{"id":"https://openalex.org/W751626774","doi":null,"title":"A study of intracoronary gene transfer using stents coated with plasmid vectors","display_name":"A study of intracoronary gene transfer using stents coated with plasmid vectors","publication_year":2011,"publication_date":"2011-10-21","ids":{"openalex":"https://openalex.org/W751626774","mag":"751626774"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/59fbefa8-474a-4cc5-9fc3-da9f822b7b5b","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/59fbefa8-474a-4cc5-9fc3-da9f822b7b5b","pdf_url":"https://pure.manchester.ac.uk/ws/files/54512031/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Doctor of Medicine"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.manchester.ac.uk/ws/files/54512031/FULL_TEXT.PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080067008","display_name":"Paul D. Williams","orcid":"https://orcid.org/0000-0002-5601-1214","observed_orcids":["https://orcid.org/0000-0002-5601-1214"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul D. Williams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5601-1214","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080067008"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmid-vectors","display_name":"plasmid vectors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/fibromodulin","display_name":"fibromodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/restenosis","display_name":"restenosis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/endothelialization","display_name":"endothelialization","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.7049999833106995},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.8949999809265137},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.879692792892456},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6545040607452393},{"id":"https://openalex.org/C2778095995","wikidata":"https://www.wikidata.org/wiki/Q17147174","display_name":"Neointimal hyperplasia","level":4,"score":0.5833533406257629},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.562860369682312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5286120772361755},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5145635008811951},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.48140954971313477},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4631234109401703},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4450221359729767},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41008061170578003},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3844137489795685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3553345799446106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28664636611938477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28381747007369995},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.27728813886642456},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2708622217178345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23297855257987976},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07117971777915955},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/59fbefa8-474a-4cc5-9fc3-da9f822b7b5b","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/59fbefa8-474a-4cc5-9fc3-da9f822b7b5b","pdf_url":"https://pure.manchester.ac.uk/ws/files/54512031/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Doctor of Medicine"},{"id":"mag:751626774","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548698","pdf_url":null,"source":{"id":"https://openalex.org/S4306532716","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2011.