{"id":"https://openalex.org/W755840193","doi":null,"title":"Progression of liver fibrosis in blood donors infected with hepatitis C virus.","display_name":"Progression of liver fibrosis in blood donors infected with hepatitis C virus.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W755840193","mag":"755840193","pmid":"https://pubmed.ncbi.nlm.nih.gov/15624026"},"language":"en","primary_location":{"id":"pmid:15624026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15624026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023154245","display_name":"Giovanni Faria Silva","orcid":"https://orcid.org/0000-0001-6129-7045","observed_orcids":["https://orcid.org/0000-0001-6129-7045"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giovanni Faria Silva","raw_affiliation_strings":["Department of Internal Medicine, Faculdade de Medicina de Botucatu, UNESP, 18618-000 Botucatu, Brazil. giovanni@botucatu.flash.tv.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculdade de Medicina de Botucatu, UNESP, 18618-000 Botucatu, Brazil. giovanni@botucatu.flash.tv.br","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974643","display_name":"Kunie Iabuki Rabello Coelho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunie Iabuki Rabello Coelho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109834","display_name":"Nancy Fusae Nishimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy F Nishimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017474794","display_name":"Elza Cotrim Soares","orcid":"https://orcid.org/0000-0001-6262-2997","observed_orcids":["https://orcid.org/0000-0001-6262-2997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elza Cotrim Soares","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1966,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60740872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"4","first_page":"291","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/liver-fibrosis-progression","display_name":"liver fibrosis progression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/blood-donors","display_name":"blood donors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.7630000114440918},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/metavir-score","display_name":"METAVIR score","score":0.8119999766349792},{"id":"https://openalex.org/keywords/age-at-infection","display_name":"age at infection","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alt","display_name":"ALT","score":0.5460000038146973},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.8460000157356262},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8947240114212036},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8504428863525391},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7031503319740295},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6963291168212891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6774592399597168},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.5286553502082825},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5235514044761658},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.48384061455726624},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48098599910736084},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4106595814228058},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.36325573921203613},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3016854226589203},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2695683538913727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:15624026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15624026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:acervodigital.unesp.br:11449/68035","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11449/68035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400256","display_name":"Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115194","host_organization_name":"Funda\u00e7\u00e3o para o Desenvolvimento da UNESP","host_organization_lineage":["https://openalex.org/I4210115194"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"outro"},{"id":"pmh:oai:repositorio.unesp.br:11449/68035","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11449/68035","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:755840193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15624026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161781098","https://openalex.org/W2374606271","https://openalex.org/W2132290252","https://openalex.org/W2028684272","https://openalex.org/W2122664567","https://openalex.org/W2462559095","https://openalex.org/W2001973858","https://openalex.org/W2127557833","https://openalex.org/W1594788864","https://openalex.org/W2483257947"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Chronic":[1],"hepatitis":[2],"by":[3,179],"HCV":[4],"is":[5,168,172],"progressive":[6],"towards":[7],"cirrhosis,":[8],"with":[9,23,45,47,77,145,174],"variable":[10],"rate.":[11],"We":[12,37],"evaluated":[13],"the":[14,31,113,125,135],"rate":[15],"of":[16,51,63,67,80,196],"fibrosis":[17,25,64,147,197],"progression":[18],"(RFP),":[19],"risk":[20],"factors":[21],"associated":[22,144],"advanced":[24,146],"(F3":[26,138],"and":[27,29,73,95,115,117,134,139,152,156,176,186,200],"F4),":[28],"estimated":[30],"evolution":[32,127],"time":[33],"to":[34,54,112,128],"cirrhosis.":[35],"METHODS:":[36],"transversely":[38],"selected":[39],"142":[40],"blood":[41],"donors":[42],"infected":[43],"only":[44],"HCV,":[46],"a":[48],"known":[49],"route":[50],"infection,":[52],"submitted":[53],"liver":[55],"biopsy":[56],"at":[57,110,158,184],"admission.":[58],"RFP=":[59],"ratio":[60],"between":[61,130],"stage":[62],"(METAVIR)/estimated":[65],"duration":[66],"infection":[68],"in":[69,124],"years.":[70],"Non-parametric":[71],"tests":[72],"logistic":[74],"regression":[75],"analysis,":[76],"significance":[78],"level":[79],"5%":[81],"were":[82,102,121,148],"used.":[83],"RESULTS:":[84],"Median":[85,99],"RFP":[86,100,167],"was":[87],"0.086":[88],"U/year":[89],"(0.05-0.142).":[90],"Ten":[91],"patients":[92,192],"had":[93,97,193],"F4":[94],"25":[96],"F3.":[98],"values":[101],"significantly":[103],"different":[104],"(p=0.001)":[105],"from":[106],"one":[107],"age":[108,157,183],"group":[109],"contamination":[111,185],"others":[114],"ALT":[116,149],"AST":[118],"levels.":[119],"There":[120],"no":[122],"differences":[123],"expected":[126],"cirrhosis":[129],"intermediate":[131],"fibrosers":[132,137],"(F2)":[133],"rapid":[136],"F4).":[140],"The":[141],"independent":[142],"variables":[143],"(OR":[150,154,160],"7.2)":[151],"GGT":[153],"6.4)":[155],"inclusion":[159],"1.12).":[161],"CONCLUSION:":[162],"This":[163],"study":[164],"suggests":[165],"that":[166],"extremely":[169],"variable,":[170],"it":[171],"exponential":[173],"age,":[175],"mainly":[177],"influenced":[178],"host":[180],"characteristics,":[181],"especially":[182],"possibly":[187],"ethnical":[188],"group.":[189],"These":[190],"asymptomatic":[191],"high":[194],"percentage":[195],"F2,":[198],"F3":[199],"F4.":[201]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}