{"id":"https://openalex.org/W75323176","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.247.6","title":"Ellagic acid inhibits hyperplastic conversion of human adiposederived stem cells through histone deacetylase\u2010dependent mechanisms","display_name":"Ellagic acid inhibits hyperplastic conversion of human adiposederived stem cells through histone deacetylase\u2010dependent mechanisms","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W75323176","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.247.6","mag":"75323176"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.247.6","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.247.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.247.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114734510","display_name":"Inhae Kang","orcid":"https://orcid.org/0000-0002-1734-3670","observed_orcids":["https://orcid.org/0000-0002-1734-3670"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inhae Kang","raw_affiliation_strings":["Food Science and Human Nutrition University of Florida Gainesville FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition University of Florida Gainesville FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091592976","display_name":"Da Mi Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Da Mi Kim","raw_affiliation_strings":["Food Science and Human Nutrition University of Florida Gainesville FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition University of Florida Gainesville FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031073601","display_name":"Vishinu Gourninei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishinu Gourninei","raw_affiliation_strings":["Food Science and Human Nutrition University of Florida Gainesville FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition University of Florida Gainesville FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061962128","display_name":"Bo Zhao","orcid":"https://orcid.org/0000-0003-4458-2703","observed_orcids":["https://orcid.org/0000-0003-4458-2703"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Zhao","raw_affiliation_strings":["Food Science and Human Nutrition University of Florida Gainesville FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition University of Florida Gainesville FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034551982","display_name":"Neil F. Shay","orcid":"https://orcid.org/0000-0002-3021-1170","observed_orcids":["https://orcid.org/0000-0002-3021-1170"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Shay","raw_affiliation_strings":["Food Science and Technology Oregon State University Corvallis OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Technology Oregon State University Corvallis OR","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liwei Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liwei Gu","raw_affiliation_strings":["Food Science and Human Nutrition University of Florida Gainesville FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition University of Florida Gainesville FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008671228","display_name":"Soonkyu Chung","orcid":"https://orcid.org/0000-0001-6279-7017","observed_orcids":["https://orcid.org/0000-0001-6279-7017"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soonkyu Chung*","raw_affiliation_strings":["Food Science and Human Nutrition University of Florida Gainesville FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition University of Florida Gainesville FL","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00993544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0851999968290329,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ellagic-acid","display_name":"ellagic acid","score":1.0},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.652999997138977},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hdac3","display_name":"HDAC3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/visceral-obesity","display_name":"visceral obesity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6890000104904175},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.8130000233650208},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.906000018119812},{"id":"https://openalex.org/keywords/adipocyte-size","display_name":"adipocyte size","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2781464872","wikidata":"https://www.wikidata.org/wiki/Q422044","display_name":"Ellagic acid","level":4,"score":0.9465868473052979},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.8489863872528076},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6827960014343262},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6223425269126892},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.45086416602134705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4370429515838623},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3522137701511383},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2797577977180481},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.2771488428115845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26751598715782166},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.18819981813430786},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06236124038696289}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.247.6","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.247.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.247.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312834","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994192313","https://openalex.org/W2200083145","https://openalex.org/W1604597018","https://openalex.org/W2168494777","https://openalex.org/W2528448957","https://openalex.org/W4406143907","https://openalex.org/W2544147622","https://openalex.org/W3151976741","https://openalex.org/W7125505394","https://openalex.org/W1998365263"],"abstract_inverted_index":{"We":[0,78],"have":[1],"previously":[2],"reported":[3],"that":[4,73,127,178],"Muscadine":[5],"grape":[6],"polyphenols":[7],"(MGP)":[8],"reduced":[9,56],"high":[10],"fat":[11,50,57],"diet\u2010mediated":[12],"visceral":[13,24],"obesity":[14,25],"in":[15,45,65,110],"vivo.":[16],"However,":[17],"underlying":[18],"mechanisms":[19],"by":[20,136,159],"which":[21],"MGP":[22,41,66,74,84,95],"reverses":[23],"is":[26],"unknown.":[27],"The":[28],"aim":[29],"of":[30,40,83,108,141,165,184,197],"this":[31],"study":[32],"was":[33,62],"to":[34,69],"determine":[35],"the":[36,70,81,102,115,124,130,138],"novel":[37],"inhibitory":[38],"roles":[39],"on":[42,85],"hypertrophic":[43,76],"(increase":[44],"size)":[46],"or":[47],"hyperplastic":[48,182],"(new":[49],"cell":[51],"formation)":[52],"obesity.":[53,77],"Consistent":[54],"with":[55,162],"mass,":[58],"epididymal":[59],"adipocyte":[60],"size":[61],"significantly":[63],"smaller":[64],"group":[67],"compared":[68],"HF\u2010control,":[71],"suggesting":[72],"reduces":[75],"also":[79],"investigated":[80],"effects":[82],"adipogenesis":[86,135],"using":[87],"human":[88],"adipose\u2010derived":[89],"stem":[90],"cells":[91],"(hASCs).":[92],"After":[93],"fractionating":[94],"into":[96],"anthocyanin":[97],"and":[98,152,169,199],"non\u2010anthocyanin":[99,103],"fractions,":[100],"only":[101],"fraction":[104],"inhibited":[105],"adipogenic":[106,147],"conversion":[107,183],"hASCs":[109,185],"a":[111],"dose\u2010dependent":[112],"manner.":[113],"Among":[114],"non\u2010anthocyanidin":[116],"polyphenols,":[117],"ellagic":[118,160,179],"acid":[119,133,161,180],"has":[120],"been":[121],"identified":[122],"as":[123],"responsible":[125],"polyphenol":[126],"exclusively":[128],"represses":[129],"adipogenesis.":[131],"Ellagic":[132],"repressed":[134],"blocking":[137],"obligatory":[139],"reduction":[140],"histone":[142],"deacetylase":[143],"(HDAC)":[144],"activity":[145,188],"for":[146],"gene":[148],"transcription.":[149],"Both":[150],"TSA\u2010sensitive":[151],"\u2010":[153],"insensitive":[154],"HDAC":[155,187],"activities":[156],"were":[157],"modified":[158],"selective":[163],"increases":[164],"HADAC":[166],"1,":[167],"2":[168],"4,":[170],"but":[171],"not":[172],"HADC3.":[173],"Collectively,":[174],"these":[175],"data":[176],"suggest":[177],"attenuates":[181],"via":[186],"mediated\u2010epigenetic":[189],"modification.":[190],"Grant":[191],"Funding":[192],"Source":[193],":":[194],"Florida":[195],"Department":[196],"Agriculture":[198],"Consumer":[200],"Service,":[201],"Viticulture":[202],"Research":[203],"Program":[204]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
