{"id":"https://openalex.org/W7519788","doi":null,"title":"Antagonists of benzodiazepines.","display_name":"Antagonists of benzodiazepines.","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W7519788","mag":"7519788","pmid":"https://pubmed.ncbi.nlm.nih.gov/6144509"},"language":"en","primary_location":{"id":"pmid:6144509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6144509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"L'Encephale","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000376319","display_name":"Willy E. Haefely","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"W Haefely","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000376319"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6675,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.57227139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"4 Suppl 2","first_page":"143B","last_page":"150B"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepine-receptor-antagonists","display_name":"benzodiazepine antagonists","score":0.9810000061988831},{"id":"https://openalex.org/keywords/benzodiazepine-receptor","display_name":"benzodiazepine receptor","score":0.9240000247955322},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ro-15-1788","display_name":"Ro 15-1788","score":0.8870000243186951},{"id":"https://openalex.org/keywords/competitive-antagonism","display_name":"competitive antagonism","score":0.5519999861717224},{"id":"https://openalex.org/keywords/inverse-agonists","display_name":"inverse agonists","score":0.8539999723434448},{"id":"https://openalex.org/keywords/gaba-antagonists","display_name":"GABA antagonists","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9929999709129333},{"id":"https://openalex.org/keywords/methylxanthines","display_name":"methylxanthines","score":0.9240000247955322},{"id":"https://openalex.org/keywords/anxiogenic-drugs","display_name":"anxiogenic drugs","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.649887204170227},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5798274874687195},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.57242751121521},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.5640736222267151},{"id":"https://openalex.org/C2778900099","wikidata":"https://www.wikidata.org/wiki/Q5166679","display_name":"Convulsant","level":3,"score":0.5536723732948303},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.5153722167015076},{"id":"https://openalex.org/C2779324764","wikidata":"https://www.wikidata.org/wiki/Q416602","display_name":"Picrotoxin","level":4,"score":0.45455682277679443},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.4413844645023346},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4409513771533966},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.43200981616973877},{"id":"https://openalex.org/C2779706987","wikidata":"https://www.wikidata.org/wiki/Q408265","display_name":"Lorazepam","level":2,"score":0.43169087171554565},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40338483452796936},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37562885880470276},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34812015295028687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1735878586769104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12008416652679443},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07219082117080688}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001570","descriptor_name":"Benzodiazepinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:6144509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6144509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"L'Encephale","raw_type":"Comparative Study"},{"id":"mag:7519788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6144509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2068973641","https://openalex.org/W2027025368","https://openalex.org/W1979077465","https://openalex.org/W2099656914","https://openalex.org/W2082760637","https://openalex.org/W2041239249","https://openalex.org/W2062733603","https://openalex.org/W2052945913","https://openalex.org/W2325806007","https://openalex.org/W175273854","https://openalex.org/W1968885904","https://openalex.org/W2071079734"],"related_works":["https://openalex.org/W2405399568","https://openalex.org/W2014066806","https://openalex.org/W1967507956","https://openalex.org/W1685633387","https://openalex.org/W2017363078","https://openalex.org/W147500199","https://openalex.org/W201946212","https://openalex.org/W2016224011","https://openalex.org/W2436833155","https://openalex.org/W1991861023"],"abstract_inverted_index":{"Benzodiazepines":[0],"(BDZ)":[1],"interact":[2,58],"with":[3,59,66],"specific":[4,112],"receptors":[5],"(R),":[6],"whose":[7,19],"activation":[8],"improves":[9],"Cl-":[10,188],"-channel":[11,189],"gating":[12],"by":[13,101,121,178,204],"the":[14,33,46,63,67,97,104,109,123,146,175,183],"GABA":[15],"receptor":[16],"(GABA-R).":[17],"Neurones,":[18],"GABAergic":[20,60],"input":[21],"has":[22],"a":[23,180],"certain":[24],"level":[25],"of":[26,35,48,69,99,117,129,152,182,193],"activity,":[27],"will":[28,52,139],"be":[29,54],"more":[30],"inhibited":[31],"in":[32,136,142,155],"presence":[34],"BDZ":[36,80,85,94,100,113,153,163,176],"(primary":[37],"target":[38,50,73],"neurones":[39,43,51,74],"for":[40],"BDZ).":[41],"Secondarily,":[42],"dependent":[44],"on":[45],"activity":[47],"primary":[49,70],"also":[53,135],"effected.":[55],"Drugs":[56],"that":[57,170],"functions":[61],"(except":[62],"BDZ-R)":[64],"or":[65,71,78],"function":[68],"secondary":[72],"may":[75],"inhibit":[76,96],"some":[77],"all":[79,126],"effects;":[81],"these":[82,194],"are":[83,202],"nonspecific":[84],"antagonists":[86,95],"(e.g.":[87,197],"GABA-antagonists,":[88],"cholinesterase":[89],"inhibitors,":[90],"naloxone,":[91],"methylxanthines).":[92],"Specific":[93],"action":[98,120],"blocking":[102],"competitively":[103],"BDZ-R.":[105],"Ro":[106,211],"15-1788":[107],"is":[108,132],"best":[110],"investigated":[111],"antagonist.":[114],"Virtually":[115],"devoid":[116],"any":[118],"pharmacological":[119],"itself,":[122],"compound":[124],"blocks":[125],"typical":[127],"effects":[128,172,192],"BDZ.":[130],"It":[131],"well":[133],"tolerated":[134],"man":[137],"and":[138,148,154],"find":[140],"application":[141],"anaesthesiology":[143],"to":[144,158,174],"shorten":[145],"sedative":[147],"muscle":[149],"relaxant":[150],"effect":[151],"emergency":[156],"services":[157],"reverse":[159],"comatose":[160],"states":[161],"after":[162],"overdosage.":[164],"Recently":[165],"drugs":[166],"have":[167],"been":[168],"found":[169],"produce":[171],"opposite":[173],"tranquilizers":[177],"inducing":[179],"conformation":[181],"BDZ-R":[184,207],"which":[185],"depresses":[186],"GABA-mediated":[187],"gating.":[190],"The":[191],"inverse":[195],"agonists":[196],"proconvulsant":[198],",":[199],"convulsant,":[200],"anxiogenic)":[201],"blocked":[203],"pure":[205],"competitive":[206],"blockers,":[208],"such":[209],"as":[210],"15-1788.":[212]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}