{"id":"https://openalex.org/W75489403","doi":null,"title":"Dopamine partial agonism in antipsychotic-induced sexual dysfunction.","display_name":"Dopamine partial agonism in antipsychotic-induced sexual dysfunction.","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W75489403","mag":"75489403","pmid":"https://pubmed.ncbi.nlm.nih.gov/23592073"},"language":"en","primary_location":{"id":"pmh:oai:actaspsiquiatria.es:article/806","doi":null,"is_oa":true,"landing_page_url":"https://actaspsiquiatria.es/index.php/actas/article/view/806","pdf_url":"https://actaspsiquiatria.es/index.php/actas/article/download/806/1268","source":{"id":"https://openalex.org/S167709542","display_name":"Actas Espa\u00f1olas de Psiquiatr\u00eda","issn_l":"1139-9287","issn":["1139-9287","1578-2735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4365328534","host_organization_name":"Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor","host_organization_lineage":["https://openalex.org/P4365328534"],"host_organization_lineage_names":["Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1139-9287","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://actaspsiquiatria.es/index.php/actas/article/download/806/1268","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072998385","display_name":"Natalia Mesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Natalia Mesa","raw_affiliation_strings":["Servicio de Psiquiatr\u00eda, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (i+12), Madrid, Espa\u00f1a. nataliamr79@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Psiquiatr\u00eda, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (i+12), Madrid, Espa\u00f1a. nataliamr79@gmail.com","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036916214","display_name":"Jose de la Oliva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose de la Oliva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091460414","display_name":"Alexandra Bagney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Bagney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109144798","display_name":"Miguel \u00c1ngel Jim\u00e9nez\u2010Arriero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel A Jimenez-Arriero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019570575","display_name":"Roberto Rodr\u00edguez\u2013Jim\u00e9nez","orcid":"https://orcid.org/0000-0003-2251-7249","observed_orcids":["https://orcid.org/0000-0003-2251-7249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Rodriguez-Jimenez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5953,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.67460749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"41","issue":"2","first_page":"130","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hyperprolactinemia","display_name":"hyperprolactinemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/amenorrhea","display_name":"amenorrhea","score":0.8349999785423279},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":1.0},{"id":"https://openalex.org/keywords/first-episode-psychosis","display_name":"first-episode psychosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5350000262260437},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.7732105255126953},{"id":"https://openalex.org/C2778093883","wikidata":"https://www.wikidata.org/wiki/Q1137463","display_name":"Sexual dysfunction","level":2,"score":0.7191685438156128},{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.7184342741966248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6008788347244263},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5816718935966492},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5384556651115417},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.47681257128715515},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.4634222090244293},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4617019295692444},{"id":"https://openalex.org/C2777393122","wikidata":"https://www.wikidata.org/wiki/Q416417","display_name":"Akathisia","level":4,"score":0.4521881639957428},{"id":"https://openalex.org/C2910202354","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic Agent","level":4,"score":0.43628519773483276},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3987550735473633},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3491024971008301},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.321155309677124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28823208808898926},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28030574321746826},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068180","descriptor_name":"Aripiprazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077582","descriptor_name":"Amisulpride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012735","descriptor_name":"Sexual Dysfunction, Physiological","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012735","descriptor_name":"Sexual