{"id":"https://openalex.org/W75631823","doi":null,"title":"Designing thiophene-based fluorescent probes for the study of neurodegenerative protein aggregation diseases : From test tube to in vivo experiments","display_name":"Designing thiophene-based fluorescent probes for the study of neurodegenerative protein aggregation diseases : From test tube to in vivo experiments","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W75631823","mag":"75631823"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-51731","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51731","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057210285","display_name":"Andreas \u00c5slund","orcid":"https://orcid.org/0000-0001-5222-9307","observed_orcids":["https://orcid.org/0000-0001-5222-9307"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andreas \u00c5slund","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5222-9307","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057210285"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloid-detection","display_name":"amyloid detection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.6930000185966492},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.6010000109672546},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.5440000295639038},{"id":"https://openalex.org/keywords/probe-design","display_name":"probe design","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.7532550692558289},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6992834806442261},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5705930590629578},{"id":"https://openalex.org/C2778987444","wikidata":"https://www.wikidata.org/wiki/Q25111397","display_name":"Aggregation-induced emission","level":3,"score":0.5570861101150513},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.49458810687065125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4820919334888458},{"id":"https://openalex.org/C3019336641","wikidata":"https://www.wikidata.org/wiki/Q55643886","display_name":"Fluorescent protein","level":4,"score":0.4442647695541382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4182262718677521},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.4137452244758606},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35956352949142456},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3550233542919159},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32530221343040466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3190585970878601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30789732933044434},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.23979327082633972},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22363293170928955},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19243395328521729},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1284199357032776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12428659200668335},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06983068585395813},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-51731","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:75631823","doi":null,"is_oa":false,"landing_page_url":"http://liu.diva-portal.org/smash/get/diva2:277179/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-51731","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W857238335","https://openalex.org/W1542575378","https://openalex.org/W1561445208","https://openalex.org/W1569515633","https://openalex.org/W1619710608","https://openalex.org/W1964576814","https://openalex.org/W1964666742","https://openalex.org/W1965867531","https://openalex.org/W1968906927","https://openalex.org/W1972078733","https://openalex.org/W1976214926","https://openalex.org/W1976575069","https://openalex.org/W1978890358","https://openalex.org/W1979643175","https://openalex.org/W1980947093","https://openalex.org/W1983968838","https://openalex.org/W1987847349","https://openalex.org/W1987849663","https://openalex.org/W1991531169","https://openalex.org/W1991644458","https://openalex.org/W1993297514","https://openalex.org/W1994902235","https://openalex.org/W1995247791","https://openalex.org/W1995809133","https://openalex.org/W1998088268","https://openalex.org/W2001682320","https://openalex.org/W2004664692","https://openalex.org/W2005045231","https://openalex.org/W2009418110","https://openalex.org/W2009604591","https://openalex.org/W2013679718","https://openalex.org/W2014610432","https://openalex.org/W2014705599","https://openalex.org/W2016698723","https://openalex.org/W2017260345","https://openalex.org/W2017457068","https