{"id":"https://openalex.org/W75557213","doi":null,"title":"Metformine : le point sur les m\u00e9canismes d'action","display_name":"Metformine : le point sur les m\u00e9canismes d'action","publication_year":2012,"publication_date":"2012-03-03","ids":{"openalex":"https://openalex.org/W75557213","mag":"75557213"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:inserm-00683686v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/inserm-00683686v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Correspondances en M\u00e9tabolismes, Hormones, Diab\u00e8tes et Nutrition, 2012, XVI (3), pp.67-72","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/inserm-00683686v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045765280","display_name":"Beno\u00eet Viollet","orcid":"https://orcid.org/0000-0002-0121-0224","observed_orcids":["https://orcid.org/0000-0002-0121-0224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beno\u0131\u0302t Viollet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0121-0224","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043636167","display_name":"Marc Foretz","orcid":"https://orcid.org/0000-0001-7017-9032","observed_orcids":["https://orcid.org/0000-0001-7017-9032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Foretz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7017-9032","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081180378","display_name":"Fabrizio Andr\u00e9elli","orcid":"https://orcid.org/0000-0002-1207-3624","observed_orcids":["https://orcid.org/0000-0002-1207-3624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabrizio Andr\u00e9elli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1207-3624","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00518731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"XVI","issue":"3","first_page":"67","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.7649999856948853},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hepatic-gluconeogenesis","display_name":"hepatic gluconeogenesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain-inhibition","display_name":"mitochondrial respiratory chain inhibition","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8090000152587891},{"id":"https://openalex.org/keywords/energy-sensing","display_name":"energy sensing","score":0.7310000061988831},{"id":"https://openalex.org/keywords/macrovascular-complications","display_name":"macrovascular complications","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4554521441459656},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.362682580947876}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:inserm-00683686v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/inserm-00683686v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Correspondances en M\u00e9tabolismes, Hormones, Diab\u00e8tes et Nutrition, 2012, XVI (3), pp.67-72","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:75557213","doi":null,"is_oa":false,"landing_page_url":"https://www.hal.inserm.fr/inserm-00683686","pdf_url":null,"source":{"id":"https://openalex.org/S990175176","display_name":"Correspondances En Metabolismes Hormones Diabetes Et Nutrition","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Correspondances En Metabolismes Hormones Diabetes Et Nutrition","raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:inserm-00683686v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/inserm-00683686v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Correspondances en M\u00e9tabolismes, Hormones, Diab\u00e8tes et Nutrition, 2012, XVI (3), pp.67-72","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1521352086","https://openalex.org/W1966706887","https://openalex.org/W1997003352","https://openalex.org/W2015582203","https://openalex.org/W2028615902","https://openalex.org/W2042871909","https://openalex.org/W2072307303","https://openalex.org/W2092340120","https://openalex.org/W2123472586","https://openalex.org/W2138226825","https://openalex.org/W2138541689","https://openalex.org/W2144661518","https://openalex.org/W2151569537","https://openalex.org/W2154024784","https://openalex.org/W2156029342","https://openalex.org/W2158822657","https://openalex.org/W2162897961"],"related_works":["https://openalex.org/W2153266262","https://openalex.org/W2141324596","https://openalex.org/W2149407007","https://openalex.org/W7216924549","https://openalex.org/W2084784711","https://openalex.org/W7215650811","https://openalex.org/W7115985729","https://openalex.org/W2122007756","https://openalex.org/W2094901206","https://openalex.org/W4416442218"],"abstract_inverted_index":{">>":[0,17,48,76,95],"la":[1,21,27,34,51,57,64,72,89,93,101],"metformine":[2,22,58,94,102],"est":[3,13,59],"un":[4],"antidiab\u00e9tique":[5],"oral":[6],"de":[7,20,26,33,37,45,50,54,63,71,88,97,105,115],"r\u00e9f\u00e9rence":[8],"dont":[9],"le":[10],"mode":[11],"d'action":[12],"rest\u00e9":[14],"longtemps":[15],"impr\u00e9cis":[16],"l'effet":[18],"hypoglyc\u00e9miant":[19],"r\u00e9sulte":[23],"d'une":[24],"r\u00e9duction":[25,70],"glucon\u00e9ogen\u00e8se":[28,90],"h\u00e9patique":[29,36,53,91],"entra\u00eenant":[30],"une":[31,69,110],"baisse":[32],"production":[35,52],"glucose,":[38],"anormalement":[39],"\u00e9lev\u00e9e":[40],"au":[41],"cours":[42],"du":[43,78],"diab\u00e8te":[44],"type":[46],"2":[47],"l'inhibition":[49,62,87],"glucose":[55],"par":[56,61,92,113],"provoqu\u00e9e":[60],"cha\u00eene":[65],"respiratoire":[66],"mitochondriale":[67],"causant":[68],"balance":[73],"\u00e9nerg\u00e9tique":[74,80],"cellulaire":[75],"l'activation":[77],"senseur":[79],"AMPK":[81],"n'est":[82],"pas":[83],"n\u00e9cessaire":[84],"pour":[85],"expliquer":[86],"ind\u00e9pendamment":[96],"son":[98],"action":[99],"hypoglyc\u00e9miante,":[100],"retarde":[103],"l'apparition":[104],"complications":[106],"macrovasculaires":[107],"en":[108],"induisant":[109],"protection":[111],"cardiovasculaire":[112],"activation":[114],"l'AMPK":[116]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}