{"id":"https://openalex.org/W75500200","doi":null,"title":"Cultures perfus\u00e9es d'hybridomes dans un r\u00e9acteur agit\u00e9 avec recyclage externe des cellules : mise au point, cin\u00e9tiques et performances","display_name":"Cultures perfus\u00e9es d'hybridomes dans un r\u00e9acteur agit\u00e9 avec recyclage externe des cellules : mise au point, cin\u00e9tiques et performances","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W75500200","mag":"75500200"},"language":"fr","primary_location":{"id":"pmh:oai:univ-lorraine.fr:univ-lorraine-ori-31825","doi":null,"is_oa":false,"landing_page_url":"http://docnum.univ-lorraine.fr/prive/INPL_T_1991_PINTON_H.pdf","pdf_url":"http://docnum.univ-lorraine.fr/prive/INPL_T_1991_PINTON_H.pdf","source":{"id":"https://openalex.org/S4306400741","display_name":"Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102194","host_organization_name":"Laboratoire de Cristallographie, R\u00e9sonance Magn\u00e9tique et Mod\u00e9lisations","host_organization_lineage":["https://openalex.org/I4210102194"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064111144","display_name":"Herv\u00e9 Pinton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Herv\u00e9 Pinton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064111144"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hybridoma-culture","display_name":"hybridoma cell culture","score":0.8830000162124634},{"id":"https://openalex.org/keywords/perfusion-culture","display_name":"perfusion culture","score":0.6299999952316284},{"id":"https://openalex.org/keywords/stirred-tank-reactor","display_name":"stirred tank reactor","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tangential-microfiltration","display_name":"tangential microfiltration","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hollow-fiber-membrane-module","display_name":"hollow fiber membrane module","score":0.8960000276565552},{"id":"https://openalex.org/keywords/continuous-culture","display_name":"continuous culture","score":0.503000020980835},{"id":"https://openalex.org/keywords/cell-kinetics","display_name":"cell kinetics","score":0.46700000762939453},{"id":"https://openalex.org/keywords/cell-lysis","display_name":"cell lysis","score":0.5149999856948853},{"id":"https://openalex.org/keywords/cell-cycle-analysis","display_name":"cell cycle analysis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-release","display_name":"lactate dehydrogenase release","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.38600000739097595},{"id":"https://openalex.org/keywords/high-cell-density","display_name":"high cell density","score":0.5879999995231628},{"id":"https://openalex.org/keywords/culture-medium-composition","display_name":"culture medium composition","score":0.40299999713897705},{"id":"https://openalex.org/keywords/residence-time","display_name":"residence time","score":0.5619999766349792},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.5}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5773545503616333},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.517917811870575},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4283060133457184},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.377913236618042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3256256580352783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08541309833526611}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:univ-lorraine.fr:univ-lorraine-ori-31825","doi":null,"is_oa":false,"landing_page_url":"http://docnum.univ-lorraine.fr/prive/INPL_T_1991_PINTON_H.pdf","pdf_url":"http://docnum.univ-lorraine.fr/prive/INPL_T_1991_PINTON_H.pdf","source":{"id":"https://openalex.org/S4306400741","display_name":"Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102194","host_organization_name":"Laboratoire de Cristallographie, R\u00e9sonance Magn\u00e9tique et