{"id":"https://openalex.org/W75528669","doi":null,"title":"Regulation of hematopoiesis in rats exposed to antiorthostatic, hypokinetic/hypodynamia: I. Model description.","display_name":"Regulation of hematopoiesis in rats exposed to antiorthostatic, hypokinetic/hypodynamia: I. Model description.","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W75528669","mag":"75528669","pmid":"https://pubmed.ncbi.nlm.nih.gov/4004676"},"language":"en","primary_location":{"id":"pmid:4004676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4004676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020218444","display_name":"C. D. R. Dunn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C D Dunn","raw_affiliation_strings":["Northrop Services, Inc. Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northrop Services, Inc. Houston, TX, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103518559","display_name":"Philip C. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P C Johnson","raw_affiliation_strings":["Northrop Services Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northrop Services Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103226189","display_name":"R. D. Lange","orcid":"https://orcid.org/0000-0001-5328-2791","observed_orcids":["https://orcid.org/0000-0001-5328-2791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Lange","raw_affiliation_strings":["Northrop Services Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northrop Services Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Perez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Perez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034866131","display_name":"R. Nessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Nessel","raw_affiliation_strings":["Northrop Services, Inc., Life Sciences Laboratory; Baylor College of Medicine; NASA, Johnson Space Center Houston, TX; Tennessee, University, Knoxville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northrop Services, Inc., Life Sciences Laboratory; Baylor College of Medicine; NASA, Johnson Space Center Houston, TX; Tennessee, University, Knoxville, United States","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7444,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.67618229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"56","issue":"5","first_page":"419","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.7089999914169312},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/red-blood-cell-mass","display_name":"red cell mass","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.9629999995231628},{"id":"https://openalex.org/keywords/plasma-volume","display_name":"plasma volume","score":0.9480000138282776},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7120000123977661},{"id":"https://openalex.org/keywords/food-and-water-intake","display_name":"food and water intake","score":0.6850000023841858},{"id":"https://openalex.org/keywords/oxyhemoglobin-dissociation-curve","display_name":"oxygen dissociation curve","score":0.9359999895095825},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9169999957084656},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.8498811721801758},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6206595301628113},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.5815646648406982},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5187492370605469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5159178972244263},{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.495279461145401},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.4304622709751129},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.42104750871658325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40958699584007263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31364452838897705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25409412384033203},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.21953746676445007},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14262709021568298},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.14017489552497864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11436545848846436},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004911","descriptor_name":"Erythrocyte Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010953","descriptor_name":"Plasma Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4004676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4004676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},{"id":"mag:75528669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4004676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1009679433","https://openalex.org/W161249652","https://openalex.org/W117709648","https://openalex.org/W286069936","https://openalex.org/W270512894","https://openalex.org/W2431282317","https://openalex.org/W2081601601","https://openalex.org/W2177083770","https://openalex.org/W806923664","https://openalex.org/W2401343635"],"abstract_inverted_index":{"This":[0],"paper":[1],"provides":[2],"baseline":[3],"information":[4],"regarding":[5],"the":[6,19,24,48,95,101,182,191,199],"regulation":[7],"of":[8,18,27,120,126,198,203],"hematopoiesis":[9,121],"in":[10,35,40,47,63,69,86,94,100,140,145,152,163,170,173,181,187,223],"antiorthostatic,":[11],"hypokinetic/hypodynamic":[12],"(\"suspended\")":[13],"laboratory":[14],"rats.":[15,38,184],"The":[16],"object":[17],"study":[20],"was":[21,51],"to":[22,44,66,81,107,156,168,195,220],"compare":[23],"hematological":[25,201],"effects":[26,202,218],"suspension":[28,143],"with":[29],"those":[30,221],"seen":[31],"following":[32],"space":[33,111,130,148,153,157,204,224],"flight":[34,112,131,205],"man":[36,41,146,151],"and/or":[37],"Observed":[39],"after":[42,142],"exposure":[43],"microgravity":[45],"and":[46,83,88,132,206],"suspended":[49,183],"rats":[50,127,141],"a":[52,60,67,72,76,84,123,188,210],"reduced":[53],"red":[54,174],"blood":[55,175],"cell":[56,176],"mass,":[57],"suppressed":[58],"erythropoiesis,":[59],"transient":[61],"increase":[62],"hematocrit":[64,74],"due":[65],"reduction":[68,85],"plasma":[70],"volume,":[71],"post-exposure":[73],"decrease,":[75],"weight":[77],"loss":[78],"(or":[79],"failure":[80],"thrive)":[82],"food":[87],"water":[89],"consumption.":[90],"A":[91],"rightward":[92],"shift":[93],"oxyhemoglobin":[96],"dissociation":[97],"curve,":[98],"observed":[99,180],"rat":[102,192],"\"model\",":[103],"has":[104,114],"been":[105,117],"predicted":[106],"occur":[108],"during":[109,128,147],"manned":[110],"but":[113,154],"not":[115],"yet":[116],"measured.":[118],"Suppression":[119],"is":[122],"common":[124],"feature":[125],"both":[129],"suspension.":[133],"Platelet":[134],"counts":[135],"showed":[136],"no":[137,160],"significant":[138,161],"change":[139,162],"or":[144,166,172],"flight.":[149,225],"Unlike":[150],"similar":[155,219],"flight-exposed":[158],"rats,":[159],"leukocyte":[164],"number":[165],"reactivity":[167],"PHA":[169],"vitro,":[171],"shape":[177],"distribution":[178],"were":[179],"At":[185],"least":[186],"gross":[189],"sense,":[190],"\"model\"":[193],"seems":[194],"reproduce":[196],"many":[197],"known":[200],"offers":[207],"promise":[208],"as":[209],"1":[211],"X":[212],"g":[213],"analog":[214],"for":[215],"understanding":[216],"hematopoietic":[217],"found":[222]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}