{"id":"https://openalex.org/W7569274","doi":null,"title":"Exercise and neuroplasticity in persons living with Parkinson's disease.","display_name":"Exercise and neuroplasticity in persons living with Parkinson's disease.","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W7569274","mag":"7569274","pmid":"https://pubmed.ncbi.nlm.nih.gov/19532109"},"language":"en","primary_location":{"id":"pmid:19532109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19532109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of physical and rehabilitation medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043976835","display_name":"Mark A. Hirsch","orcid":"https://orcid.org/0000-0002-8997-7971","observed_orcids":["https://orcid.org/0000-0002-8997-7971"]},"institutions":[{"id":"https://openalex.org/I1334069289","display_name":"Carolinas Healthcare System","ror":"https://ror.org/0594s0e67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334069289"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Hirsch","raw_affiliation_strings":["Carolinas Rehabilitation, Department of Physical Medicine and Rehabilitation, Charlotte, North Carolina 28203, USA. mark.hirsch@carolinashealthcare.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolinas Rehabilitation, Department of Physical Medicine and Rehabilitation, Charlotte, North Carolina 28203, USA. mark.hirsch@carolinashealthcare.org","institution_ids":["https://openalex.org/I1334069289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040911828","display_name":"Becky G. Farley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B G Farley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.1127,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.98036364,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"45","issue":"2","first_page":"215","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.921999990940094},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neurorestoration","display_name":"neurorestoration","score":0.7929999828338623},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.9190000295639038},{"id":"https://openalex.org/keywords/non-pharmacological-rehabilitation","display_name":"non-pharmacological rehabilitation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"physiotherapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6430000066757202},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8174034357070923},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.6489940285682678},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.635718584060669},{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.5696167349815369},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5693724155426025},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.5563406944274902},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5370638966560364},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.5146521329879761},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5065895318984985},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49333372712135315},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.4820305109024048},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.39915984869003296},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.32279717922210693},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14715233445167542},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12054300308227539},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10787132382392883},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19532109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19532109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of physical and rehabilitation medicine","raw_type":"Journal Article"},{"id":"mag:7569274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19532109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408766520","https://openalex.org/W3010441317","https://openalex.org/W2318401945","https://openalex.org/W4387501017","https://openalex.org/W2570417704","https://openalex.org/W2106781761","https://openalex.org/W2004135876","https://openalex.org/W4376132293","https://openalex.org/W2323648650","https://openalex.org/W1923518481"],"abstract_inverted_index":{"For":[0],"many":[1,99],"years,":[2],"exercise":[3,25,57,207],"was":[4,22,39],"not":[5],"a":[6,13,61,180],"recommended":[7],"rehabilitation":[8],"strategy":[9],"for":[10,190],"persons":[11],"with":[12],"diagnosis":[14],"of":[15,46,69,81,90,96,105,123,151,159,186,206,213],"idiopathic":[16],"Parkinson's":[17],"disease":[18,153],"(PD).":[19],"Since":[20],"it":[21,38],"believed":[23],"that":[24,134],"had":[26],"no":[27],"measurable":[28],"effect":[29,64],"on":[30,65],"PD,":[31],"or":[32,58,113,147,154],"might":[33],"worsen":[34],"the":[35,66,87,94,106,149,152,184,194,204,211,214],"underlying":[36,109],"pathology,":[37],"to":[40,85,196,202,210],"be":[41,193],"avoided.":[42],"A":[43],"rich":[44],"vein":[45],"bench":[47],"and":[48,101,116,143,167,208],"translational":[49],"research":[50],"now":[51],"suggest":[52],"non-pharmacological":[53],"approaches,":[54],"such":[55],"as":[56],"physiotherapy,":[59],"have":[60,83],"far":[62],"greater":[63],"cardinal":[67],"features":[68],"PD":[70,82,191,209],"than":[71],"previously":[72],"believed.":[73],"In":[74],"particular,":[75],"recent":[76],"studies":[77,132],"utilizing":[78],"animal":[79,121],"models":[80,122],"begun":[84],"explore":[86],"molecular":[88],"mechanisms":[89],"exercise-induced":[91,110],"changes":[92],"in":[93,120,173,183],"pathophysiology":[95],"PD.":[97,124],"Yet,":[98],"clinicians":[100],"communities":[102],"remain":[103],"unaware":[104],"scientific":[107],"literature":[108],"brain":[111],"repair":[112],"reorganization":[114],"(neuroplasticity)":[115],"accompanying":[117],"behavioral":[118],"recovery":[119],"The":[125],"authors":[126],"will":[127,192],"summarize":[128],"some":[129],"noteworthy":[130],"preliminary":[131,169],"suggesting":[133],"continuous,":[135],"deficit":[136],"targeted,":[137],"intensive":[138],"training":[139],"may":[140],"confer":[141],"neuroprotection":[142],"thereby,":[144],"slow,":[145],"stop":[146],"reverse":[148],"progression":[150],"promote":[155],"neurorestoration":[156],"through":[157],"adaptation":[158],"compromised":[160],"signaling":[161],"pathways.":[162],"While":[163],"much":[164],"work":[165],"remains":[166],"these":[168],"results":[170],"await":[171],"replication":[172],"larger":[174],"prospective":[175],"human":[176],"trials,":[177],"we":[178],"believe":[179],"major":[181],"challenge":[182],"field":[185],"non-pharmacological,":[187],"rehabilitative":[188],"intervention":[189],"extent":[195],"which":[197],"healthcare":[198],"providers":[199],"are":[200],"able":[201],"translate":[203],"science":[205],"level":[212],"community.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}