Dysfunction, Physiological","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013469","descriptor_name":"Sulpiride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013469","descriptor_name":"Sulpiride","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:actaspsiquiatria.es:article/806","doi":null,"is_oa":true,"landing_page_url":"https://actaspsiquiatria.es/index.php/actas/article/view/806","pdf_url":"https://actaspsiquiatria.es/index.php/actas/article/download/806/1268","source":{"id":"https://openalex.org/S167709542","display_name":"Actas Espa\u00f1olas de Psiquiatr\u00eda","issn_l":"1139-9287","issn":["1139-9287","1578-2735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4365328534","host_organization_name":"Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor","host_organization_lineage":["https://openalex.org/P4365328534"],"host_organization_lineage_names":["Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1139-9287","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:23592073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23592073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Actas espanolas de psiquiatria","raw_type":"Case Reports"},{"id":"mag:75489403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23592073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:actaspsiquiatria.es:article/806","doi":null,"is_oa":true,"landing_page_url":"https://actaspsiquiatria.es/index.php/actas/article/view/806","pdf_url":"https://actaspsiquiatria.es/index.php/actas/article/download/806/1268","source":{"id":"https://openalex.org/S167709542","display_name":"Actas Espa\u00f1olas de Psiquiatr\u00eda","issn_l":"1139-9287","issn":["1139-9287","1578-2735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4365328534","host_organization_name":"Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor","host_organization_lineage":["https://openalex.org/P4365328534"],"host_organization_lineage_names":["Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1139-9287","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W75489403.pdf","grobid_xml":"https://content.openalex.org/works/W75489403.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W49211676","https://openalex.org/W95144243","https://openalex.org/W1558808869","https://openalex.org/W1821416578","https://openalex.org/W1964214733","https://openalex.org/W1972203123","https://openalex.org/W1978123597","https://openalex.org/W1987902149","https://openalex.org/W1995601667","https://openalex.org/W1996814532","https://openalex.org/W2009652756","https://openalex.org/W2022921024","https://openalex.org/W2027838310","https://openalex.org/W2048570687","https://openalex.org/W2054296290","https://openalex.org/W2071033221","https://openalex.org/W2076424478","https://openalex.org/W2088003466","https://openalex.org/W2141464904","https://openalex.org/W2143189599","https://openalex.org/W2172047405"],"related_works":["https://openalex.org/W7217563912","https://openalex.org/W3048081799","https://openalex.org/W4385669302","https://openalex.org/W3033464736","https://openalex.org/W1978123597","https://openalex.org/W2592300534","https://openalex.org/W2301266862","https://openalex.org/W4294189368","https://openalex.org/W2125553860","https://openalex.org/W1981330948"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Sexual":[1],"dysfunction":[2,89,125],"is":[3,13,29],"a":[4,78,107,151],"frequent":[5],"side":[6,51,103],"effect":[7],"associated":[8],"with":[9,73,119,182],"antipsychotic":[10,32,100,128,185],"treatment.":[11,186],"It":[12],"known":[14],"to":[15,60,97,127],"be":[16],"caused":[17],"by":[18],"the":[19,24,67,93,120,156,160,170,173,178,183],"hyperprolactinemia":[20],"that":[21,28],"results":[22],"from":[23],"D2":[25,35,74],"receptor":[26],"blockade":[27],"characteristic":[30],"of":[31,39,69,81,85,95,122,135,137,162,172],"drugs.":[33],"The":[34],"partial":[36],"dopaminergic":[37,75],"agonism":[38],"aripiprazole":[40,96,163],"could":[41],"explain":[42],"why":[43],"its":[44],"use":[45,161],"does":[46],"not":[47],"usually":[48],"cause":[49],"this":[50],"effect,":[52],"and":[53,87,133,146],"may":[54],"even":[55],"revert":[56],"it":[57],"when":[58],"added":[59],"another":[61],"antipsychotic.":[62],"CASE":[63],"REPORTS:":[64],"We":[65],"present":[66],"cases":[68,157],"two":[70],"patients":[71],"treated":[72,149],"antagonists":[76],"for":[77,150],"first":[79,152],"episode":[80],"psychosis,":[82],"who":[83,143],"complained":[84],"amenorrhea":[86],"erectile":[88],"during":[90],"follow-up.":[91],"After":[92],"addition":[94],"their":[98],"previous":[99,184],"treatment,":[101],"these":[102],"effects":[104,175],"reverted":[105],"without":[106,176],"negative":[108],"impact":[109],"on":[110],"treatment":[111,129,167],"adherence":[112],"or":[113],"therapeutic":[114],"efficacy.":[115],"CONCLUSIONS:":[116],"Pharmacological":[117],"treatments":[118],"potential":[121],"reverting":[123],"sexual":[124],"secondary":[126],"can":[130],"improve":[131],"compliance":[132],"quality":[134],"life":[136],"our":[138],"patients,":[139],"especially":[140],"in":[141,169],"those":[142],"are":[144,147],"younger":[145],"being":[148],"psychotic":[153],"episode.":[154],"In":[155],"reported":[158],"here,":[159],"as":[164],"an":[165],"adjunctive":[166],"resulted":[168],"disappearance":[171],"undesirable":[174],"affecting":[177],"efficacy":[179],"already":[180],"achieved":[181]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}