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2011.","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/59fbefa8-474a-4cc5-9fc3-da9f822b7b5b","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/59fbefa8-474a-4cc5-9fc3-da9f822b7b5b","pdf_url":"https://pure.manchester.ac.uk/ws/files/54512031/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Doctor of Medicine"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W751626774.pdf","grobid_xml":"https://content.openalex.org/works/W751626774.grobid-xml"},"referenced_works_count":236,"referenced_works":["https://openalex.org/W145716214","https://openalex.org/W158281719","https://openalex.org/W158512522","https://openalex.org/W165015491","https://openalex.org/W197569723","https://openalex.org/W345774991","https://openalex.org/W1409723433","https://openalex.org/W1433020779","https://openalex.org/W1437166545","https://openalex.org/W1482943240","https://openalex.org/W1519059617","https://openalex.org/W1527614413","https://openalex.org/W1544527238","https://openalex.org/W1566538275","https://openalex.org/W1581394639","https://openalex.org/W1599588446","https://openalex.org/W1652158629","https://openalex.org/W1748510480","https://openalex.org/W1769569140","https://openalex.org/W1893232111","https://openalex.org/W1893746779","https://openalex.org/W1934789023","https://openalex.org/W1944346348","https://openalex.org/W1964129959","https://openalex.org/W1965023503","https://openalex.org/W1966700556","https://openalex.org/W1967236086","https://openalex.org/W1969272947","https://openalex.org/W1971318940","https://openalex.org/W1971428935","https://openalex.org/W1972202719","https://openalex.org/W1972403135","https://openalex.org/W1975844162","https://openalex.org/W1975897223","https://openalex.org/W1976329054","https://openalex.org/W1976621728","https://openalex.org/W1977108718","https://openalex.org/W1977656956","https://openalex.org/W1977712028","https://openalex.org/W1978762517","https://openalex.org/W1979781324","https://openalex.org/W1984846299","https://openalex.org/W1985317029","https://openalex.org/W1989072328","https://openalex.org/W1990064683","https://openalex.org/W1990101447","https://openalex.org/W1992874926","https://openalex.org/W1993450395","https://openalex.org/W1994495694","https://openalex.org/W1994748799","https://openalex.org/W1997587490","https://openalex.org/W1997810397","https://openalex.org/W1998539941","https://openalex.org/W1998792752","https://openalex.org/W1999124647","https://openalex.org/W2001089762","https://openalex.org/W2002509647","https://openalex.org/W2002867354","https://openalex.org/W2003811379","https://openalex.org/W2004983645","https://openalex.org/W2005566723","https://openalex.org/W2006846934","https://openalex.org/W2007261697","https://openalex.org/W2007276010","https://openalex.org/W2007737411","https://openalex.org/W2008537184","https://openalex.org/W2008944073","https://openalex.org/W2009407308","https://openalex.org/W2010203748","https://openalex.org/W2010388612","https://openalex.org/W2013173848","https://openalex.org/W2013641657","https://openalex.org/W2014326933","https://openalex.org/W2014932890","https://openalex.org/W2015221134","https://openalex.org/W2015761641","https://openalex.org/W2017451104","https://openalex.org/W2020553825","https://openalex.org/W2021735119","https://openalex.org/W2022713347","https://openalex.org/W2025616153","https://openalex.org/W2027840972","https://openalex.org/W2028286302","https://openalex.org/W2028441859","https://openalex.org/W2028821876","https://openalex.org/W2031365893","https://openalex.org/W2031856561","https://openalex.org/W2033105319","https://openalex.org/W2034947637","https://openalex.org/W2038585115","https://openalex.org/W2039010543","https://openalex.org/W2041526969","https://openalex.org/W2042249648","https://openalex.org/W2043852940","https://openalex.org/W2044966389","https://openalex.org/W2045026552","https://openalex.org/W2047426600","https://openalex.org/W2048166086","https://openalex.org/W2049120615","https://openalex.org/W2050875708","https://openalex.org/W2051786926","https://openalex.org/W2052612816","https://openalex.org/W2055821904","https://openalex.org/W2056842529","https://openalex.org/W2057112435","https://openalex.org/W2058344926","https://openalex.org/W2058834825","https://openalex.org/W2060497978","https://openalex.org/W2060923941","https://openalex.org/W2061555550","https://openalex.org/W2062522737","https://openalex.org/W2063242845","https://openalex.org/W2065179820","https://openalex.org/W2065334138","https://openalex.org/W2066