{"id":"https://openalex.org/W75516595","doi":"https://doi.org/10.1007/978-3-642-85036-3_39","title":"From Localized Angioedema to Generalized Capillary Leak Syndrome: Evidence for a Pivotal Role of C1-Inhibitor in Septic Shock-like Syndromes","display_name":"From Localized Angioedema to Generalized Capillary Leak Syndrome: Evidence for a Pivotal Role of C1-Inhibitor in Septic Shock-like Syndromes","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W75516595","doi":"https://doi.org/10.1007/978-3-642-85036-3_39","mag":"75516595"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-85036-3_39","doi":"https://doi.org/10.1007/978-3-642-85036-3_39","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-85036-3_39","pdf_url":null,"source":{"id":"https://openalex.org/S4210188610","display_name":"Update in intensive care and emergency medicine","issn_l":"0933-6788","issn":["0933-6788"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Update in Intensive Care and Emergency Medicine","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4243818344","display_name":"Sepsis"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087957042","display_name":"Bernd Eisele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Eisele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111479528","display_name":"U. Delvos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Delvos","raw_affiliation_strings":["Klinik f\u00fcr An\u00e4sthesiologie und operative Intensivmedizin, Universit\u00e4tsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr An\u00e4sthesiologie und operative Intensivmedizin, Universit\u00e4tsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.576,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.95860927,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"501","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":0.9589999914169312},{"id":"https://openalex.org/keywords/capillary-leak","display_name":"capillary leak syndrome","score":0.875},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8669999837875366},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.7080000042915344},{"id":"https://openalex.org/keywords/laryngeal-edema","display_name":"laryngeal edema","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acute-edema","display_name":"acute edema","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.905657172203064},{"id":"https://openalex.org/C2779931649","wikidata":"https://www.wikidata.org/wiki/Q416510","display_name":"C1-inhibitor","level":3,"score":0.8975750803947449},{"id":"https://openalex.org/C2910317908","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Laryngeal Edema","level":3,"score":0.7604599595069885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7391509413719177},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.6110105514526367},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.6019402742385864},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5506342649459839},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.49198290705680847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4322066307067871},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4282737970352173},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3412705063819885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22179055213928223},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.14084947109222412},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0879141092300415}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-85036-3_39","doi":"https://doi.org/10.1007/978-3-642-85036-3_39","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-85036-3_39","pdf_url":null,"source":{"id":"https://openalex.org/S4210188610","display_name":"Update in intensive care and emergency medicine","issn_l":"0933-6788","issn":["0933-6788"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Update in Intensive Care and Emergency Medicine","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":154,"referenced_works":["https://openalex.org/W136462","https://openalex.org/W1570583","https://openalex.org/W2509486","https://openalex.org/W29729594","https://openalex.org/W75077106","https://openalex.org/W88778322","https://openalex.org/W125060595","https://openalex.org/W156655195","https://openalex.org/W186535071","https://openalex.org/W207881829","https://openalex.org/W1015794409","https://openalex.org/W1458582449","https://openalex.org/W1482527259","https://openalex.org/W1517745405","https://openalex.org/W1518078761","https://openalex.org/W1522956225","https://openalex.org/W1525695022","https://openalex.org/W1541257540","https://openalex.org/W1549537825","https://openalex.org/W1565281311","https://openalex.org/W1567817045","https://openalex.org/W1583938359","https://openalex.org/W1586693932","https://openalex.org/W1586883593","https://openalex.org/W1586938382","https://openalex.org/W1595215626","