{"id":"https://openalex.org/W7569769","doi":null,"title":"Pharmacokinetics and bioavailability of tamoxifen in postmenopausal healthy women.","display_name":"Pharmacokinetics and bioavailability of tamoxifen in postmenopausal healthy women.","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W7569769","mag":"7569769","pmid":"https://pubmed.ncbi.nlm.nih.gov/8740091"},"language":"en","primary_location":{"id":"pmid:8740091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8740091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028117082","display_name":"W S Fuchs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W S Fuchs","raw_affiliation_strings":["Klinge Pharma GmbHa, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinge Pharma GmbHa, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114005664","display_name":"W P Leary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Leary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076102630","display_name":"M J van der Meer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J van der Meer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029329633","display_name":"Steffen Gay","orcid":"https://orcid.org/0000-0002-2920-9268","observed_orcids":["https://orcid.org/0000-0002-2920-9268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Gay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064754583","display_name":"K Witschital","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Witschital","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111952400","display_name":"A von Nieciecki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A von Nieciecki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1067,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.3516921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"4","first_page":"418","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.9120000004768372},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9729999899864197},{"id":"https://openalex.org/keywords/n-desmethyltamoxifen","display_name":"N-desmethyltamoxifen","score":0.9559999704360962},{"id":"https://openalex.org/keywords/bioactive-metabolites","display_name":"bioactive metabolites","score":0.7329999804496765},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.875},{"id":"https://openalex.org/keywords/crossover-design","display_name":"crossover design","score":0.824999988079071},{"id":"https://openalex.org/keywords/breast-cancer-treatment","display_name":"breast cancer treatment","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.8570523262023926},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7928748726844788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6205425262451172},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.575440526008606},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5263063907623291},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.5075379610061646},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.49906039237976074},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.46522781252861023},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.45014670491218567},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44228383898735046},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.4226624071598053},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4178580641746521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4096132516860962},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16533169150352478},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013810","descriptor_name":"Therapeutic Equivalency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8740091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8740091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},{"id":"mag:7569769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8740091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W273394518","https://openalex.org/W398084223","https://openalex.org/W1517020408","https://openalex.org/W1517625197","https://openalex.org/W1593868340","https://openalex.org/W1903395966","https://openalex.org/W1967183207","https://openalex.org/W1968211769","https://openalex.org/W1972150732","https://openalex.org/W1975183414","https://openalex.org/W1975421951","https://openalex.org/W1988828528","https://openalex.org/W1998176243","https://openalex.org/W2003881446","https://openalex.org/W2008754980","https://openalex.org/W2012343531","https://openalex.org/W2012601253","https://openalex.org/W2017570609","https://openalex.org/W2041468487","https://openalex.org/W2052731507","https://openalex.org/W2083588872","https://openalex.org/W2086173758","https://openalex.org/W2087471419","https://openalex.org/W2108309364","https://openalex.org/W2129031038","https://openalex.org/W2133889010","https://openalex.org/W2141260882","https://openalex.org/W2176061808","https://openalex.org/W2207636415","https://openalex.org/W4248512491"],"related_works":["https://openalex.org/W2418977381","https://openalex.org/W2375912215","https://openalex.org/W62864937","https://openalex.org/W2425585559","https://openalex.org/W2358058619","https://openalex.org/W2364103166","https://openalex.org/W2416188365","https://openalex.org/W2331295679","https://openalex.org/W2007340909","https://openalex.org/W1984449703"],"abstract_inverted_index":{"A":[0],"randomised":[1],"cross-over":[2,218],"study":[3,22,157],"in":[4,32,155,160,194],"24":[5],"postmenopausal":[6,33,173,195],"women":[7,196],"was":[8,88],"selected":[9],"to":[10],"establish":[11],"bioequivalence":[12],"of":[13,38,44,69,86,107,114,134,191,216],"two":[14],"tamoxifen":[15,39,72,87],"(CAS":[16],"10540-29-1)":[17],"formulations.":[18],"In":[19],"addition,":[20],"this":[21,156],"compiled":[23],"pharmacokinetic":[24,152,165],"parameters":[25,153],"for":[26,73,224],"the":[27,35,74,78,108,115,135,210,214],"current":[28],"30":[29,70],"mg":[30,71],"regimen":[31],"women,":[34],"target":[36],"population":[37],"therapy.":[40],"Mean":[41],"Cmax":[42],"values":[43],"59.1":[45],"+/-":[46,58,63,92,97,120,125,142,147,199,204],"8.9":[47],"(T)":[48,60,76,94,122,144,201],"and":[49,61,77,95,123,145,172,180,202,222],"63.6":[50],"+/0":[51],"11.1":[52],"(R)":[53,65,80,99,127,149,206],"ng/ml":[54],"were":[55,137],"attained":[56],"3.6":[57],"1.2":[59],"3.2":[62],"1.1":[64],"h":[66],"after":[67],"administration":[68],"test":[75],"reference":[79],"formulation.":[81],"The":[82,103,151],"mean":[83],"AUC":[84,105],"(0-480)":[85,106],"calculated":[89],"as":[90],"3299.7":[91],"761.2":[93],"3370.1":[96],"701.9":[98],"ng":[100,128],"x":[101,129],"h/ml.":[102],"corresponding":[104],"active":[109],"metabolite,":[110],"N-desmethyl-tamoxifen,":[111],"exceeded":[112],"that":[113],"parent":[116],"drug":[117],"with":[118,140,162,168,175,197],"4359.7":[119],"830.5":[121],"4306.3":[124],"835.2":[126],"h/ml,":[130],"whereas":[131],"maximal":[132],"concentrations":[133],"metabolite":[136],"distinctly":[138],"decreased":[139],"14.4":[141],"3.3":[143],"14.3":[146],"2.4":[148],"ng/ml.":[150],"evaluated":[154],"are":[158],"well":[159],"line":[161],"already":[163],"known":[164],"data":[166],"generated":[167],"young":[169],"male":[170],"volunteers":[171],"patients":[174],"breast":[176],"cancer.":[177],"Precise":[178],"analytics":[179],"an":[181,188],"extremely":[182,211],"long":[183,212],"blood":[184],"sampling":[185],"period":[186],"facilitated":[187],"accurate":[189],"determination":[190],"tamoxifen's":[192],"half-life":[193],"210.1":[198],"60.8":[200],"209.8":[203],"59.9":[205],"h.":[207],"Based":[208],"on":[209],"half-life,":[213],"suitability":[215],"a":[217],"design":[219],"is":[220],"discussed":[221],"recommended":[223],"further":[225],"studies.":[226]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}