{"id":"https://openalex.org/W755563399","doi":null,"title":"Somatic-Vegetative Symptoms of Depression Predict 6-Year Increases in Insulin Resistance: Data from the Pittsburgh Healthy Heart Project","display_name":"Somatic-Vegetative Symptoms of Depression Predict 6-Year Increases in Insulin Resistance: Data from the Pittsburgh Healthy Heart Project","publication_year":2013,"publication_date":"2013-04-05","ids":{"openalex":"https://openalex.org/W755563399","mag":"755563399"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/5481","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/5481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Other"},"volume":null,"type":"other","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011438778","display_name":"Tasneem Khambaty","orcid":"https://orcid.org/0000-0003-0504-0805","observed_orcids":["https://orcid.org/0000-0003-0504-0805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tasneem Khambaty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0504-0805","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087835694","display_name":"Jesse C. Stewart","orcid":"https://orcid.org/0000-0001-7377-8823","observed_orcids":["https://orcid.org/0000-0001-7377-8823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jesse C. Stewart","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7377-8823","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039585998","display_name":"Matthew F. Muldoon","orcid":"https://orcid.org/0000-0002-2111-6331","observed_orcids":["https://orcid.org/0000-0002-2111-6331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew F. Muldoon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2111-6331","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032214993","display_name":"Thomas W. Kamarck","orcid":"https://orcid.org/0000-0002-6141-726X","observed_orcids":["https://orcid.org/0000-0002-6141-726X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas W. Kamarck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9459999799728394},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/bidirectional-association","display_name":"bidirectional relationship","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cognitive-affective-symptoms","display_name":"cognitive-affective symptoms","score":0.7749999761581421},{"id":"https://openalex.org/keywords/homa","display_name":"HOMA","score":0.7229999899864197},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8270000219345093},{"id":"https://openalex.org/keywords/beck-depression-inventory-ii","display_name":"Beck Depression Inventory-II","score":0.7820000052452087},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6953285336494446},{"id":"https://openalex.org/C2779631380","wikidata":"https://www.wikidata.org/wiki/Q813655","display_name":"Beck Depression Inventory","level":3,"score":0.6663570404052734},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6238930821418762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5756052732467651},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.545921266078949},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5282988548278809},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5134145021438599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5033654570579529},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4659035801887512},{"id":"https://openalex.org/C2778535154","wikidata":"https://www.wikidata.org/wiki/Q5889863","display_name":"Homeostatic model assessment","level":4,"score":0.43136757612228394},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4282439053058624},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.35162845253944397},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27856218814849854},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19025227427482605},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.13542917370796204},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/5481","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/5481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Other"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/5481","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/5481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Other"},{"id":"mag:755563399","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/bitstream/1805/5481/1/Khambaty-somatic.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2316436555","https://openalex.org/W2323552276","https://openalex.org/W826033726","https://openalex.org/W1988003817","https://openalex.org/W4407450517","https://openalex.org/W1946994518","https://openalex.org/W3196419638","https://openalex.org/W4294992977","https://openalex.org/W2062265189","https://openalex.org/W2043835939"],"abstract_inverted_index":{"Although":[0],"prospective":[1,83],"studies":[2,14],"suggest":[3],"a":[4,82,105,153,207,236],"bidirectional":[5,36],"association":[6],"between":[7,38],"depression":[8,274],"and":[9,41,47,88,103,113,120,144,161,165,183,279,291],"type":[10,57,293],"2":[11,58,294],"diabetes,":[12],"few":[13],"have":[15],"examined":[16,116,148],"depressive":[17,45,101],"symptom":[18],"clusters":[19,43],"or":[20,201,258],"concurrently":[21],"evaluated":[22],"both":[23],"directions":[24],"of":[25,44,56,125,137,155,209,218,238,273,288],"this":[26],"relationship.":[27],"Consequently,":[28],"our":[29],"objective":[30],"was":[31,206,220],"to":[32,99,108],"examine":[33],"the":[34,39,54,77,89,94,129,188,197,213,231,245,270],"longitudinal,":[35],"associations":[37],"somatic-vegetative":[40,191,271],"cognitive-affective":[42,202,259],"symptoms":[46,102,272],"insulin":[48,112,138,143,289],"resistance,":[49],"which":[50],"is":[51],"implicated":[52],"in":[53,76,128,158,212,254],"pathophysiology":[55],"diabetes.":[59,295],"Participants":[60],"were":[61,168],"269":[62],"adults":[63,268],"(baseline":[64],"age":[65],"range:":[66],"50-70":[67],"years,":[68],"55%":[69],"female,":[70],"14%":[71],"non-white)":[72],"without":[73],"diabetes":[74],"enrolled":[75],"Pittsburgh":[78],"Healthy":[79],"Heart":[80],"Project,":[81],"cohort":[84],"study.":[85],"At":[86],"baseline":[87,117,149,174,180,189,246],"6-year":[90,126,156,210,252],"visits,":[91],"participants":[92],"completed":[93],"Beck":[95],"Depression":[96],"Inventory-II":[97],"(BDI-II)":[98],"assess":[100],"underwent":[104],"blood":[106],"draw":[107],"quantify":[109],"fasting":[110,142],"serum":[111],"glucose.":[114,145],"We":[115,146],"BDI-II":[118,159,166,190,232,255],"total":[119,160,198,233],"subscale":[121,162],"scores":[122,260],"as":[123,152,170],"predictors":[124],"change":[127,157,167,240,253],"homeostatic":[130],"model":[131],"assessment":[132],"(HOMA)":[133],"score,":[134],"an":[135,285],"index":[136],"resistance":[139,290],"computed":[140,169],"from":[141],"also":[147],"HOMA":[150,164,181,214,239,247],"score":[151,172,182,192,234,248],"predictor":[154,208,237],"scores.":[163],"follow-up":[171],"minus":[173],"score.":[175,215],"Regression":[176],"analyses,":[177],"adjusted":[178],"for":[179,225],"demographic":[184],"factors,":[185],"revealed":[186],"that":[187,230,266],"(beta=.14,":[193],"p=.03),":[194],"but":[195],"not":[196,250],"(beta=.10,":[199],"p=.11)":[200],"(beta=.004,":[203],"p=.95)":[204],"scores,":[205],"increases":[211],"The":[216],"pattern":[217],"results":[219],"similar":[221],"after":[222],"further":[223],"adjustment":[224],"body":[226],"mass":[227],"index,":[228],"except":[229],"became":[235],"(beta=.13,":[241],"p=.03).":[242],"In":[243],"contrast,":[244],"did":[249],"predict":[251],"total,":[256],"somatic-vegetative,":[257],"(all":[261],"p\u2019s>.48).":[262],"Our":[263],"findings":[264],"indicate":[265],"older":[267],"experiencing":[269],"(e.g.,":[275],"fatigue,":[276],"sleep":[277],"disturbance,":[278],"appetite":[280],"changes)":[281],"may":[282],"be":[283],"at":[284],"increased":[286],"risk":[287],"subsequent":[292]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}