{"id":"https://openalex.org/W756598331","doi":"https://doi.org/10.1016/j.bmcl.2015.05.044","title":"Synthesis and evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as antimycobacterial agents","display_name":"Synthesis and evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as antimycobacterial agents","publication_year":2015,"publication_date":"2015-05-26","ids":{"openalex":"https://openalex.org/W756598331","doi":"https://doi.org/10.1016/j.bmcl.2015.05.044","mag":"756598331","pmid":"https://pubmed.ncbi.nlm.nih.gov/26048808"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2015.05.044","doi":"https://doi.org/10.1016/j.bmcl.2015.05.044","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2015.05.044","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025283430","display_name":"Narender Reddy Emmadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narender Reddy Emmadi","raw_affiliation_strings":["Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024790075","display_name":"Chiranjeevi Bingi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chiranjeevi Bingi","raw_affiliation_strings":["Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055274751","display_name":"Sudha Sravanti Kotapalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudha Sravanti Kotapalli","raw_affiliation_strings":["Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077068037","display_name":"Ramesh Ummanni","orcid":"https://orcid.org/0000-0003-1123-282X","observed_orcids":["https://orcid.org/0000-0003-1123-282X"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramesh Ummanni","raw_affiliation_strings":["Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005818828","display_name":"Jagadeesh Babu Nanubolu","orcid":"https://orcid.org/0000-0002-1677-2975","observed_orcids":["https://orcid.org/0000-0002-1677-2975"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jagadeesh Babu Nanubolu","raw_affiliation_strings":["Centre for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001485684","display_name":"Krishnaiah Atmakur","orcid":"https://orcid.org/0000-0002-0076-513X","observed_orcids":["https://orcid.org/0000-0002-0076-513X"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Krishnaiah Atmakur","raw_affiliation_strings":["Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: krishnu@iict.res.in","Academy of Scientific and Innovative Research, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, India","Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology,Hyderabad 500007,India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: krishnu@iict.res.in","institution_ids":["https://openalex.org/I55664587"]},{"raw_affiliation_string":"Academy of Scientific and Innovative Research, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, India","institution_ids":["https://openalex.org/I55664587","https://openalex.org/I99364266"]},{"raw_affiliation_string":"Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology,Hyderabad 500007,India","institution_ids":["https://openalex.org/I55664587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001485684"],"corresponding_institution_ids":["https://openalex.org/I55664587","https://openalex.org/I99364266"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":3.6728,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93444015,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"15","first_page":"2918","last_page":"2922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.06809999793767929,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorinated-heterocycles","display_name":"fluorinated heterocycles","score":0.7580000162124634},{"id":"https://openalex.org/keywords/antimycobacterial-agents","display_name":"antimycobacterial agents","score":0.8370000123977661},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C2779685592","wikidata":"https://www.wikidata.org/wiki/Q2853298","display_name":"Antimycobacterial","level":4,"score":0.9234390258789062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8568919897079468},{"id":"https://openalex.org/C2776442012","wikidata":"https://www.wikidata.org/wiki/Q2302144","display_name":"Trifluoromethyl","level":3,"score":0.8314338326454163},{"id":"https://openalex.org/C2776730177","wikidata":"https://www.wikidata.org/wiki/Q421721","display_name":"Acetamide","level":2,"score":0.7976243495941162},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7346323728561401},{"id":"https://openalex.org/C2777907353","wikidata":"https://www.wikidata.org/wiki/Q903341","display_name":"Triazole","level":2,"score":0.6683739423751831},{"id":"https://openalex.org/C2781002465","wikidata":"https://www.wikidata.org/wiki/Q161297","display_name":"1,2,3-Triazole","level":2,"score":0.5987741947174072},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5566059947013855},{"id":"https://openalex.org/C2777162773","wikidata":"https://www.wikidata.org/wiki/Q2013529","display_name":"Quinazolinone","level":2,"score":0.4699815809726715},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.46934473514556885},{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.41338464617729187},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3459882438182831},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22528907656669617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09927394986152649},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.08072453737258911},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009165","descriptor_name":"Mycobacterium Infections, Nontuberculous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020102","descriptor_name":"Mycobacterium smegmatis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057930","descriptor_name":"Click Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2015.05.044","doi":"https://doi.org/10.1016/j.bmcl.2015.05.044","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2015.05.044","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:26048808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26048808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1893024652","https://openalex.org/W1968246596","https://openalex.org/W1977309046","https://openalex.org/W1977851521","https://openalex.org/W1978533750","https://openalex.org/W1981323635","https://openalex.org/W1981824586","https://openalex.org/W1982746475","https://openalex.org/W1988066093","https://openalex.org/W1989875852","https://openalex.org/W2009212060","https://openalex.org/W2011384588","https://openalex.org/W2020791813","https://openalex.org/W2022116685","https://openalex.org/W2046806300","https://openalex.org/W2054538980","https://openalex.org/W2055981208","https://openalex.org/W2068355085","https://openalex.org/W2072267373","https://openalex.org/W2077605453","https://openalex.org/W2080094366","https://openalex.org/W2093788608","https://openalex.org/W2093830513","https://openalex.org/W2122395806","https://openalex.org/W2129378382","https://openalex.org/W2133369290","https://openalex.org/W2135887895","https://openalex.org/W2145662716","https://openalex.org/W2146496405","https://openalex.org/W2159773654","https://openalex.org/W2164499213","https://openalex.org/W2177833771","https://openalex.org/W2315479558","https://openalex.org/W2327031515","https://openalex.org/W2949427636","https://openalex.org/W2951493757","https://openalex.org/W2953312507","https://openalex.org/W2953343819","https://openalex.org/W4237342534"],"related_works":["https://openalex.org/W2087129251","https://openalex.org/W4223424131","https://openalex.org/W2170794826","https://openalex.org/W2749145276","https://openalex.org/W1065968067","https://openalex.org/W4412795422","https://openalex.org/W4386600155","https://openalex.org/W2047509928","https://openalex.org/W4401010767","https://openalex.org/W2744748458"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}