{"id":"https://openalex.org/W751993575","doi":null,"title":"Express\u00e3o g\u00eanica em s\u00edndrome mielodispl\u00e1sica do subtipo AREB","display_name":"Express\u00e3o g\u00eanica em s\u00edndrome mielodispl\u00e1sica do subtipo AREB","publication_year":2010,"publication_date":"2010-10-05","ids":{"openalex":"https://openalex.org/W751993575","mag":"751993575"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:1748798","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/102729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/102729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030635442","display_name":"Carlos F. Mendiburu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carlos F. Mendiburu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030635442"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-anemia-with-excess-blasts","display_name":"refractory anemia with excess blasts","score":0.8999999761581421},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.8009999990463257},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sgpl1","display_name":"SGPL1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/numb","display_name":"Numb","score":0.972000002861023},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.9580000042915344},{"id":"https://openalex.org/keywords/msh2","display_name":"MSH2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rhog","display_name":"RhoG","score":0.9940000176429749},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/icam-3","display_name":"ICAM-3","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ykl-40","display_name":"YKL-40","score":0.9390000104904175},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.656000018119812},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35179197788238525}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:1748798","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/102729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.unesp.br:11449/102729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/102729","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:acervodigital.unesp.br:11449/102729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/102729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400256","display_name":"Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115194","host_organization_name":"Funda\u00e7\u00e3o para o Desenvolvimento da UNESP","host_organization_lineage":["https://openalex.org/I4210115194"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"outro"},{"id":"mag:751993575","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unesp.br/handle/11449/102729","pdf_url":null,"source":{"id":"https://openalex.org/S4210186100","display_name":"Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences","issn_l":"2639-6440","issn":["2639-6440","2639-6459"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1748798","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/102729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W109212544","https://openalex.org/W1480064804","https://openalex.org/W1966133006","https://openalex.org/W1966828006","https://openalex.org/W1969544207","https://openalex.org/W1971559763","https://openalex.org/W1973734969","https://openalex.org/W1977284533","https://openalex.org/W1983392832","https://openalex.org/W1984545458","https://openalex.org/W2001286107","https://openalex.org/W2001780798","https://openalex.org/W2006639171","https://openalex.org/W2010888033","https://openalex.org/W2012749999","https://openalex.org/W2041116036","https://openalex.org/W2046488041","https://openalex.org/W2052894208","https://openalex.org/W2070721758","https://openalex.org/W2072555538","https://openalex.org/W2088971752","https://openalex.org/W2108244474","https://openalex.org/W2116787167","https://openalex.org/W2120686569","https://openalex.org/W2124261225","https://openalex.org/W2124953890","https://openalex.