https://openalex.org/W1658552097","https://openalex.org/W1828515792","https://openalex.org/W1864963307","https://openalex.org/W1927246203","https://openalex.org/W1938898757","https://openalex.org/W1962157066","https://openalex.org/W1968713831","https://openalex.org/W1968726446","https://openalex.org/W1973086032","https://openalex.org/W1973628811","https://openalex.org/W1975045605","https://openalex.org/W1976772170","https://openalex.org/W1977749835","https://openalex.org/W1977835480","https://openalex.org/W1978596032","https://openalex.org/W1980895202","https://openalex.org/W1989289423","https://openalex.org/W1991071152","https://openalex.org/W1991352557","https://openalex.org/W1992644897","https://openalex.org/W1997451389","https://openalex.org/W1997943569","https://openalex.org/W1999246265","https://openalex.org/W1999607221","https://openalex.org/W2002121879","https://openalex.org/W2002380239","https://openalex.org/W2003126735","https://openalex.org/W2003422570","https://openalex.org/W2003646304","https://openalex.org/W2006887827","https://openalex.org/W2007064544","https://openalex.org/W2008557677","https://openalex.org/W2009449692","https://openalex.org/W2011291552","https://openalex.org/W2013537752","https://openalex.org/W2016092001","https://openalex.org/W2018030670","https://openalex.org/W2022522156","https://openalex.org/W2024608428","https://openalex.org/W2025948881","https://openalex.org/W2026891308","https://openalex.org/W2027616724","https://openalex.org/W2031123437","https://openalex.org/W2032954616","https://openalex.org/W2038961233","https://openalex.org/W2043330027","https://openalex.org/W2045010042","https://openalex.org/W2048395992","https://openalex.org/W2048540725","https://openalex.org/W2053297958","https://openalex.org/W2055474534","https://openalex.org/W2056951481","https://openalex.org/W2060364582","https://openalex.org/W2060625943","https://openalex.org/W2060724258","https://openalex.org/W2061235805","https://openalex.org/W2063182519","https://openalex.org/W2065699321","https://openalex.org/W2072344266","https://openalex.org/W2076032926","https://openalex.org/W2076999585","https://openalex.org/W2078186418","https://openalex.org/W2078264642","https://openalex.org/W2079008038","https://openalex.org/W2079319233","https://openalex.org/W2082388138","https://openalex.org/W2085277293","https://openalex.org/W2085406326","https://openalex.org/W2085570435","https://openalex.org/W2085886360","https://openalex.org/W2087926948","https://openalex.org/W2091849415","https://openalex.org/W2092722790","https://openalex.org/W2092750860","https://openalex.org/W2093523386","https://openalex.org/W2094619261","https://openalex.org/W2094746058","https://openalex.org/W2102613564","https://openalex.org/W2108117103","https://openalex.org/W2109277456","https://openalex.org/W2118100309","https://openalex.org/W2134543109","https://openalex.org/W2139352405","https://openalex.org/W2140422547","https://openalex.org/W2142585662","https://openalex.org/W2143732220","https://openalex.org/W2149349927","https://openalex.org/W2149470050","https://openalex.org/W2158623312","https://openalex.org/W2159750628","https://openalex.org/W2160313605","https://openalex.org/W2160388336","https://openalex.org/W2162428378","https://openalex.org/W2165314511","https://openalex.org/W2166542918","https://openalex.org/W2167447755","https://openalex.org/W2170015070","https://openalex.org/W2170500808","https://openalex.org/W2170921103","https://openalex.org/W2189510393","https://openalex.org/W2213519365","https://openalex.org/W2239006518","https://openalex.org/W2252063895","https://openalex.org/W2255626584","https://openalex.org/W2313823760","https://openalex.org/W2322553446","https://openalex.org/W2325282812","https://openalex.org/W2327269495","https://openalex.org/W2331513080","https://openalex.org/W2340244022","https://openalex.org/W2397523915","https://openalex.org/W2399815633","https://openalex.org/W2400426556","https://openalex.org/W2403506032","https://openalex.org/W2409206174","https://openalex.org/W2409775377","https://openalex.org/W2411486612","https://openalex.org/W2414383967","https://openalex.org/W2416057379","https://openalex.org/W2416280647","https://openalex.org/W2418890709","https://openalex.org/W2419672113","https://openalex.org/W2434484727","https://openalex.org/W2437841302","https://openalex.org/W2466800036","https://openalex.org/W3021972260","https://openalex.org/W4237458923","https://openalex.org/W4299963704"],"related_works":["https://openalex.org/W2903933221","https://openalex.org/W2027981062","https://openalex.org/W2068551635","https://openalex.org/W1984852174","https://openalex.org/W2419672113","https://openalex.org/W2970392282","https://openalex.org/W4233960075","https://openalex.org/W4413972707","https://openalex.org/W2943022942","https://openalex.org/W2105280280"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}