://openalex.org/W2024122111","https://openalex.org/W2024424098","https://openalex.org/W2024619129","https://openalex.org/W2024668825","https://openalex.org/W2028544408","https://openalex.org/W2029203254","https://openalex.org/W2029989515","https://openalex.org/W2030420318","https://openalex.org/W2031111535","https://openalex.org/W2037664996","https://openalex.org/W2039069312","https://openalex.org/W2044182870","https://openalex.org/W2045978439","https://openalex.org/W2046914956","https://openalex.org/W2047012360","https://openalex.org/W2050567117","https://openalex.org/W2051770221","https://openalex.org/W2056666485","https://openalex.org/W2056877984","https://openalex.org/W2058573142","https://openalex.org/W2059998218","https://openalex.org/W2060495639","https://openalex.org/W2063301167","https://openalex.org/W2064722614","https://openalex.org/W2067214887","https://openalex.org/W2067226609","https://openalex.org/W2069428582","https://openalex.org/W2074289268","https://openalex.org/W2077118428","https://openalex.org/W2077577457","https://openalex.org/W2078212921","https://openalex.org/W2091872511","https://openalex.org/W2092253109","https://openalex.org/W2092435564","https://openalex.org/W2092763153","https://openalex.org/W2093575909","https://openalex.org/W2093861673","https://openalex.org/W2095556304","https://openalex.org/W2095983586","https://openalex.org/W2097965815","https://openalex.org/W2098226300","https://openalex.org/W2102467345","https://openalex.org/W2103298870","https://openalex.org/W2108217811","https://openalex.org/W2109222288","https://openalex.org/W2111048594","https://openalex.org/W2113631794","https://openalex.org/W2117959132","https://openalex.org/W2119688276","https://openalex.org/W2121753059","https://openalex.org/W2121963977","https://openalex.org/W2122096623","https://openalex.org/W2129324258","https://openalex.org/W2130393399","https://openalex.org/W2137328098","https://openalex.org/W2142337553","https://openalex.org/W2156193029","https://openalex.org/W2157680389","https://openalex.org/W2158269342","https://openalex.org/W2161163255","https://openalex.org/W2163210644","https://openalex.org/W2163226209","https://openalex.org/W2166892529","https://openalex.org/W2952187839","https://openalex.org/W7098949224"],"related_works":["https://openalex.org/W4226336812","https://openalex.org/W4300026921","https://openalex.org/W3044256063","https://openalex.org/W2068928469","https://openalex.org/W3015207204","https://openalex.org/W4290805917","https://openalex.org/W2024424098","https://openalex.org/W2974219443","https://openalex.org/W4323653021","https://openalex.org/W4401639432"],"abstract_inverted_index":{"Protein":[0],"aggregation":[1],"is":[2,19,93],"an":[3,41],"event":[4],"related":[5],"to":[6,22,63,145],"numerous":[7],"neurodegenerative":[8],"diseases,":[9],"such":[10],"as":[11,21],"Alzhemier\u2019s":[12],"disease":[13],"and":[14,24,29,71,97,121,158,160],"prion":[15],"diseases.":[16],"However":[17],"little":[18],"known":[20],"how":[23],"why":[25],"the":[26,31,37,72,84,107,131,134,153,166],"aggregates":[27,164],"form":[28],"furthermore,":[30],"toxic":[32],"specie":[33,47],"may":[34,59],"not":[35,102],"be":[36],"mature":[38,49],"fibril":[39],"but":[40],"on":[42],"route":[43,46],"or":[44],"off":[45],"towards":[48],"aggregates.":[50],"During":[51],"this":[52],"project":[53],"molecular":[54],"probes":[55,67,137,142],"were":[56,126,138,143],"synthesized":[57],"that":[58,83],"shed":[60],"some":[61],"light":[62],"these":[64],"questions.":[65],"The":[66],"are":[68],"thiophene":[69,87,115],"based":[70,88,116],"technique":[73,92],"used":[74],"for":[75],"detection":[76],"was":[77,81],"mainly":[78],"fluorescence.":[79],"It":[80],"shown":[82,144],"previously":[85],"established":[86],"in":[89,98,119,165],"vitro":[90,120],"staining":[91,124],"valid":[94],"ex":[95,122],"vivo":[96,123],"vivo.":[99],"This":[100],"would":[101],"have":[103],"been":[104],"possible":[105],"without":[106],"synthesis":[108],"of":[109,112,133,150,168],"a":[110],"variety":[111],"functionalized":[113],"polymeric":[114],"probes;":[117],"their":[118],"properties":[125],"taken":[127],"into":[128],"consideration":[129],"when":[130],"design":[132],"small":[135],"oligomeric":[136],"decided":[139],"upon.":[140],"These":[141],"spectrally":[146],"distinguish":[147],"different":[148],"types":[149],"amyloid,":[151],"pass":[152],"bloodbrain":[154],"barrier":[155],"within":[156],"minutes":[157],"specifically":[159],"selectively":[161],"stain":[162],"protein":[163],"brains":[167],"mice.":[169]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}