Mod\u00e9lisations","host_organization_lineage":["https://openalex.org/I4210102194"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:hdl:10068/16890","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/16890","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-01752167v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/tel-01752167v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autre. Institut National Polytechnique de Lorraine, 1991. Fran\u00e7ais. &#x27E8;NNT : 1991INPL085N&#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:75500200","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1991INPL085N","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392490748","https://openalex.org/W374130243","https://openalex.org/W4392490742","https://openalex.org/W122974159","https://openalex.org/W6980785794","https://openalex.org/W4400182426","https://openalex.org/W2902532679","https://openalex.org/W7000825980","https://openalex.org/W853503691","https://openalex.org/W7017883876"],"abstract_inverted_index":{"L'objectif":[0],"g\u00e9n\u00e9ral":[1],"de":[2,15,22,29,78,81,90,96,112,147,154,162,165,180,203],"cette":[3],"\u00e9tude":[4],"est":[5],"la":[6,47,51,61,119,150,204,226],"mise":[7,52],"en":[8,76,88,131,142,157,210],"\u0153uvre":[9],"optimale":[10],"d'un":[11],"nouveau":[12],"proc\u00e9d\u00e9":[13],"continu":[14],"culture":[16,113,155,211],"d'hybridomes,":[17],"bas\u00e9":[18],"sur":[19],"une":[20,63,105,123,221,232],"configuration":[21],"r\u00e9acteur":[23,89,95,132],"agit\u00e9":[24],"coupl\u00e9":[25],"\u00e0":[26,60,102,186,225,236,243],"un":[27],"module":[28],"fibres":[30],"creuses":[31],"permettant":[32],"le":[33,145,199],"recyclage":[34],"des":[35,68,85,107,129,136,171,183,208,212,215,240],"cellules":[36,172,213],"par":[37,194,207],"microfiltration":[38],"tangentielle.":[39],"Deux":[40],"grandes":[41],"parties":[42],"peuvent":[43],"\u00eatre":[44],"d\u00e9gag\u00e9es":[45],":":[46],"premi\u00e8re":[48],"partie":[49,121],"concerne":[50],"au":[53,94],"point":[54],"technologique":[55,223],"du":[56,74,127,152,196,201,238],"syst\u00e8me.":[57],"Elle":[58],"inclut":[59],"fois":[62],"approche":[64,124,222,233],"hydrodynamique":[65],"et":[66,80,104,149,156,164,175,206,228,231],"environnementale":[67],"facteurs":[69],"pouvant":[70],"influencer":[71],"les":[72,159],"performances":[73,108,230],"syst\u00e8me":[75,179],"terme":[77],"long\u00e9vit\u00e9":[79],"productivit\u00e9.":[82],"A":[83],"partir":[84],"r\u00e9sultats":[86],"obtenus":[87],"deux":[91],"litres,":[92],"l'extrapolation":[93],"vingt":[97],"litres":[98],"a":[99,114,139,189],"\u00e9t\u00e9":[100,115,140,190],"men\u00e9e":[101],"bien":[103],"comparaison":[106],"avec":[109],"d'autres":[110],"syst\u00e8mes":[111],"faite.":[116],"Par":[117],"ailleurs,":[118],"seconde":[120],"d\u00e9veloppe":[122],"plus":[125,192],"approfondie":[126],"comportement":[128,239],"hybridomes":[130,241],"perfus\u00e9":[133],"homog\u00e8ne.":[134],"L'analyse":[135],"exigences":[137],"nutritionnelles":[138],"r\u00e9alis\u00e9e,":[141],"faisant":[143],"varier":[144],"temps":[146],"s\u00e9jour":[148],"composition":[151],"milieu":[153],"quantifiant":[158],"vitesses":[160],"sp\u00e9cifiques":[161],"consommation":[163],"production.":[166],"De":[167],"plus,":[168],"l'\u00e9tat":[169],"physiologique":[170],"(prolif\u00e9ration,":[173],"d\u00e9c\u00e8s":[174],"lyse)":[176],"dans":[177],"ce":[178],"culture,":[181],"lors":[182],"\u00e9tats":[184],"stationnaires":[185],"haute":[187],"densit\u00e9,":[188],"caract\u00e9ris\u00e9":[191],"finement":[193],"l'analyse":[195],"cycle":[197],"cellulaire,":[198],"suivi":[200],"relargage":[202],"LDH":[205],"remises":[209],"provenant":[214],"r\u00e9acteurs":[216],"perfus\u00e9s.":[217],"Ces":[218],"travaux":[219],"allient":[220],"li\u00e9e":[224,235],"productivit\u00e9":[227],"aux":[229],"fondamentale":[234],"l'\u00e9tude":[237],"cultiv\u00e9s":[242],"fortes":[244],"concentrations":[245],"cellulaires":[246]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