org/W2134651401","https://openalex.org/W2136890400","https://openalex.org/W2137035181","https://openalex.org/W2143047404","https://openalex.org/W2146516445","https://openalex.org/W2153053980","https://openalex.org/W2161508400","https://openalex.org/W2164578725"],"related_works":["https://openalex.org/W3128053240","https://openalex.org/W7099007280","https://openalex.org/W2136890400","https://openalex.org/W3015784471","https://openalex.org/W2944431729","https://openalex.org/W2152125484","https://openalex.org/W3094967101","https://openalex.org/W2905939645","https://openalex.org/W2256676323","https://openalex.org/W2590613798"],"abstract_inverted_index":{"O":[0,45,138],"subtipo":[1],"Anemia":[2],"Refrataria":[3],"com":[4,63,219],"Excesso":[5],"de":[6,11,15,25,31,61,71,77,79,81,140,169,174,198,203,217,224,230,258,280],"Blastos":[7],"(AREB)":[8],"representa":[9],"cerca":[10],"30%":[12],"dos":[13,125,142,158,289],"casos":[14],"S\u00edndromes":[16],"Mielodispl\u00e1sicas":[17],"(SMD).":[18],"Os":[19,160,187,233],"pacientes":[20,62,127,218],"apresentam":[21,221],"uma":[22],"sobrevida":[23],"media":[24],"poucos":[26],"meses":[27,130,173],"e":[28,90,103,105,113,124,146,150,163,209,240,243,247,253],"risco":[29],"alto":[30],"progress\u00e3o":[32],"para":[33,117],"Leucemia":[34],"Miel\u00f3ide":[35],"Aguda.":[36],"As":[37,213],"bases":[38],"moleculares":[39],"da":[40,57,176,195,211,215],"doen\u00e7a":[41],"n\u00e3o":[42],"est\u00e3o":[43,245],"elucidadas.":[44],"objetivo":[46],"do":[47,131],"presente":[48],"trabalho":[49],"foi":[50,152],"investigar":[51],"a":[52,67,75,193,286],"express\u00e3o":[53,141,170,225,259,268,287],"g\u00eanica":[54,226],"das":[55,228],"c\u00e9lulas":[56,214],"medula":[58],"\u00f3ssea":[59],"(MO)":[60],"AREB.":[64],"Foi":[65],"gerada":[66],"primeira":[68],"biblioteca":[69,196],"SAGE":[70,197],"AREB,":[72],"ao":[73,122,154,250],"diagnostico,":[74,155],"partir":[76],"amostras":[78,120],"MO":[80,216,231],"seis":[82,129,172,261],"pacientes.":[83,159],"A":[84],"compara\u00e7\u00e3o":[85],"entre":[86],"as":[87],"bibliotecas":[88],"AREB":[89,199,220],"normal":[91],"evidenciou":[92],"genes":[93,97,144,161,204,234,290],"diferencialmente":[94],"expressos.":[95],"Cinco":[96],"hipo-expressos,":[98],"TXNIP,":[99,235,294],"SGPL1,":[100,236,293],"NUMB,":[101,292],"FOXO":[102],"MSH2,":[104,241],"outros":[106],"cinco":[107,143],"hiper-expressos,":[108,148,248],"MIF,":[109],"RHOG,":[110,244],"ICAM3,":[111],"CHI3L1":[112],"NOTCH1":[114,181,264],"foram":[115],"selecionados":[116],"valida\u00e7\u00e3o":[118],"nas":[119],"coletadas":[121],"diagnostico":[123],"mesmos":[126],"ap\u00f3s":[128,171,260,269],"diagn\u00f3stico,":[132],"por":[133],"PCR":[134],"em":[135,156,184,276],"tempo":[136],"real.":[137],"padr\u00e3o":[139,168,257],"hipo-expressos":[145],"dois":[147],"MIF":[149,242],"RHOG":[151,164,254],"confirmado,":[153],"60%":[157],"NUMB":[162,252],"mostraram":[165],"o":[166,179,201],"mesmo":[167],"evolu\u00e7l\u00e3o":[175],"doen\u00e7a,":[177],"enquanto":[178],"gene.":[180],"apresentou":[182],"hiper-express\u00e3o":[183],"duas":[185],"amostras.":[186],"dados":[188],"aqui":[189],"obtidos":[190],"mostram":[191],"que":[192,285],"cria\u00e7\u00e3o":[194],"permite":[200],"estudo":[202],"possivelemente":[205],"envolvidos":[206],"na":[207],"origem":[208],"evolu\u00e7\u00e3o":[210],"doen\u00e7a.":[212],"um":[222,277],"perfil":[223],"diferente":[227],"celulas":[229],"normal.":[232],"NUM":[237],"e,":[238],"FOXO3,":[239,291],"hipo":[246],"respectivamente,":[249],"diagn\u00f3stico.":[251],"mant\u00eam":[255],"seu":[256],"meses,":[262],"mas":[263],"parece":[265],"aumentar":[266],"sua":[267],"este":[270],"per\u00edodo.,Estes":[271],"resultados":[272],"devem":[273],"ser":[274],"confirmados":[275],"n\u00famero":[278],"maior":[279],"amostras,":[281],"no":[282],"entanto,":[283],"demonstram":[284],"alterada":[288],"MSH2...":[295]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}
