{"id":"https://openalex.org/W754863399","doi":null,"title":"Clinical inquiries. What does the evidence tell us about treating very-high-risk patients to an LDL <70 mg/dL?","display_name":"Clinical inquiries. What does the evidence tell us about treating very-high-risk patients to an LDL <70 mg/dL?","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W754863399","mag":"754863399","pmid":"https://pubmed.ncbi.nlm.nih.gov/19961822"},"language":"en","primary_location":{"id":"pmid:19961822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19961822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of family practice","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10355/4005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Carrie Nelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrie Nelson","raw_affiliation_strings":["Rush-Copley Family Medicine Residency Program, Rush Medical College, Aurora, IL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush-Copley Family Medicine Residency Program, Rush Medical College, Aurora, IL USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083030764","display_name":"Kristin Hitchcock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin Hitchcock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019876835","display_name":"James A Bohlen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James A Bohlen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033655144","display_name":"Wail Malaty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wail Malaty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.06190172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":"12","first_page":"665","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6460000276565552},{"id":"https://openalex.org/keywords/very-high-risk-patients","display_name":"very high-risk patients","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ldl-cholesterol-targets","display_name":"LDL cholesterol targets","score":0.5899999737739563},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.7160000205039978},{"id":"https://openalex.org/keywords/statin-dose","display_name":"statin dose","score":0.6809999942779541},{"id":"https://openalex.org/keywords/major-adverse-cardiac-events","display_name":"major adverse cardiac events","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cardiac-risk","display_name":"heart disease risk","score":0.6430000066757202},{"id":"https://openalex.org/keywords/patient-oriented-outcomes","display_name":"patient-oriented outcomes","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.947803258895874},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.7456119060516357},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.639125645160675},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5089540481567383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4857824146747589},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3739093542098999}],"mesh":[{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19961822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19961822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of family practice","raw_type":"Journal Article"},{"id":"pmh:oai:https://mospace.umsystem.edu:10355/4005","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10355/4005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400929","display_name":"MOspace Institutional Repository (University of Missouri)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76835614","host_organization_name":"University of Missouri","host_organization_lineage":["https://openalex.org/I76835614"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:754863399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19961822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:https://mospace.umsystem.edu:10355/4005","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10355/4005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400929","display_name":"MOspace Institutional Repository (University of Missouri)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76835614","host_organization_name":"University of Missouri","host_organization_lineage":["https://openalex.org/I76835614"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W752895202","https://openalex.org/W2040462758","https://openalex.org/W2106343349","https://openalex.org/W2120289695","https://openalex.org/W2128408811","https://openalex.org/W2139168645","https://openalex.org/W2139543283"],"related_works":["https://openalex.org/W7162478341","https://openalex.org/W7155137783","https://openalex.org/W2415759557","https://openalex.org/W2343722442","https://openalex.org/W2279911035","https://openalex.org/W2906110193","https://openalex.org/W2740350083","https://openalex.org/W2003905161","https://openalex.org/W2016062110","https://openalex.org/W2069359796"],"abstract_inverted_index":{"No":[0,78],"studies":[1,79],"directly":[2],"compare":[3],"low-density":[4],"lipoprotein":[5],"(LDL)":[6],"levels":[7,11,29,93],"<70":[8,46],"mg/dL":[9,16,47],"to":[10,14,89],"of":[12,34,45,62,83],"71":[13],"100":[15],"in":[17],"very-high-risk":[18],"patients.":[19],"However,":[20],"no":[21],"evidence":[22],"suggests":[23],"a":[24],"\"floor\"":[25],"for":[26,85],"LDL":[27,43,69,92],"cholesterol":[28,44],"beyond":[30],"which":[31],"further":[32],"reductions":[33],"heart":[35],"disease":[36],"risk":[37],"cannot":[38],"be":[39],"achieved.":[40],"The":[41],"target":[42,91],"is":[48],"based":[49],"on":[50],"data":[51],"extrapolated":[52],"from":[53],"RCTs.":[54],"Comparing":[55],"larger":[56,66],"(80":[57],"mg)":[58],"with":[59],"smaller":[60,76],"doses":[61,67],"atorvastatin":[63],"shows":[64],"that":[65],"reduce":[68],"and":[70],"major":[71],"cardiac":[72],"events":[73],"more":[74],"than":[75],"doses.":[77],"report":[80],"patient-oriented":[81],"outcomes":[82],"treatments":[84],"patients":[86],"who":[87],"fail":[88],"reach":[90],"<100":[94],"mg/dL.":[95]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}