{"id":"https://openalex.org/W75201038","doi":null,"title":"Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies.","display_name":"Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies.","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W75201038","mag":"75201038","pmid":"https://pubmed.ncbi.nlm.nih.gov/1962062"},"language":"en","primary_location":{"id":"pmid:1962062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1962062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue neurologique","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088239162","display_name":"Guglielmo Scarlato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Scarlato","raw_affiliation_strings":["Institute of Clinical Neurology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Neurology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076321492","display_name":"Nereo Bresolin","orcid":"https://orcid.org/0000-0001-6694-3595","observed_orcids":["https://orcid.org/0000-0001-6694-3595"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N Bresolin","raw_affiliation_strings":["Fondazione IRCCS C\u00e1 Granda-Ospedale Maggiore Policlinico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione IRCCS C\u00e1 Granda-Ospedale Maggiore Policlinico","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075045812","display_name":"Isabella Moroni","orcid":"https://orcid.org/0000-0002-3322-1681","observed_orcids":["https://orcid.org/0000-0002-3322-1681"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I Moroni","raw_affiliation_strings":["Fondazione IRCCS Istituto Neurologico C. Besta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione IRCCS Istituto Neurologico C. Besta","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014274199","display_name":"Carlo Doriguzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Doriguzzi","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102929750","display_name":"Enrico Castelli","orcid":"https://orcid.org/0000-0003-1685-8936","observed_orcids":["https://orcid.org/0000-0003-1685-8936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Castelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031953083","display_name":"Giacomo P. Comi","orcid":"https://orcid.org/0000-0002-1383-5248","observed_orcids":["https://orcid.org/0000-0002-1383-5248"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Comi","raw_affiliation_strings":["Fondazione IRCCS C\u00e1 Granda-Ospedale Maggiore Policlinico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione IRCCS C\u00e1 Granda-Ospedale Maggiore Policlinico","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034751093","display_name":"Corrado Italo Angelini","orcid":"https://orcid.org/0000-0002-9554-8794","observed_orcids":["https://orcid.org/0000-0002-9554-8794"]},"institutions":[{"id":"https://openalex.org/I4210130664","display_name":"IRCCS San Camillo Hospital","ror":"https://ror.org/03njebb69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210130664","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Angelini","raw_affiliation_strings":["Istituto di Neuroriabilitazione Motoria San Camillo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Neuroriabilitazione Motoria San Camillo","institution_ids":["https://openalex.org/I4210130664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012546573","display_name":"Angelo Carenzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Carenzi","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3964,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.53324636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"147","issue":"6-7","first_page":"542","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-myopathy","display_name":"mitochondrial myopathy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.8550000190734863},{"id":"https://openalex.org/keywords/exercise-induced-lactate","display_name":"exercise-induced lactate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mitochondrial-dna-deletions","display_name":"mitochondrial DNA deletions","score":0.8949999809265137},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.625},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7293671369552612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7111722230911255},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6093103289604187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5726263523101807},{"id":"https://openalex.org/C2775833069","wikidata":"https://www.wikidata.org/wiki/Q6881881","display_name":"Mitochondrial myopathy","level":4,"score":0.5725675821304321},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37246865034103394},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.30710408091545105},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23193806409835815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09677207469940186},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07242476940155029},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:1962062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1962062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue neurologique","raw_type":"Clinical Trial"},{"id":"pmh:oai:www.research.unipd.it:11577/3353767","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3353767","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research.unipd.it:11577/3450351","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3450351","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:75201038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1962062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2078343464","https://openalex.org/W1487623199","https://openalex.org/W2076171440","https://openalex.org/W1603646385","https://openalex.org/W2043823315","https://openalex.org/W7163683903","https://openalex.org/W2049986040","https://openalex.org/W2092352962","https://openalex.org/W112837459","https://openalex.org/W2021047761"],"abstract_inverted_index":{"Fourty":[0],"four":[1],"patients":[2,30,106],"with":[3,8,74,111],"mitochondrial":[4],"myopathies":[5],"were":[6,27,41,68,93],"treated":[7,70],"Ubidecarenone":[9],"(CoQ10)":[10],"for":[11,71],"six":[12],"months":[13,73],"in":[14,53,78,104,109,134],"an":[15],"open":[16],"multicentric":[17],"trial.":[18],"No":[19],"side":[20],"effects":[21,103],"due":[22],"to":[23,50,58,122],"the":[24,59,79,84,90,112,129,135,139],"drug":[25],"administration":[26,143],"observed.":[28,94],"Sixteen":[29],"showing":[31],"at":[32],"least":[33],"25%":[34],"decrease":[35],"of":[36,63,83,131],"post":[37],"exercise":[38],"lactate":[39],"levels":[40],"selected":[42],"as":[43],"responders.":[44],"Responsiveness":[45],"was":[46],"apparently":[47],"not":[48,97,108],"related":[49],"CoQ10":[51,75,100,132],"level":[52],"serum":[54],"and":[55,107,116,119],"platelets":[56],"or":[57,61,76],"presence":[60],"absence":[62],"mtDNA":[64],"deletions.":[65],"The":[66],"responders":[67,125],"further":[69],"3":[72],"placebo":[77],"second":[80],"blind":[81],"part":[82],"trial;":[85],"no":[86],"significant":[87],"differences":[88],"between":[89],"2":[91],"groups":[92],"It":[95],"is":[96,148],"clear":[98],"why":[99],"had":[101],"therapeutic":[102],"some":[105],"others":[110],"same":[113],"clinical":[114],"presentation":[115],"biochemical":[117],"defect,":[118],"we":[120],"failed":[121],"identify":[123],"candidate":[124],"before":[126,145],"treatment.":[127],"At":[128],"dosage":[130],"used":[133],"study":[136],"(2":[137],"mg/kg/day)":[138],"therapy":[140],"requires":[141],"long":[142],"time":[144],"a":[146],"response":[147],"demonstrable.":[149]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
