trier.de/db/conf/bibe/bibe2007.html#UverskyOD07","pdf_url":null,"source":{"id":"https://openalex.org/S4306417835","display_name":"Bioinformatics and Bioengineering","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics and Bioengineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2189542288","https://openalex.org/W2008981210","https://openalex.org/W2832115545","https://openalex.org/W4239459599","https://openalex.org/W2118608964","https://openalex.org/W2736988026","https://openalex.org/W7058473169","https://openalex.org/W2015158057","https://openalex.org/W2110790611","https://openalex.org/W2022287303"],"abstract_inverted_index":{"Intrinsically":[0,174,323],"disordered":[1,42,48,61,108,123,135,141,162,175,199,237,324,357,527],"proteins":[2,24,33,39,49,62,124,163,176,200,219,238,267,281,338,451],"lack":[3],"stable":[4],"tertiary":[5],"and/or":[6],"secondary":[7],"structure":[8,456],"under":[9],"physiological":[10],"conditions":[11],"in":[12,18,65,170,180,367,385,403,461],"vitro.":[13],"They":[14],"are":[15,63,177,239,263,353,458],"highly":[16,185],"abundant":[17,186],"nature,":[19],"with":[20,29,95,105,241,266,286,364,399],"~25-30%":[21],"of":[22,31,37,46,56,88,121,134,155,191,212,288,378,388,395,411,416,473,479,493,519,525],"eukaryotic":[23,32],"being":[25,184],"mostly":[26],"disordered,":[27],"and":[28,34,53,68,76,110,142,159,215,224,253,301,321,333,382,390,398,407,457,487,489,517],">50%":[30],">":[35],"70%":[36],"signaling":[38,67,300],"having":[40],"long":[41,106],"regions.":[43],"Functional":[44],"repertoire":[45],"intrinsically":[47,60,107,122,161,236,356,526],"is":[50,117,150,292,465],"very":[51],"broad":[52,362],"complements":[54],"functions":[55,120],"ordered":[57,143],"proteins.":[58,209,358,528],"Often,":[59],"involved":[64,460],"regulation,":[66],"control":[69],"pathways,":[70],"where":[71],"binding":[72],"to":[73,168,220,269,273,282,428,436,482,505],"multiple":[74],"partners":[75],"high-specificity/low-affinity":[77],"interactions":[78],"play":[79],"a":[80,171,226,374,383,491],"crucial":[81],"role.":[82],"We":[83],"have":[84,454],"found":[85,446],"that":[86,119,259,306,447],"out":[87],"the":[89,128,153,156,497,515,523],"711":[90],"Swiss-Prot":[91],"functional":[92],"keywords":[93],"associated":[94,240,280],"at":[96],"least":[97],"20":[98],"proteins,":[99,325,476],"262":[100],"were":[101,112],"strongly":[102,113,264,284],"positively":[103],"correlated":[104,265,285],"regions,":[109],"302":[111],"negatively":[114],"correlated.":[115],"It":[116],"suggested":[118],"may":[125,310],"arise":[126],"from":[127,132,138,314,319],"specific":[129],"disorder":[130,217],"form,":[131],"inter-conversion":[133],"forms,":[136],"or":[137],"transitions":[139],"between":[140,147,296],"conformations.":[144],"The":[145],"choice":[146],"these":[148],"conformations":[149],"determined":[151],"by":[152],"peculiarities":[154],"protein":[157,232,307,315,430,438,442,484,494],"environment,":[158],"many":[160,260,334,448],"possess":[164],"an":[165,293,365],"exceptional":[166],"ability":[167],"fold":[169],"templatedependent":[172],"manner.":[173],"key":[178],"players":[179],"protein-protein":[181,345],"interaction":[182,233],"networks":[183],"among":[187],"hubs.":[188],"Furthermore,":[189],"regions":[190],"mRNA":[192],"which":[193,304],"undergo":[194],"alternative":[195,213],"splicing":[196,214],"code":[197,206],"for":[198,207,229,342,350,467,477,490,522],"much":[201],"more":[202,508],"often":[203,459],"than":[204],"they":[205],"structured":[208],"This":[210],"association":[211],"intrinsic":[216,297],"helps":[218],"avoid":[221],"folding":[222],"difficulties":[223],"provides":[225],"novel":[227,348,480],"mechanism":[228],"developing":[230],"tissue-specific":[231],"networks.":[234],"Numerous":[235],"such":[242,326],"human":[243,261,302,462],"diseases":[244,262,309],"as":[245,327],"cancer,":[246],"cardiovascular":[247],"disease,":[248],"amyloidoses,":[249],"neurodegenerative":[250],"diseases,":[251,303],"diabetes":[252],"others.":[254],"Our":[255],"bioinformatics":[256,520],"analysis":[257],"revealed":[258],"predicted":[268],"be":[270,283],"disordered.":[271],"Contrary":[272],"this,":[274],"we":[275],"did":[276],"not":[277,312,453],"find":[278],"disease":[279],"absence":[287],"disorder.":[289],"Overall,":[290],"there":[291],"intriguing":[294],"interconnection":[295],"disorder,":[298],"cell":[299],"suggests":[305],"conformational":[308],"result":[311],"only":[313],"misfolding,":[316],"but":[317],"also":[318],"misidentification":[320],"missignaling.":[322],"\u03b1-synuclein,":[328],"tau":[329],"protein,":[330],"p53,":[331],"BRCA1":[332],"other":[335],"disease-associated":[336],"hub":[337],"represent":[339],"attractive":[340],"targets":[341],"drugs":[343],"modulating":[344],"interactions.":[346],"Therefore,":[347],"strategies":[349],"drug":[351],"discovery":[352],"based":[354],"on":[355,441,470,514],"Dr.":[359,422,444,510],"Uversky":[360,423,445,511],"received":[361],"training,":[363],"MS":[366],"Physics":[368],"(Leningrad":[369],"State":[370],"University,":[371],"Russia,":[372],"1986),":[373],"PhD":[375],"(Moscow":[376],"Institute":[377,410],"Technical":[379],"Physics,":[380],"1991)":[381],"DSc":[384],"Biophysics":[386,408],"(Institute":[387],"Experimental":[389],"Theoretical":[391],"Biophysics,":[392],"Russian":[393,414],"Academy":[394,415],"Sciences,":[396],"1998)":[397],"preand":[400],"postdoctoral":[401],"research":[402],"Structural":[404],"Biology,":[405],"Biochemistry":[406],"(1991-1998,":[409],"Protein":[412],"Research,":[413],"Sciences).":[417],"From":[418],"1985":[419],"until":[420],"1998,":[421,433],"used":[424],"molecular":[425],"biophysics":[426],"methods":[427,521],"study":[429,483,524],"folding.":[431],"In":[432],"he":[434,503],"started":[435],"investigate":[437],"misfolding.":[439],"Working":[440],"foldingmisfolding,":[443],"biologically":[449],"active":[450],"do":[452],"rigid":[455],"diseases.":[463],"He":[464],"known":[466],"his":[468],"work":[469],"structural":[471],"characterization":[472],"partially":[474],"folded":[475],"development":[478,516],"tools":[481],"folding,":[485],"misfolding":[486],"nonfolding,":[488],"model":[492],"amyloidogenesis":[495],"involving":[496],"pre-molten":[498],"globular":[499],"(disordered)":[500],"state.":[501],"While":[502],"continues":[504],"use":[506,518],"biophysics,":[507],"recently":[509],"has":[512],"focused":[513]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