334316","https://openalex.org/W2066387850","https://openalex.org/W2067150844","https://openalex.org/W2068350301","https://openalex.org/W2068370931","https://openalex.org/W2070086097","https://openalex.org/W2070725184","https://openalex.org/W2071138105","https://openalex.org/W2072139568","https://openalex.org/W2072578546","https://openalex.org/W2072998283","https://openalex.org/W2073141218","https://openalex.org/W2074497710","https://openalex.org/W2074919956","https://openalex.org/W2076845203","https://openalex.org/W2078396087","https://openalex.org/W2078608058","https://openalex.org/W2079818105","https://openalex.org/W2080963472","https://openalex.org/W2083630382","https://openalex.org/W2087027548","https://openalex.org/W2087282233","https://openalex.org/W2087641863","https://openalex.org/W2087782760","https://openalex.org/W2087920840","https://openalex.org/W2090146642","https://openalex.org/W2090987250","https://openalex.org/W2092483727","https://openalex.org/W2092998815","https://openalex.org/W2096801164","https://openalex.org/W2099704453","https://openalex.org/W2100298490","https://openalex.org/W2100637102","https://openalex.org/W2102067073","https://openalex.org/W2102162317","https://openalex.org/W2102374129","https://openalex.org/W2103450378","https://openalex.org/W2104979755","https://openalex.org/W2105332661","https://openalex.org/W2105884473","https://openalex.org/W2106232223","https://openalex.org/W2106820552","https://openalex.org/W2107131858","https://openalex.org/W2108084079","https://openalex.org/W2108106334","https://openalex.org/W2108866232","https://openalex.org/W2109959116","https://openalex.org/W2110561647","https://openalex.org/W2111630252","https://openalex.org/W2112225171","https://openalex.org/W2112494872","https://openalex.org/W2114171855","https://openalex.org/W2114642696","https://openalex.org/W2115306398","https://openalex.org/W2116323280","https://openalex.org/W2116362164","https://openalex.org/W2118606605","https://openalex.org/W2120754408","https://openalex.org/W2120882298","https://openalex.org/W2121822802","https://openalex.org/W2122634753","https://openalex.org/W2123550509","https://openalex.org/W2124242147","https://openalex.org/W2124282712","https://openalex.org/W2125150769","https://openalex.org/W2127507533","https://openalex.org/W2128163162","https://openalex.org/W2128421976","https://openalex.org/W2128593286","https://openalex.org/W2129486415","https://openalex.org/W2129811129","https://openalex.org/W2130123200","https://openalex.org/W2130250466","https://openalex.org/W2131370832","https://openalex.org/W2132943628","https://openalex.org/W2133070487","https://openalex.org/W2133090725","https://openalex.org/W2133131432","https://openalex.org/W2134734822","https://openalex.org/W2134775670","https://openalex.org/W2138009608","https://openalex.org/W2140229204","https://openalex.org/W2142334980","https://openalex.org/W2142799375","https://openalex.org/W2143647993","https://openalex.org/W2143962152","https://openalex.org/W2144533837","https://openalex.org/W2146743728","https://openalex.org/W2147395274","https://openalex.org/W2147643233","https://openalex.org/W2148389596","https://openalex.org/W2148421640","https://openalex.org/W2149753712","https://openalex.org/W2149831361","https://openalex.org/W2149933426","https://openalex.org/W2150755435","https://openalex.org/W2151225187","https://openalex.org/W2151857625","https://openalex.org/W2153114024","https://openalex.org/W2154186340","https://openalex.org/W2154286360","https://openalex.org/W2154355618","https://openalex.org/W2156613502","https://openalex.org/W2156854226","https://openalex.org/W2159629829","https://openalex.org/W2160162934","https://openalex.org/W2160613916","https://openalex.org/W2160631086","https://openalex.org/W2163076834","https://openalex.org/W2164466909","https://openalex.org/W2165441306","https://openalex.org/W2165568231","https://openalex.org/W2165806143","https://openalex.org/W2165872135","https://openalex.org/W2167845957","https://openalex.org/W2169000150","https://openalex.org/W2169804478","https://openalex.org/W2219