{"id":"https://openalex.org/W7538965","doi":null,"title":"Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.","display_name":"Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W7538965","mag":"7538965","pmid":"https://pubmed.ncbi.nlm.nih.gov/8667617"},"language":"en","primary_location":{"id":"pmid:8667617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8667617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044494633","display_name":"Jeffrey B. Kopp","orcid":"https://orcid.org/0000-0001-9052-186X","observed_orcids":["https://orcid.org/0000-0001-9052-186X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Kopp","raw_affiliation_strings":["Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090413993","display_name":"V.M. Factor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V M Factor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111618870","display_name":"M Mozes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mozes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019070285","display_name":"P\u00e9ter Nagy","orcid":"https://orcid.org/0000-0002-1664-9221","observed_orcids":["https://orcid.org/0000-0002-1664-9221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nagy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Sanderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Sanderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071606253","display_name":"Erwin P. B\u00f6ttinger","orcid":"https://orcid.org/0000-0001-6868-6676","observed_orcids":["https://orcid.org/0000-0001-6868-6676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E P B\u00f6ttinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109007146","display_name":"P E Klotman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Klotman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087862269","display_name":"Snorri S. Thorgeirsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Thorgeirsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.0569,"has_fulltext":false,"cited_by_count":424,"citation_normalized_percentile":{"value":0.99564839,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"74","issue":"6","first_page":"991","last_page":"1003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.23240000009536743,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.07329999655485153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8299999833106995},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.6320000290870667},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/extracellular-matrix-accumulation","display_name":"extracellular matrix accumulation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/mesangial-expansion","display_name":"mesangial expansion","score":0.7889999747276306},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.640999972820282},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/glomerular-immune-deposits","display_name":"glomerular immune deposits","score":0.7559999823570251},{"id":"https://openalex.org/keywords/albumin-promoter","display_name":"albumin promoter","score":0.6019999980926514},{"id":"https://openalex.org/keywords/azotemia","display_name":"azotemia","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.5981707572937012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.590198278427124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5864351987838745},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4996492862701416},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.49264436960220337},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4616256058216095},{"id":"https://openalex.org/C3018920779","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Renal glomerulus","level":4,"score":0.4553951621055603},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.44884783029556274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44307276606559753},{"id":"https://openalex.org/C2779131090","wikidata":"https://www.wikidata.org/wiki/Q3331086","display_name":"Mesangial cell","level":3,"score":0.42947471141815186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24196290969848633},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.22159340977668762},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08810931444168091}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8667617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8667617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:7538965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8667617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W61305971","https://openalex.org/W196511189","https://openalex.org/W2398429665","https://openalex.org/W2405078885"],"related_works":["https://openalex.org/W2132631212","https://openalex.org/W3176569522","https://openalex.org/W2083646381","https://openalex.org/W1579269973","https://openalex.org/W1984828038","https://openalex.org/W2082401103","https://openalex.org/W2336109487","https://openalex.org/W2015703206","https://openalex.org/W2012008369","https://openalex.org/W7098831516"],"abstract_inverted_index":{"Several":[0],"lines":[1,95,103],"of":[2,8,21,38,56,62,84,93,96,108,137,155,163,183,189,225,240,263],"evidence":[3],"suggest":[4,257],"that":[5,26,49,233,258],"local":[6],"production":[7],"transforming":[9],"growth":[10],"factor-beta":[11],"(TGF-beta)":[12],"contributes":[13],"to":[14,18],"renal":[15,231],"disease,":[16],"particularly":[17],"the":[19,22,43,60,73,77,105,113,132,150,184],"accumulation":[20,239],"extracellular":[23,212],"matrix":[24,213,245],"protein":[25],"characterizes":[27],"glomerulosclerosis":[28],"and":[29,66,79,112,125,141,173,198,220,244,247],"interstitial":[30,248],"fibrosis.":[31],"We":[32,45],"have":[33,46,80],"examined":[34],"whether":[35],"elevated":[36,81,260],"levels":[37,107,154,224,262],"circulating":[39,226,261],"TGF-beta":[40,57,85,116,156,227,264],"adversely":[41],"affect":[42],"kidney.":[44],"studied":[47],"mice":[48,71,166,185],"are":[50],"transgenic":[51,99,252],"for":[52],"an":[53,209],"active":[54],"form":[55],"1":[58,98,117,228,265],"under":[59],"control":[61],"murine":[63],"albumin":[64],"promoter":[65],"enhancer":[67],"DNA":[68],"sequences.":[69],"These":[70,165,255],"express":[72],"transgene":[74,110],"exclusively":[75],"in":[76,91,131,179,196,211,218,250],"liver":[78],"plasma":[82,115],"concentrations":[83],"1.":[86],"Renal":[87],"disease":[88,232],"was":[89,204,234],"seen":[90],"two":[92,102],"three":[94],"Alb/TGF-beta":[97],"mice;":[100],"these":[101],"had":[104],"highest":[106,114,153],"hepatic":[109],"expression":[111],"levels.":[118],"Histologic":[119],"abnormalities,":[120],"which":[121],"included":[122],"mesangial":[123,199,221,237],"expansion":[124],"thickened":[126],"capillary":[127],"loops,":[128],"were":[129],"noted":[130],"glomeruli":[133,192],"by":[134,160,186,236],"3":[135],"weeks":[136,162,188],"age.":[138,164,190],"Interstitial":[139],"fibrosis":[140,249],"tubular":[142],"atrophy":[143],"appeared":[144],"subsequently.":[145],"Mice":[146],"from":[147],"Line":[148],"25,":[149],"line":[151],"with":[152,171],"1,":[157],"developed":[158],"proteinuria":[159],"5":[161],"subsequently":[167],"manifested":[168],"nephrotic":[169],"syndrome":[170],"ascites":[172],"progressive":[174,230,267],"azotemia;":[175],"uremic":[176],"death":[177],"occurred":[178],"more":[180],"than":[181],"25%":[182],"15":[187],"The":[191],"contained":[193],"immune":[194,242],"deposits":[195,243],"subendothelial":[197,219],"locations,":[200],"but":[201],"complement":[202],"deposition":[203],"infrequent.":[205],"Ultrastructural":[206],"examination":[207],"revealed":[208],"increase":[210],"material,":[214],"including":[215],"collagen":[216],"fibrils,":[217],"locations.":[222],"Increased":[223],"induced":[229],"characterized":[235],"expansion,":[238],"glomerular":[241],"proteins,":[246],"this":[251],"mouse":[253],"model.":[254],"data":[256],"chronically":[259],"induce":[266],"glomerulosclerosis.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}