149197","https://openalex.org/W2304337690","https://openalex.org/W2314714940","https://openalex.org/W2333049114","https://openalex.org/W2398240417"],"related_works":["https://openalex.org/W2798845165","https://openalex.org/W2092483727","https://openalex.org/W4320516902","https://openalex.org/W2114317101","https://openalex.org/W1490097577","https://openalex.org/W2038281552","https://openalex.org/W2338198326","https://openalex.org/W2056842529","https://openalex.org/W1482943240","https://openalex.org/W2125150769"],"abstract_inverted_index":{"Percutaneous":[0],"coronary":[1,15,156,175],"intervention":[2],"with":[3,14,31,60,136,158,231,234,242,245],"stent":[4,41],"deployment":[5],"is":[6,100,106],"the":[7,23,49,57,61,162,190,205,228,239,246,273],"dominant":[8],"form":[9],"of":[10,25,45,63,110,164,192,207,252,260,272,294,309],"revascularisation":[11],"for":[12,321],"patients":[13],"artery":[16,176],"disease.":[17],"Although":[18],"drug-eluting":[19],"stents":[20,47,157,167,232,243],"have":[21,116],"reduced":[22],"incidence":[24],"instent":[26],"restenosis,":[27],"they":[28],"are":[29,316,327],"associated":[30],"late":[32,40,222],"problems":[33],"related":[34],"to":[35,51,56,120,142,203,255,268,275,303],"delayed":[36],"vascular":[37,58,147],"healing":[38],"including":[39],"thrombosis.":[42],"The":[43],"use":[44],"gene-eluting":[46,166],"offers":[48],"potential":[50,307],"deliver":[52],"localised":[53],"gene":[54,211,248,288,325],"therapy":[55,326],"wall":[59],"aim":[62],"both":[64],"reducing":[65],"restenosis":[66,122],"and":[67,84,90,105,161,198,238,318],"promoting":[68],"endothelialisation.Two":[69],"candidate":[70],"genes":[71,115,133],"were":[72,134,153,168,200],"investigated.":[73],"Connective":[74],"tissue":[75],"growth":[76,87],"factor":[77],"(CTGF)":[78],"promotes":[79],"smooth":[80,148],"muscle":[81,149],"cell":[82],"apoptosis":[83],"stimulates":[85],"endothelial":[86],"in":[88,95,102,123,146,170,172,220,285,286,313],"vitro,":[89],"has":[91,183],"an":[92,124,137,171],"integral":[93],"role":[94],"wound":[96,112],"healing.":[97,113],"Fibromodulin":[98],"(FMOD)":[99],"involved":[101],"collagen":[103],"metabolism":[104],"a":[107,159,258,269,277,292],"key":[108],"mediator":[109],"scarless":[111],"Both":[114],"previously":[117],"been":[118],"shown":[119],"suppress":[121],"ex":[125],"vivo":[126,173,287],"vein":[127],"graft":[128],"model.Plasmids":[129],"containing":[130],"these":[131,165],"two":[132],"constructed":[135],"expression":[138,145,194,264,289,312],"cassette":[139],"specially":[140],"designed":[141],"maximise":[143],"transgene":[144,193,263,305,311],"cells.":[150],"These":[151],"plasmids":[152],"coated":[154,233,244],"onto":[155],"polymer":[160],"effects":[163],"investigated":[169],"pig":[174],"model.":[177],"Previous":[178],"work":[179],"by":[180],"our":[181],"group":[182,240],"suggested":[184],"that":[185],"systemic":[186],"?-blockade":[187],"can":[188],"affect":[189],"degree":[191],"from":[195],"viral":[196],"vectors,":[197],"experiments":[199],"also":[201],"performed":[202],"investigate":[204],"effect":[206],"?-blockers":[208],"on":[209,323],"plasmid-mediated":[210,324],"expression.At":[212],"28":[213],"days":[214],"there":[215],"was":[216,282,300],"no":[217,283],"significant":[218],"difference":[219,284],"angiographic":[221],"loss":[223],"or":[224,236],"neointimal":[225],"hyperplasia":[226],"between":[227],"groups":[229],"treated":[230,241],"FMOD":[235],"CTGF":[237],"marker":[247],"lacZ.":[249],"This":[250],"lack":[251],"efficacy":[253],"appeared":[254],"be":[256],"as":[257,291],"result":[259,293,299],"extremely":[261],"poor":[262,310],"rather":[265],"than":[266],"due":[267,302],"genuine":[270],"failure":[271],"transgenes":[274],"elicit":[276],"relevant":[278],"biological":[279],"effect.":[280],"There":[281],"demonstrated":[290],"?-blockade,":[295],"but":[296],"again":[297],"this":[298,314],"probably":[301],"limited":[304],"expression.The":[306],"causes":[308],"study":[315],"reviewed":[317],"future":[319],"directions":[320],"research":[322],"considered.":[328]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
